Product image of Melatonine (Melatonin) supplied by GNH India

Melatonine

Active Ingredient:
Melatonin
Origin:
EU

Melatonine (Melatonin)

Melatonin, the active ingredient in Melatonine, is a melatonin receptor agonist presented as an oral formulation for oral use. It treats insomnia and related sleep‑wake rhythm disorders in adults.

GNH India supplies Melatonine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharma Nord Aps (Vojens)

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Indications & Clinical Uses

Melatonin acts on the melatonin receptor pathway to regulate circadian rhythm and support normal sleep patterns.

  • Insomnia: helps initiate and maintain sleep in individuals with difficulty falling asleep.
  • Sleep‑wake rhythm disorders: assists in normalising disrupted sleep cycles such as delayed sleep phase.
  • Jet lag: reduces the time needed to adjust to new time zones after long‑distance travel.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking the endogenous hormone that signals darkness. This activation modulates the circadian clock, reduces neuronal firing that promotes wakefulness, and facilitates the transition to sleep, thereby supporting normal sleep onset and maintenance.

Side Effects

Melatonin is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

  • Drowsiness during daytime
  • Headache
  • Dizziness
  • Nausea
  • Vivid dreams
  • Mild gastrointestinal discomfort

Serious or Rare Side Effects

  • Allergic skin reactions (rash, itching)
  • Mood changes (depression, anxiety)
  • Hormonal disturbances (menstrual irregularities)
  • Severe hypersensitivity (anaphylaxis, though extremely rare).

Precautions & Warnings

Before using melatonin, consider the following safety points.

  • Pregnancy: consult a healthcare professional as safety data are limited.
  • Breastfeeding: discuss potential exposure with a physician.
  • Pediatric use: only under medical supervision.
  • Concomitant CNS depressants: monitor for enhanced sedation.
  • Underlying medical conditions: inform your doctor of any chronic illnesses.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Melatonin may interact with other medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): could reduce drug efficacy.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines, alcohol): may enhance drowsiness.
  • Oral contraceptives: melatonin may affect hormone levels.
  • Antidiabetic agents: possible alteration of glucose control.
  • Antihypertensives: monitor blood pressure changes.

Frequently Asked Questions

Melatonine contains melatonin, which is used to help manage insomnia, sleep‑wake rhythm disorders such as delayed sleep phase, and jet lag caused by rapid travel across time zones. It works by supporting the body’s natural sleep‑regulating mechanisms.

Melatonin binds to MT1 and MT2 receptors in the brain’s master clock, signalling darkness and promoting the transition from wakefulness to sleep. This receptor activation helps synchronise the circadian rhythm, making it easier to fall asleep and stay asleep.

The appropriate dose of Melatonine is determined by a prescriber based on the individual’s age, health status, and specific sleep condition. Healthcare professionals tailor the amount to achieve the desired therapeutic effect while minimising any potential side effects.

Safety data for melatonin use in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Melatonine.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike prescription hypnotics that act on GABA receptors, melatonin works by mimicking the body’s natural hormone to regulate circadian timing. It is generally considered milder, with a lower risk of dependence, making it a preferred option for short‑term sleep disturbances and jet‑lag management.

Melatonine should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain potency.

Melatonine is taken orally, typically as a tablet or capsule, with water. It is usually taken shortly before bedtime, following the dosage instructions provided by a healthcare professional.

Serious but rare risks include severe allergic reactions such as rash, itching, swelling, or anaphylaxis. Users should also be aware of possible hormonal disturbances and mood changes, and seek medical attention if any concerning symptoms develop.

Individuals with known hypersensitivity to melatonin, those taking certain anticoagulants or immunosuppressants without medical supervision, and children or adolescents unless prescribed by a clinician should avoid using Melatonine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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