Product image of Melatonina Noxarem (Melatonin) supplied by GNH India

Melatonina Noxarem

Active Ingredient:
Melatonin
Origin:
EU

Melatonina Noxarem (Melatonin)

Melatonin, the active ingredient in Melatonina Noxarem, is a melatonin receptor agonist presented as an oral formulation for oral use. It is used to help regulate the sleep‑wake cycle and is indicated for individuals experiencing insomnia, jet lag, or other sleep‑wake rhythm disturbances. Classified under the therapeutic class of sleep disorders, melatonin binds to MT1 and MT2 receptors in the brain to promote sleep onset.

GNH India supplies Melatonina Noxarem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vemedia Manufacturing B. V.

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Indications & Clinical Uses

Melatonina Noxarem is a melatonin receptor agonist used to address disorders of the sleep‑wake cycle.

  • Insomnia: helps reduce time to fall asleep and improve sleep continuity.
  • Jet lag: assists in adjusting circadian rhythm after rapid time‑zone travel.
  • Sleep‑wake rhythm disorders: supports normalization of abnormal sleep patterns.

How It Works

  • Melatonin acts as an agonist at the MT1 and MT2 melatonin receptors located in the suprachiasmatic nucleus of the hypothalamus. Activation of these G‑protein‑coupled receptors modulates intracellular cyclic AMP levels, leading to phase‑shifting of the circadian clock and facilitating the initiation of sleep. By mimicking endogenous melatonin, the drug helps synchronize the body's internal timing with the external light‑dark cycle.

Side Effects

Melatonina Noxarem may be associated with several adverse reactions, most of which are mild and transient.

Common Side Effects

  • Drowsiness: feeling of sleepiness during daytime.
  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness or imbalance.
  • Gastrointestinal discomfort: nausea or stomach upset.
  • Vivid dreams: unusually intense or memorable dreams.
  • Fatigue: general lack of energy.
  • Excessive night‑time sleepiness: pronounced sleepiness after taking the dose.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Mood changes: depression or increased anxiety.
  • Hormonal effects: alterations in menstrual cycle or reproductive hormones.
  • Cardiac arrhythmia: irregular heart rhythm (very rare).
  • Severe hypotension: marked drop in blood pressure (very rare).

Precautions & Warnings

When using Melatonina Noxarem, certain precautions should be observed to ensure safe and effective therapy.

  • Assess medical history: review sleep disorders, psychiatric conditions, and cardiovascular disease.
  • Use with caution in the elderly: increased sensitivity to sedative effects.
  • Avoid operating machinery: drowsiness may impair alertness.
  • Monitor for hormonal effects: especially in patients of reproductive age.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Melatonina Noxarem can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): reduced drug levels.
  • Central nervous system depressants (e.g., benzodiazepines): excessive sedation.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in contraceptive effectiveness.
  • Antidiabetic agents: potential alteration of glucose control.
  • CYP1A2 inhibitors (e.g., fluvoxamine): increased melatonin concentrations.

Frequently Asked Questions

Melatonina Noxarem is used to help regulate the sleep‑wake cycle in individuals who have difficulty falling or staying asleep. It is indicated for conditions such as insomnia, jet lag after rapid travel across time zones, and other sleep‑wake rhythm disorders where the body’s internal clock is out of sync.

Melatonin works by binding to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. This activation influences the circadian signaling pathways, reduces the production of wake‑promoting neurotransmitters, and facilitates the onset of sleep, thereby helping to align the body’s internal clock with the external light‑dark cycle.

The appropriate dose of Melatonina Noxarem is determined by a qualified healthcare professional based on the patient’s age, condition, and response to therapy. Prescribers select the strength and timing that best suit the individual’s needs; no standard dose is provided here.

Safety data for melatonin use during pregnancy or lactation are limited. Healthcare providers generally advise caution and may recommend avoiding the product unless the potential benefit outweighs any possible risk. Patients should discuss their specific situation with a physician before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Melatonina Noxarem. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Melatonin differs from traditional sedative hypnotics such as benzodiazepines or Z‑drugs because it targets the body’s natural circadian mechanisms rather than directly depressing the central nervous system. This generally results in a lower risk of dependence and fewer cognitive side effects, though individual response can vary.

Store Melatonina Noxarem at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain potency throughout its shelf life.

Melatonina Noxarem is taken orally, typically with a glass of water. It is usually administered shortly before the desired bedtime or, in the case of jet lag, at the target night‑time of the new time zone. Exact timing should follow the prescriber’s instructions.

Serious adverse reactions, although rare, include severe allergic responses such as rash, swelling, or breathing difficulty, and significant mood changes like depression or heightened anxiety. Any signs of an allergic reaction or unexpected psychiatric symptoms should prompt immediate medical evaluation.

Individuals with known hypersensitivity to melatonin or any excipients in the formulation should avoid the product. Patients with uncontrolled hypertension, severe depression, or those taking medications that have major interactions with melatonin (e.g., certain anticoagulants) should consult a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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