Product image of Melatonina Alter (Melatonin) supplied by GNH India

Melatonina Alter

Active Ingredient:
Melatonin
Origin:
EU

Melatonina Alter (Melatonin)

Melatonin, the active ingredient in Melatonina Alter, is a melatonin receptor agonist presented as an oral formulation for oral use. It treats insomnia, jet lag and sleep‑wake rhythm disorders in adults and children as appropriate.

GNH India supplies Melatonina Alter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alter S.A.

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Indications & Clinical Uses

Melatonin acts on the melatonin MT1 and MT2 receptors to regulate circadian rhythm and support sleep.

  • Insomnia: helps initiate and maintain sleep, reducing sleep latency.
  • Jet lag: assists in adjusting the internal clock after rapid time‑zone travel.
  • Sleep‑wake rhythm disorders: stabilises disrupted sleep patterns in shift‑work or delayed‑sleep‑phase conditions.

How It Works

  • Melatonin binds as an agonist to melatonin MT1 and MT2 receptors located in the suprachiasmatic nucleus of the hypothalamus. Activation of these G‑protein‑coupled receptors modulates the circadian signalling cascade, promoting the physiological transition toward sleep onset and supporting the maintenance of a regular sleep‑wake cycle.

Side Effects

Melatonin is generally well tolerated, but some users experience adverse reactions.

Common Side Effects

  • Drowsiness: feeling unusually sleepy during the day.
  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness.
  • Nausea: mild stomach upset.
  • Vivid dreams: unusually intense or memorable dreams.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Mood changes: depression or increased anxiety.
  • Hormonal effects: menstrual irregularities in women.
  • Severe hypotension: marked drop in blood pressure.
  • Cardiac arrhythmia: irregular heart rhythm in susceptible individuals.

Precautions & Warnings

When considering melatonin therapy, certain safety measures are recommended.

  • Pregnancy: consult a healthcare professional before use; safety data are limited.
  • Breastfeeding: discuss potential exposure with a physician.
  • Pediatric use: dosing and duration should be determined by a pediatric specialist.
  • Drug interactions: review concomitant medications for possible interactions.
  • Underlying conditions: assess for depression, epilepsy, or autoimmune disorders before initiating therapy.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Melatonin may influence the activity of several other medicines.

Major Interactions (Avoid)

  • Anticoagulants: may increase bleeding risk.
  • Immunosuppressants: could reduce efficacy of immune‑modulating therapy.

Moderate Interactions (Monitor Closely)

  • Sedatives or CNS depressants: may enhance drowsiness.
  • Oral contraceptives: potential reduction in hormonal effectiveness.
  • Antidiabetic agents: possible alteration of blood glucose control.
  • Antidepressants (SSRIs, MAOIs): may affect serotonin pathways.
  • Antihypertensives: could cause additive blood‑pressure lowering effects.

Frequently Asked Questions

Melatonina Alter contains melatonin, which is used to help manage difficulty falling asleep, reduce the effects of jet lag after rapid travel across time zones, and support regular sleep patterns in individuals with sleep‑wake rhythm disorders.

Melatonin works by binding to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus, the central regulator of circadian rhythms. This activation signals the body that it is nighttime, facilitating the transition to sleep and helping to synchronize the internal clock with external light‑dark cycles.

The appropriate dose of Melatonina Alter is determined by the prescribing clinician based on the patient’s age, condition being treated, and individual response. Dosage may vary widely, and patients should follow the specific instructions provided by their healthcare professional.

Safety data for melatonin use during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their obstetrician or qualified healthcare provider before starting Melatonina Alter.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike many prescription hypnotics that act on GABA receptors, melatonin works by mimicking the body’s natural hormone that regulates circadian rhythms. This mechanism generally results in fewer next‑day sedation effects, but efficacy may be lower for severe insomnia compared with stronger sedative agents.

Melatonina Alter should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Melatonina Alter is taken orally, usually as a tablet or capsule, with water. It is commonly taken 30‑60 minutes before the intended bedtime, but exact timing should follow the prescriber’s guidance.

Serious risks, though rare, include severe allergic reactions such as rash, swelling, or breathing difficulty, and significant hormonal effects that may disrupt menstrual cycles or exacerbate mood disorders. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with known hypersensitivity to melatonin, those taking certain anticoagulants or immunosuppressants without medical supervision, and patients with uncontrolled depression, epilepsy, or severe autoimmune disease should avoid using Melatonina Alter unless advised otherwise by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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