Product image of Melatonin Pharma Nord (Melatonin) supplied by GNH India

Melatonin Pharma Nord

Active Ingredient:
Melatonin
Origin:
EU

Melatonin Pharma Nord (Melatonin)

Melatonin, the active ingredient in Melatonin Pharma Nord, is a melatonin receptor agonist presented as an oral tablet for oral use. It modulates circadian rhythm by activating MT1 and MT2 receptors, thereby supporting the initiation and maintenance of sleep in adults with insomnia, jet lag, or other sleep‑wake rhythm disturbances.

GNH India supplies Melatonin Pharma Nord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent product quality, regulatory adherence and reliable logistics for global healthcare providers.

Manufacturer / TM Owner

Pharma Nord Aps (Vojens)

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Indications & Clinical Uses

  • Melatonin acts on melatonin receptors to help normalize the sleep‑wake cycle.
  • Insomnia: helps shorten the time needed to fall asleep, increase total sleep time and improve sleep quality in adults experiencing difficulty initiating or maintaining sleep.
  • Jet lag: facilitates faster realignment of the internal clock after rapid travel across time zones, reducing daytime sleepiness and nighttime awakenings.
  • Sleep‑wake rhythm disorders: supports the regulation of abnormal circadian patterns, aiding individuals with shift‑work disorder, delayed sleep phase syndrome or non‑24‑hour sleep‑wake rhythm disorder to achieve more regular sleep timing.

How It Works

  • Melatonin binds to and activates the MT1 and MT2 G‑protein‑coupled receptors located in the suprachiasmatic nucleus of the hypothalamus. This activation mimics the endogenous hormone signal that rises in the evening, leading to inhibition of neuronal firing that promotes wakefulness and facilitating the onset of sleep, thereby synchronizing the circadian rhythm with the external light‑dark cycle and contributing to downstream changes in melatonin‑responsive gene expression.

Side Effects

Melatonin is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

  • Drowsiness: feeling unusually sleepy during daytime activities.
  • Headache: mild to moderate pain in the head.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: mild stomach upset or queasiness.
  • Fatigue: general lack of energy or feeling tired.
  • Abdominal cramps: mild stomach discomfort or cramping.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Mood changes: depression, agitation, vivid dreams or anxiety.

Precautions & Warnings

When considering melatonin, certain precautions and warnings should be observed.

  • Age restriction: not recommended for children unless advised by a healthcare professional.
  • Pregnancy and lactation: use only if clearly needed and prescribed by a physician.
  • Concomitant CNS depressants: avoid combining with alcohol or sedatives without medical guidance.
  • Underlying medical conditions: assess for uncontrolled hypertension, depression or seizure disorders before use.
  • Driving and machinery: avoid operating heavy machinery until individual response to melatonin is known.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Melatonin may interact with other substances, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants/antiplatelet agents: may increase risk of bleeding.
  • Immunosuppressants (e.g., cyclosporine): melatonin can alter drug metabolism.

Moderate Interactions (Monitor Closely)

  • CNS depressants (benzodiazepines, barbiturates): additive sedative effect.
  • Oral contraceptives: may increase melatonin plasma levels.
  • Antidepressants (SSRIs, MAO inhibitors): potential for enhanced serotonergic activity.
  • Caffeine: may counteract melatonin’s sleep‑promoting effect.

Frequently Asked Questions

Melatonin Pharma Nord is an over‑the‑counter oral product that contains melatonin, a hormone‑mimetic used to help regulate the sleep‑wake cycle. It is indicated for short‑term management of insomnia, for alleviating jet‑lag symptoms after rapid travel across time zones, and for supporting normal circadian rhythm in adults with sleep‑wake rhythm disorders such as shift‑work disorder or delayed sleep phase syndrome.

Melatonin works by binding to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. Activation of these receptors reproduces the natural evening rise of melatonin, signaling the body that it is time to prepare for sleep. This reduces neuronal activity that promotes wakefulness and helps synchronize the internal clock with the external light‑dark cycle.

The appropriate dose of melatonin is individualized by a prescriber based on the specific indication, patient age, and clinical response. Healthcare professionals typically start with the lowest effective dose and may adjust it as needed, but exact dosing regimens should always be confirmed with the treating clinician.

Safety data for melatonin in pregnancy and lactation are limited. It should only be used during pregnancy or while breastfeeding if the potential benefit outweighs any possible risk and if it is prescribed by a qualified healthcare provider. Women who are pregnant or nursing should discuss use with their physician.

To place an order, visit the product page on gnhindia.com, enter the required quantity and submit the enquiry form. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify institutional credentials, then respond with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Melatonin differs from traditional sedative hypnotics such as benzodiazepines or antihistamines because it works by resetting the circadian clock rather than directly depressing central nervous system activity. This generally results in fewer next‑day residual effects and a lower risk of dependence, making it a preferred option for short‑term sleep timing issues, whereas classic hypnotics are often reserved for more severe insomnia.

The product should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture and direct sunlight, and ensure the packaging is tightly closed after each use to maintain stability.

Melatonin Pharma Nord is taken orally, usually with a glass of water. For most indications it is recommended to ingest the tablet about 30‑60 minutes before the desired bedtime, allowing the active ingredient to reach peak plasma concentrations as the body prepares for sleep.

Serious but rare risks include allergic reactions such as rash, itching, swelling or difficulty breathing, and mood‑related changes like depression, agitation, vivid dreams or anxiety. If any of these symptoms occur, the product should be discontinued immediately and medical attention sought.

Melatonin is not recommended for children unless specifically prescribed, for individuals with uncontrolled hypertension, severe depression, seizure disorders, or for patients taking medications that may cause dangerous interactions without proper monitoring. Pregnant or breastfeeding women should only use it under direct medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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