Product image of Melatonina Noxarem (Melatonin) supplied by GNH India

Melatonina Noxarem

Active Ingredient:
Melatonin
Origin:
EU

Melatonina Noxarem (Melatonin)

Melatonin, the active ingredient in Melatonina Noxarem, is a melatonin receptor agonist presented as an oral formulation for oral use. It helps regulate the circadian rhythm and is used to support sleep onset in adults experiencing insomnia, jet lag, or other sleep disturbances.

GNH India supplies Melatonina Noxarem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across global markets and providing reliable logistics for timely delivery.

Manufacturer / TM Owner

Vemedia Manufacturing B. V.

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Indications & Clinical Uses

Melatonina Noxarem (melatonin) acts on the melatonin receptor pathway to address sleep‑related conditions.

  • Insomnia: reduces sleep latency and improves overall sleep quality.
  • Jet lag: assists in realigning the circadian rhythm after rapid time‑zone travel.
  • Shift work disorder: supports sleep initiation for individuals with irregular work schedules.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking the endogenous hormone released in darkness. Activation of these G‑protein‑coupled receptors reduces neuronal firing, lowers core body temperature, and signals the brain that night has begun, thereby facilitating the initiation and maintenance of sleep.

Side Effects

Melatonin is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

  • Drowsiness or daytime sleepiness
  • Headache
  • Dizziness
  • Nausea or mild gastrointestinal discomfort
  • Vivid dreams or nightmares
  • Mild fatigue

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching, or swelling
  • Severe daytime sleepiness affecting alertness
  • Mood changes including depression or anxiety
  • Hallucinations or confusion (rare)
  • Respiratory depression in susceptible individuals

Precautions & Warnings

Before using Melatonina Noxarem, consider the following safety measures.

  • Medical supervision: use under the guidance of a healthcare professional.
  • Age restrictions: not recommended for children unless specifically prescribed.
  • Driving and machinery: avoid operating vehicles or heavy equipment if drowsiness occurs.
  • Drug interactions: monitor use with other central nervous system depressants.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Melatonin can interact with several medication classes; monitoring is advised.

Major Interactions (Avoid)

  • Benzodiazepines or other sedatives: may cause excessive sedation.
  • Anticoagulants (e.g., warfarin): potential alteration of clotting parameters.
  • Immunosuppressants (e.g., cyclosporine): may affect melatonin metabolism.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): possible increase in serotonergic effects.
  • Antihypertensive agents: melatonin may modestly lower blood pressure.
  • Oral contraceptives: may alter hormone levels and melatonin clearance.

Frequently Asked Questions

Melatonina Noxarem contains melatonin, an over‑the‑counter agent that helps regulate the sleep‑wake cycle. It is commonly used to manage insomnia, alleviate jet lag, and support sleep in individuals with shift‑work related disturbances.

Melatonin mimics the body’s natural hormone released in darkness. By activating MT1 and MT2 receptors in the brain’s master clock, it signals that night has begun, reducing alertness, lowering core body temperature, and facilitating the onset and maintenance of sleep.

The appropriate dose of Melatonina Noxarem is determined by a prescriber based on the individual’s age, condition, and response. Patients should follow the healthcare professional’s instructions and not exceed the recommended amount.

Safety data for melatonin use in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Melatonin differs from traditional hypnotics such as benzodiazepines or Z‑drugs because it works by normalising the body’s circadian rhythm rather than directly depressing the central nervous system. It generally has a lower risk of dependence and fewer cognitive side effects, but its efficacy may be modest for severe insomnia.

Store Melatonina Noxarem at temperatures below 25 °C, in its original container, protected from moisture and direct sunlight. Proper storage helps maintain potency and ensures product stability throughout its shelf life.

Melatonina Noxarem is taken orally, typically with a glass of water. For best results, it is usually taken about 30‑60 minutes before the desired bedtime, unless otherwise directed by a healthcare professional.

Serious but rare risks include severe allergic reactions (rash, swelling, difficulty breathing) and pronounced daytime drowsiness that can impair driving or operating machinery. Any unexpected or severe symptoms should prompt immediate medical attention.

Individuals with known hypersensitivity to melatonin or any excipients in the product should avoid it. People taking certain medications (e.g., strong CNS depressants, anticoagulants) should consult a clinician before use, and it is not recommended for children unless specifically prescribed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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