Product image of Melatonine Orifarm (Melatonin) supplied by GNH India

Melatonine Orifarm

Active Ingredient:
Melatonin
Origin:
EU

Melatonine Orifarm (Melatonin)

Melatonin, the active ingredient in Melatonine Orifarm, is a melatonin receptor agonist presented as an oral formulation for oral use. It is employed to help regulate the sleep‑wake cycle and to support the onset of sleep in adults with insomnia or related circadian rhythm disturbances.

GNH India supplies Melatonine Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for importers. Products are shipped in compliance with Good Distribution Practice and can be tracked throughout the supply chain.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Melatonine Orifarm is a melatonin receptor agonist used to treat sleep‑related disorders by influencing circadian rhythm regulation.

  • Insomnia: improves sleep onset and reduces nighttime awakenings.
  • Sleep‑wake rhythm disorder: helps synchronize the internal clock with external light‑dark cycles.
  • Delayed sleep phase disorder: advances sleep timing to achieve a more conventional bedtime.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking the endogenous hormone. Activation of these G‑protein‑coupled receptors modulates intracellular cyclic AMP levels, leading to phase‑shift adjustments of the circadian pacemaker and facilitating the transition to sleep.

Side Effects

Melatonine Orifarm may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Dizziness: transient sense of light‑headedness.
  • Daytime sleepiness: feeling unusually tired during waking hours.
  • Nausea: mild gastrointestinal upset.
  • Vivid dreams: unusually intense or memorable dreams.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Severe mood changes: depression or suicidal thoughts.
  • Hormonal effects: menstrual irregularities or decreased libido.

Precautions & Warnings

When considering Melatonine Orifarm, several precautionary measures should be observed to ensure safe use.

  • Medical history review: assess liver function and existing sleep disorders.
  • Concomitant CNS depressants: avoid combining with benzodiazepines or alcohol.
  • Hepatic impairment: use with caution and monitor response.
  • Pediatric use: not recommended unless specifically prescribed.
  • Mood monitoring: watch for signs of depression or anxiety.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Melatonin can interact with other medicines, altering its effectiveness or increasing the risk of adverse events.

Major Interactions (Avoid)

  • Central nervous system depressants: may enhance sedative effects.
  • Anticoagulants: potential increase in bleeding risk.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inhibitors (e.g., fluvoxamine): may raise melatonin levels.
  • CYP2C19 inhibitors (e.g., omeprazole): may increase exposure.
  • Antihypertensives: possible additive blood‑pressure lowering.
  • Oral contraceptives: may reduce contraceptive efficacy.
  • NSAIDs: may slightly increase bleeding tendency.

Frequently Asked Questions

Melatonine Orifarm contains melatonin, which is used to manage insomnia and other sleep‑wake rhythm disorders by helping to reset the body’s internal clock and promote the onset of sleep.

Melatonin acts as an agonist at MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. This interaction adjusts circadian signaling, reduces alertness, and facilitates the transition from wakefulness to sleep.

The appropriate dose is determined by the prescribing healthcare professional based on the individual’s condition, age, and response. Patients should follow the prescriber’s instructions and not self‑adjust the dosage.

Safety data for melatonin in pregnancy and lactation are limited. Healthcare providers should evaluate the risk‑benefit profile before prescribing it to pregnant or nursing individuals.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike benzodiazepines or antihistamines, melatonin targets the body’s natural sleep‑regulating pathway, offering a non‑sedative approach that aligns with the circadian rhythm. It generally has a more favorable side‑effect profile but may be less potent for acute insomnia.

Store at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use.

The product is taken orally, usually as a tablet or capsule, and is typically consumed shortly before bedtime as directed by a healthcare professional.

Serious risks include allergic reactions such as rash, swelling or breathing difficulties, and rare but significant mood changes like depression or suicidal thoughts. Any of these symptoms require immediate medical attention.

Individuals with known hypersensitivity to melatonin, those taking interacting CNS depressants or anticoagulants without medical supervision, and patients with uncontrolled hepatic disease should avoid using this product unless advised otherwise by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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