Product image of Melatonina Pharma Nord (Melatonin) supplied by GNH India

Melatonina Pharma Nord

Active Ingredient:
Melatonin
Origin:
EU

Melatonina Pharma Nord (Melatonin)

Melatonin, the active ingredient in Melatonina Pharma Nord, is a melatonin receptor agonist presented as an oral tablet for oral use. It helps regulate circadian rhythm and promote sleep onset in adults and adolescents with sleep disorders.

GNH India supplies Melatonina Pharma Nord as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharma Nord Aps (Vojens)

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Indications & Clinical Uses

  • Melatonin acts on melatonin receptors to address disorders of the sleep‑wake cycle.
  • Insomnia: Improves sleep onset and maintenance in individuals who have difficulty falling or staying asleep.
  • Delayed sleep phase disorder: Helps advance circadian timing and facilitates earlier sleep.
  • Jet lag: Reduces the time required to adjust to new time zones and enhances sleep quality.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking the endogenous hormone. Activation of these G‑protein‑coupled receptors modulates the circadian clock, decreases neuronal firing during the night, and promotes the physiological processes that initiate and maintain sleep.

Side Effects

Melatonin is generally well tolerated, but some users experience adverse reactions.

Common Side Effects

  • Drowsiness or daytime sleepiness
  • Headache
  • Dizziness
  • Nausea
  • Mild gastrointestinal discomfort
  • Vivid dreams

Serious or Rare Side Effects

  • Allergic reaction (rash, swelling, itching)
  • Mood changes such as depression or irritability
  • Hormonal effects including alterations in reproductive hormone levels
  • Severe hypotension (very low blood pressure)
  • Rare cases of seizures in predisposed individuals

Precautions & Warnings

When considering melatonin therapy, several safety aspects should be reviewed.

  • Pregnancy: Safety not established; use only if clearly needed.
  • Breastfeeding: Caution advised; limited data available.
  • Age: Use lower doses in children; pediatric safety not fully defined.
  • Drug interactions: Review concomitant medications that affect CYP enzymes.
  • Medical conditions: Caution in patients with depression or seizure disorders.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Melatonin may interact with other medicines; some combinations require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Anticoagulants: May increase bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): May reduce melatonin metabolism.
  • Sedatives: Additive central nervous system depressant effect.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inhibitors (e.g., fluvoxamine): May increase melatonin plasma levels.
  • CYP1A2 inducers (e.g., rifampicin): May reduce melatonin efficacy.
  • Oral contraceptives: May alter melatonin pharmacokinetics.

Frequently Asked Questions

Melatonina Pharma Nord contains melatonin, which is used to help regulate the sleep‑wake cycle. It is indicated for conditions such as insomnia, delayed sleep phase disorder, and jet lag, where it can promote faster sleep onset and improve overall sleep quality.

Melatonin acts as an agonist at the MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. By binding these receptors, it signals the body that it is nighttime, helping to synchronize circadian rhythms and facilitate the transition to sleep.

The appropriate dose of melatonin is individualized. A prescriber determines the strength and frequency based on the patient’s age, the specific sleep disorder being treated, and any other relevant clinical factors.

Safety data for melatonin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk, and this decision must be made by a qualified health professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Melatonin differs from traditional hypnotics because it works by mimicking a natural hormone rather than depressing the central nervous system. It is generally considered for short‑term or circadian‑related sleep disturbances, whereas benzodiazepines or non‑benzodiazepine hypnotics are used for broader insomnia indications.

The product should be stored at ambient temperature, below 25 °C, in its original packaging. Protect it from excess moisture, direct sunlight and extreme temperatures to maintain potency.

Melatonina Pharma Nord is taken orally, typically with a glass of water. It is usually taken shortly before the desired bedtime, following the dosage instructions provided by the prescribing clinician.

Serious but rare risks include severe allergic reactions, significant mood changes such as depression or irritability, and hormonal disturbances that could affect reproductive function. Patients should seek medical attention if they experience any of these symptoms.

Melatonin should be avoided in individuals with known hypersensitivity to melatonin, those taking certain anticoagulants or immunosuppressants without medical supervision, and patients with uncontrolled depression or seizure disorders unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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