Product image of Melatonine Pharma Nord (Melatonin) supplied by GNH India

Melatonine Pharma Nord

Active Ingredient:
Melatonin
Origin:
EU

Melatonine Pharma Nord (Melatonin)

Melatonin, the active ingredient in Melatonine Pharma Nord, is a melatonin receptor agonist presented as an oral dosage form for oral use. It is used to help regulate sleep timing in individuals with insomnia, jet lag, or circadian rhythm disturbances.
GNH India supplies Melatonine Pharma Nord as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharma Nord Aps (Vojens)

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Indications & Clinical Uses

  • Melatonin acts on the melatonin receptor pathway to regulate sleep timing.
  • Insomnia: helps initiate sleep and improve sleep continuity in adults who have difficulty falling asleep.
  • Jet lag: reduces the time needed to adjust to new time zones and alleviates associated fatigue.
  • Sleep-wake rhythm disorders: supports alignment of the circadian rhythm in shift‑work or delayed sleep phase syndrome.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking the endogenous hormone that signals darkness. Activation of these G‑protein‑coupled receptors modulates intracellular cyclic AMP and calcium pathways, leading to a phase‑shift of the circadian clock and promotion of sleep onset.

Side Effects

Melatonin is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache
  • Dizziness
  • Daytime sleepiness
  • Nausea
  • Vivid dreams

Serious or Rare Side Effects

  • Allergic reaction (rash, swelling, difficulty breathing)
  • Severe rash or Stevens‑Johnson syndrome
  • Mood changes including depression or suicidal thoughts
  • Rare cardiac arrhythmias

Precautions & Warnings

Use melatonin with consideration of individual health status and potential interactions.

  • Assess sleep pattern before initiating therapy: confirm that insomnia is not due to an underlying medical condition.
  • Avoid use with shift‑work schedules unless directed by a clinician.
  • Monitor for excessive daytime drowsiness, especially when driving or operating machinery.
  • Caution in patients with a history of depression or mood disorders.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Melatonin may interact with other medicines; review patient medication lists.

Major Interactions (Avoid)

  • Concurrent use with central nervous system depressants (e.g., benzodiazepines) may increase sedation.
  • Interaction with anticoagulants such as warfarin may alter bleeding risk.

Moderate Interactions (Monitor Closely)

  • Fluvoxamine can raise melatonin plasma concentrations.
  • Caffeine may diminish melatonin’s sleep‑promoting effect.
  • Antihypertensive agents may experience additive blood‑pressure‑lowering effects.

Frequently Asked Questions

Melatonine Pharma Nord contains melatonin, a hormone that helps regulate the body’s sleep‑wake cycle. It is commonly used to treat insomnia, reduce the effects of jet lag after rapid travel across time zones, and manage sleep‑wake rhythm disorders such as delayed sleep phase syndrome.

Melatonin binds to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus, signalling that it is nighttime. This interaction shifts the circadian clock, lowers alertness, and facilitates the onset of sleep, helping the body align its internal rhythm with external darkness.

The appropriate dose is individualized and set by a prescriber based on the patient’s age, the specific sleep condition being treated, and any concurrent medications. Clinicians may start with a low dose and adjust as needed to achieve the desired sleep benefit.

Safety data for melatonin use in pregnancy and lactation are limited, and the product does not have an established pregnancy category. Healthcare providers usually recommend avoiding melatonin during pregnancy or while breastfeeding unless the potential benefit outweighs the uncertain risk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Melatonin differs from traditional sedative hypnotics such as benzodiazepines or Z‑drugs because it works by resetting the circadian clock rather than directly depressing the central nervous system. It generally has a lower risk of dependence and fewer cognitive side effects, but its efficacy is most pronounced for circadian‑related sleep disturbances.

Store the product at room temperature, preferably below 25 °C. Keep it in the original packaging to protect it from moisture and light, and ensure the container is tightly closed after each use to maintain product stability.

Melatonine Pharma Nord is taken orally, usually with a glass of water. It is typically taken 30‑60 minutes before the desired bedtime, but the exact timing should follow the prescribing clinician’s instructions.

While rare, serious adverse reactions can include allergic responses such as rash, swelling, or difficulty breathing, as well as mood changes like depression or suicidal thoughts. Any signs of severe reaction should prompt immediate medical attention.

Melatonin should be avoided in individuals with known hypersensitivity to melatonin, those taking monoamine oxidase inhibitors without medical supervision, and patients with uncontrolled depression or severe psychiatric disorders unless a physician determines it is appropriate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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