Product image of Melatonina Bluefish (Melatonin) supplied by GNH India

Melatonina Bluefish

Active Ingredient:
Melatonin
Origin:
EU

Melatonina Bluefish (Melatonin)

Melatonin, the active ingredient in Melatonina Bluefish, is a melatonin receptor agonist presented as an oral formulation for oral use. It is used to help regulate the sleep‑wake cycle and to promote the onset of sleep in individuals experiencing insomnia or circadian rhythm disturbances. By binding to MT1 and MT2 receptors in the suprachiasmatic nucleus, it supports the natural circadian rhythm, facilitating sleep initiation and maintenance in adults and older children.

GNH India supplies Melatonina Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

Melatonin is used to address disorders of the sleep‑wake cycle.

  • Insomnia: facilitates sleep onset and improves sleep continuity.
  • Sleep‑wake rhythm disorders: helps align the internal clock to a regular pattern.
  • Shift work disorder: reduces excessive sleepiness and improves alertness during scheduled work periods.

How It Works

  • Melatonin acts as an agonist at the MT1 and MT2 melatonin receptors located in the suprachiasmatic nucleus of the hypothalamus. Activation of these G‑protein‑coupled receptors modulates intracellular signaling pathways that synchronize the endogenous circadian rhythm to the external light‑dark cycle, thereby promoting sleep initiation and regulating the timing of physiological processes related to the sleep‑wake cycle.

Side Effects

Melatonin is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate pain often reported after ingestion.
  • Dizziness: transient sensation of light‑headedness.
  • Daytime sleepiness: residual drowsiness after nighttime dosing.
  • Nausea: occasional gastrointestinal discomfort.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, or angioedema requiring medical attention.
  • Mood changes: emergence or worsening of depression or anxiety.
  • Seizure: rare occurrence, particularly in individuals with a pre‑existing seizure disorder.

Precautions & Warnings

When using melatonin, consider the following precautions.

  • Pregnancy: safety not established; consult a healthcare professional before use.
  • Breastfeeding: unknown effects on the infant; weigh potential benefits against risks.
  • Age: use with caution in children and adolescents; dosing should be individualized.
  • Concomitant medications: review potential interactions with sedatives, anticoagulants, and hormonal therapies.
  • Medical conditions: exercise caution in patients with depression, seizure disorders, or autoimmune diseases.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture and light.

Avoid Interactions

Melatonin may interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Warfarin: melatonin may increase anticoagulant effect and alter INR.
  • Sedative CNS depressants (e.g., benzodiazepines, barbiturates): combined use can enhance drowsiness and impair coordination.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, MAOIs): may affect melatonin metabolism and alter therapeutic response.
  • CYP1A2 inhibitors (cimetidine, fluvoxamine): can raise melatonin plasma concentrations.
  • Oral contraceptives: may modify melatonin clearance, potentially requiring dose adjustment.

Frequently Asked Questions

Melatonina Bluefish contains melatonin, which is used to help regulate the sleep‑wake cycle. It is indicated for the short‑term management of insomnia and for correcting sleep‑wake rhythm disorders such as shift‑work disorder or delayed sleep phase syndrome.

Melatonin binds to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. This receptor activation signals the body that it is nighttime, helping to synchronize the internal circadian clock and facilitating the transition to sleep.

The appropriate dose of melatonin is determined by the prescribing clinician based on the individual’s age, condition, and response. Dosage may vary widely, and patients should follow the specific instructions provided by their healthcare professional.

Safety data for melatonin in pregnancy and lactation are limited. Healthcare providers generally advise caution and recommend that pregnant or breastfeeding individuals discuss potential risks and benefits with their physician before using melatonin.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike traditional hypnotics such as benzodiazepines, melatonin works by mimicking a natural hormone that regulates circadian rhythms rather than directly depressing the central nervous system. This mechanism often results in fewer next‑day residual effects, but efficacy may be limited to specific sleep‑related disorders.

Store the product at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct light. Keep the container tightly closed and out of reach of children.

Melatonin is taken orally, usually as a tablet or capsule, and is typically administered shortly before the intended bedtime. Patients should swallow the product whole with water and avoid crushing or chewing unless directed otherwise by a healthcare professional.

Serious adverse reactions, although rare, include allergic responses such as rash or angioedema, significant mood changes like worsening depression, and the potential for seizures in susceptible individuals. Any of these symptoms should prompt immediate medical evaluation.

Melatonin should be avoided in individuals with known hypersensitivity to the product, those taking certain anticoagulants without medical supervision, patients with uncontrolled depression or seizure disorders, and children unless prescribed by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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