Product image of Melatonin Orifarm (Melatonin) supplied by GNH India

Melatonin Orifarm

Active Ingredient:
Melatonin
Origin:
EU

Melatonin Orifarm (Melatonin)

Melatonin, the active ingredient in Melatonin Orifarm, is a melatonin receptor agonist presented as an oral tablet for oral use. It treats insomnia and sleep‑wake rhythm disorders in adults.
GNH India supplies Melatonin Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Melatonin Orifarm acts on the melatonin MT1 and MT2 receptors to regulate circadian rhythm and support sleep.

  • Insomnia: helps reduce sleep onset latency and improve sleep maintenance in adults.
  • Sleep‑wake rhythm disorders: assists in normalising disrupted sleep‑wake cycles such as delayed sleep phase syndrome.
  • Jet lag: aids adjustment of the internal clock after rapid east‑west travel, promoting faster sleep onset at the new destination.

How It Works

  • Melatonin Orifarm binds to melatonin MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking endogenous melatonin. This activation synchronises the circadian clock, signalling the body that it is night, thereby facilitating the onset of sleep and stabilising sleep‑wake patterns.

Side Effects

Melatonin Orifarm may cause adverse reactions, most of which are mild and transient.

Common Side Effects

  • Drowsiness or daytime sleepiness
  • Headache
  • Dizziness
  • Nausea or mild gastrointestinal discomfort
  • Vivid dreams or nightmares
  • Mild abdominal cramps

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching, or angioedema
  • Severe dizziness or vertigo
  • Mood changes including depression or hallucinations
  • Abnormal heart rhythm or palpitations
  • Severe gastrointestinal upset or vomiting
  • Rare cases of seizures in predisposed individuals

Precautions & Warnings

When considering Melatonin Orifarm, several safety measures should be observed.

  • Assess underlying sleep disorder: confirm diagnosis before use.
  • Avoid concurrent alcohol consumption: may increase sedation.
  • Monitor patients with depression: melatonin can affect mood.
  • Use caution in hepatic impairment: metabolism may be altered.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Melatonin Orifarm can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent use with CNS depressants (e.g., benzodiazepines, barbiturates): increased sedation risk.
  • Interaction with anticoagulants (e.g., warfarin): potential for enhanced bleeding.
  • Co‑administration with immunosuppressants (e.g., cyclosporine): possible alteration of drug levels.

Moderate Interactions (Monitor Closely)

  • Combination with caffeine or other stimulants: may reduce melatonin efficacy.
  • Use with oral contraceptives: possible reduction in contraceptive effectiveness.
  • Interaction with antihypertensives: may cause additive blood‑pressure lowering.

Frequently Asked Questions

Melatonin Orifarm is an over‑the‑counter oral product that contains melatonin, a hormone that helps regulate the sleep‑wake cycle. It is commonly used to manage occasional insomnia, adjust disrupted circadian rhythms, and alleviate jet‑lag symptoms in adults.

Melatonin works by binding to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus, the central clock that controls circadian rhythms. This receptor activation signals that it is night, promoting sleep onset and helping to synchronise the body’s internal timing.

The appropriate dose of Melatonin Orifarm is determined by a qualified healthcare professional based on the individual’s age, condition, and response. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety data for melatonin use in pregnancy and lactation are limited, and the product’s pregnancy category is listed as unknown. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their physician before using Melatonin Orifarm.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Melatonin Orifarm differs from prescription hypnotics such as zolpidem or benzodiazepines because it works by mimicking a natural hormone rather than depressing the central nervous system. It generally has a milder side‑effect profile, but its efficacy may be limited to mild‑to‑moderate sleep disturbances.

Store Melatonin Orifarm at room temperature, below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain potency throughout its shelf life.

Melatonin Orifarm is taken orally, usually with a glass of water. For optimal effect, it is commonly recommended to ingest the tablet 30‑60 minutes before the intended bedtime, unless the prescribing clinician advises otherwise.

Serious but rare risks include allergic reactions such as rash, angioedema, or anaphylaxis, as well as severe dizziness, mood changes like depression or hallucinations, and abnormal heart rhythms. Any of these symptoms should prompt immediate medical attention.

Individuals with known hypersensitivity to melatonin, those taking certain CNS depressants without medical supervision, patients with uncontrolled depression, and persons with severe hepatic impairment should avoid using Melatonin Orifarm unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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