Melatonine Adoh (Melatonin)

Melatonine Adoh acts on melatonin receptors to support normal circadian rhythm and improve sleep quality.

• Insomnia: facilitates sleep onset and reduces nighttime awakenings.
• Jet lag: helps synchronize the internal clock after rapid time‑zone travel.
• Sleep‑wake rhythm disorders: stabilises abnormal sleep patterns in shift‑workers or individuals with delayed sleep phase syndrome.

• Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking endogenous melatonin. This activation modulates circadian signaling pathways, lowers core body temperature, and promotes the physiological processes that initiate sleep, thereby facilitating a more regular sleep‑wake cycle.

Melatonin is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

• Drowsiness or daytime sleepiness
• Headache
• Dizziness
• Nausea or mild gastrointestinal discomfort
• Vivid dreams or altered dream patterns
• Mild abdominal cramps

Serious or Rare Side Effects

• Allergic reactions such as rash, itching or facial swelling
• Severe dizziness or vertigo
• Mood changes including depression or anxiety
• Abnormal heart rhythm or palpitations
• Hallucinations or confusion
• Severe gastrointestinal upset or vomiting

Before using Melatonine Adoh, consider the following safety measures.

• Diagnose accurately: confirm the specific sleep disorder before initiating therapy.
• Concomitant CNS depressants: assess risk when combined with alcohol, benzodiazepines or antihistamines.
• Hepatic impairment: use caution in patients with liver disease as metabolism may be altered.
• Driving and machinery: avoid operating vehicles or heavy equipment until individual response is known.
• Elderly patients: start with the lowest effective dose and monitor for excessive sedation.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Melatonin can influence the activity of several other medicines; interaction severity varies.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): may increase bleeding risk.
• CNS depressants (alcohol, benzodiazepines): can enhance sedative effects.
• CYP1A2 inhibitors (fluvoxamine, ciprofloxacin): may raise melatonin plasma levels.
• Immunosuppressants (tacrolimus, cyclosporine): potential alteration of drug concentrations.
• Antiplatelet agents (aspirin, clopidogrel): possible additive effect on bleeding.

Moderate Interactions (Monitor Closely)

• Oral contraceptives: melatonin may reduce contraceptive efficacy.
• Antidiabetic drugs: monitor blood glucose as melatonin can affect glycaemic control.
• Antihypertensives: possible additive blood‑pressure lowering effect.
• NSAIDs: watch for increased gastrointestinal irritation.
• Antidepressants (SSRIs, SNRIs): may alter sleep architecture when combined.