Product image of Melatonina Zentiva (Melatonin) supplied by GNH India

Melatonina Zentiva

Active Ingredient:
Melatonin
Origin:
EU

Melatonina Zentiva (Melatonin)

Melatonin, the active ingredient in Melatonina Zentiva, is a hormone presented as an oral tablet for oral administration. It regulates the circadian rhythm and is indicated for the short‑term management of sleep disturbances such as insomnia and jet lag in adults.

GNH India supplies Melatonina Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution across EU and other regulated markets. The product complies with EU pharmacopeial standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Zentiva Italia S.R.L.

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Indications & Clinical Uses

Melatonin acts on the melatonin receptor pathway to address sleep‑related disorders.

  • Insomnia: facilitates faster sleep onset and may improve sleep quality in adults.
  • Jet lag: aids in resetting the internal clock to reduce sleep‑wake disturbances after trans‑meridian travel.
  • Shift work disorder: supports adjustment of sleep timing for individuals with irregular work schedules.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking the endogenous hormone. This activation synchronises the circadian clock, reduces neuronal firing during the night, and promotes the physiological processes that initiate sleep, thereby facilitating sleep onset and maintenance.

Side Effects

Melatonin is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

  • Drowsiness: feeling unusually sleepy during the day.
  • Headache: mild to moderate pain in the head.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: mild stomach upset.
  • Vivid dreams: unusually intense or memorable dreams.
  • Mild gastrointestinal discomfort: occasional stomach cramps or bloating.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, swelling of the face or throat.
  • Mood changes: depression, irritability, or anxiety.
  • Hormonal effects: menstrual irregularities in women.
  • Severe hypersensitivity: anaphylaxis requiring emergency care.
  • Suicidal thoughts: rare emergence of self‑harm ideation.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before using Melatonina Zentiva, consider the following safety measures.

  • Assess sleep pattern: evaluate underlying causes before use.
  • Avoid driving: potential residual drowsiness may impair performance.
  • Use with caution in elderly: increased sensitivity to sedative effects.
  • Review concomitant medications: possible interactions with anticoagulants, immunosuppressants, or CNS depressants.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Melatonin may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): may reduce efficacy.
  • CNS depressants (e.g., benzodiazepines): additive sedative effect.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inhibitors (e.g., fluvoxamine): may raise melatonin plasma levels.
  • Oral contraceptives: may alter hormone balance.
  • Antidepressants (e.g., SSRIs): potential for increased side effects.

Frequently Asked Questions

Melatonina Zentiva contains melatonin, a hormone that helps regulate the body’s circadian rhythm. It is used to manage short‑term sleep disturbances such as insomnia and jet lag, supporting the ability to fall asleep more quickly and maintain a regular sleep‑wake cycle.

Melatonin acts as an agonist at MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. By binding these receptors, it signals nighttime to the body, synchronising the internal clock and promoting physiological processes that initiate and sustain sleep.

The appropriate dose of Melatonina Zentiva is determined by a qualified healthcare professional based on the individual’s age, condition, and response. Prescribers set the regimen, and patients should follow the specific instructions provided on the prescription label.

Safety data for melatonin use in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Melatonina Zentiva.

To request Melatonina Zentiva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Melatonina Zentiva differs from prescription hypnotics such as zolpidem because it is a physiological hormone rather than a synthetic sedative. It generally has a milder side‑effect profile and is intended for short‑term use, whereas prescription agents may be stronger but carry higher risks of dependence and next‑day impairment.

Store Melatonina Zentiva at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

Melatonina Zentiva is taken orally, usually with a glass of water. For optimal effect, it is commonly taken 30‑60 minutes before the desired bedtime, following the timing instructions provided by the prescriber.

Serious adverse reactions, although rare, include severe allergic responses such as rash, swelling, or anaphylaxis, as well as mood alterations like depression or suicidal thoughts. Any signs of a severe reaction require immediate medical attention.

Individuals with known hypersensitivity to melatonin or any excipients in the tablet should avoid use. Caution is also advised for patients taking anticoagulants, immunosuppressants, or CNS depressants, and for those with uncontrolled psychiatric conditions unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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