Product image of Melatonin Zentiva (Melatonin) supplied by GNH India

Melatonin Zentiva

Active Ingredient:
Melatonin
Origin:
EU

Melatonin Zentiva (Melatonin)

Melatonin, the active ingredient in Melatonin Zentiva, is a melatonin receptor agonist presented as a (strength)/(form) for oral use. It treats insomnia, jet lag and circadian rhythm sleep‑wake disorders in adults.

GNH India supplies Melatonin Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Melatonin Zentiva is a melatonin receptor agonist used to manage sleep‑related conditions.
  • Insomnia: helps initiate sleep and improve sleep continuity.
  • Jet lag: reduces the time needed to adjust to new time zones.
  • Circadian rhythm sleep‑wake disorder: stabilises the sleep‑wake cycle in shift‑work or delayed sleep phase syndrome.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking the endogenous hormone. Activation of these G‑protein‑coupled receptors modulates the circadian clock, lowers core body temperature and promotes the onset of sleep, thereby helping to synchronise the sleep‑wake rhythm.

Side Effects

Melatonin Zentiva may cause adverse reactions, most of which are mild and transient.

Common Side Effects

  • Drowsiness or daytime sleepiness
  • Headache
  • Dizziness
  • Nausea or abdominal discomfort

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching, swelling or difficulty breathing
  • Mood changes including depression, irritability or agitation
  • Rare cardiac effects such as abnormal heart rhythm
  • Hallucinations or vivid dreams

Precautions & Warnings

  • Before using Melatonin Zentiva, consider the following safety points.
  • Pregnancy: safety not established; consult a healthcare professional.
  • Breastfeeding: unknown safety; weigh potential benefits against risks.
  • Elderly: start with the lowest effective dose and monitor response.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Medical conditions: use cautiously in hepatic impairment.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Melatonin can interact with several medicines; review the following categories.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): may reduce melatonin efficacy.
  • CYP1A2 inhibitors (e.g., fluvoxamine): may raise melatonin plasma levels.

Moderate Interactions (Monitor Closely)

  • CNS depressants (benzodiazepines, alcohol): may enhance sedation.
  • Antidiabetic agents: possible impact on glucose control.
  • Vaccines: melatonin may modulate immune response.

Frequently Asked Questions

Melatonin Zentiva is indicated for the short‑term management of insomnia, for alleviating symptoms of jet lag, and for treating circadian rhythm sleep‑wake disorders such as delayed sleep phase syndrome or shift‑work disorder.

Melatonin mimics the natural hormone released by the pineal gland at night. It binds to MT1 and MT2 receptors in the brain’s master clock, helping to reset the circadian rhythm, lower core body temperature and promote the onset of sleep.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, condition and response. Dosage may vary from low‑dose regimens for jet lag to higher doses for chronic insomnia, and should follow the prescriber’s instructions.

Safety data for melatonin in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an enquiry, visit the product page on gnhindia.com, enter the required quantity and submit the request. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike antihistamine‑based sleep aids, melatonin works by regulating the body’s internal clock rather than causing broad sedation. It is generally better tolerated, has fewer anticholinergic effects, and is preferred for circadian‑related sleep disturbances, though efficacy can vary between individuals.

Store the product at ambient temperature below 25 °C, in the original packaging, protected from moisture and direct light. Do not refrigerate or freeze unless the label specifically advises otherwise.

Melatonin Zentiva is taken orally, usually with a glass of water. It is commonly taken 30‑60 minutes before the desired bedtime, but patients should follow the timing recommended by their prescriber.

Serious adverse reactions, although rare, include severe allergic responses (rash, swelling, breathing difficulty), marked mood changes such as depression or agitation, and rare cardiac events like abnormal heart rhythm. Any of these symptoms require immediate medical attention.

Individuals with known hypersensitivity to melatonin or any excipients, patients taking certain MAO‑inhibitors, and those with uncontrolled severe hepatic disease should avoid the product. A healthcare professional should evaluate suitability for all other users.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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