Product image of Melet (Pheniramine Maleate, Tetryzoline Hydrochloride) supplied by GNH India

Melet

Active Ingredient:
Pheniramine Maleate, Tetryzoline Hydrochloride
Origin:
EU

Melet (Pheniramine Maleate, Tetryzoline Hydrochloride)

Pheniramine maleate and tetryzoline hydrochloride, the active ingredients in Melet, are an antihistamine and an alpha‑adrenergic agonist presented as eye drops for ocular use. They treat allergic conjunctivitis, eye itching, and redness in patients with ocular allergy.

GNH India supplies Melet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Genetic Spa

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Indications & Clinical Uses

  • Melet acts on ocular allergic pathways to relieve symptoms of eye inflammation and irritation.
  • Allergic conjunctivitis: reduces itching, redness and swelling of the conjunctiva.
  • Eye itching: alleviates pruritus caused by allergic eye disease.
  • Conjunctival hyperemia: diminishes vascular redness and improves visual comfort.

How It Works

  • Pheniramine maleate blocks H1 histamine receptors, limiting histamine‑mediated itching and vasodilation in the eye. Tetryzoline hydrochloride stimulates alpha‑adrenergic receptors on conjunctival vessels, producing vasoconstriction that reduces hyperemia and swelling. The combined actions provide rapid relief of ocular allergy symptoms.

Side Effects

Common Side Effects

  • Stinging or burning sensation upon instillation.
  • Transient blurred vision lasting a few minutes.
  • Mild eye irritation or redness.
  • Temporary increase in tearing.
  • Mild headache in some users.

Serious or Rare Side Effects

  • Severe allergic reaction such as anaphylaxis.
  • Significant increase in intra‑ocular pressure.
  • Prolonged vasoconstriction leading to ocular ischemia.
  • Corneal ulceration or epithelial damage.
  • Persistent eye pain or vision loss.

Precautions & Warnings

Before using Melet, consider the following safety measures.

  • Hypersensitivity: avoid if you have known allergy to pheniramine, tetryzoline or any excipient.
  • Glaucoma: use with caution in patients with narrow‑angle glaucoma.
  • Duration: do not exceed the recommended treatment period (typically 3‑5 days) to prevent rebound hyperemia.
  • Contact lenses: avoid wearing lenses during treatment and remove them before instillation.
  • Pediatric use: monitor children closely for systemic absorption signs.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Melet may interact with other medicines; review the following.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: risk of hypertensive crisis.
  • Other ocular vasoconstrictors: may cause excessive vasoconstriction and ischemia.
  • Systemic alpha‑adrenergic agonists: additive blood‑pressure effects.

Moderate Interactions (Monitor Closely)

  • Concurrent topical ocular medications: possible reduced efficacy or irritation.
  • Contact lens solutions: may affect drug stability; rinse lenses before use.
  • Systemic antihistamines: potential additive sedation or anticholinergic load.

Frequently Asked Questions

Melet is an over‑the‑counter eye‑drop formulation that combines pheniramine maleate and tetryzoline hydrochloride to relieve symptoms of allergic conjunctivitis, such as itching, redness, and swelling of the conjunctiva.

Pheniramine maleate acts as an H1‑receptor antagonist, blocking histamine binding in ocular tissues. This reduces histamine‑mediated itching, vasodilation, and inflammatory fluid leakage, providing rapid symptom relief.

The appropriate dosing regimen for Melet is determined by the prescribing healthcare professional. Typically, one to two drops are instilled in the affected eye(s) as directed, not exceeding the recommended treatment duration.

Safety data for pheniramine maleate and tetryzoline hydrochloride in pregnancy and lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should consult their physician before using Melet.

To order Melet, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Melet combines an antihistamine (pheniramine) with a vasoconstrictor (tetryzoline), offering both itch relief and rapid reduction of redness. Single‑agent antihistamine drops relieve itching but may not address hyperemia as quickly, while pure vasoconstrictors lack the antihistamine component for itch control.

Store Melet at room temperature, below 25 °C, in the original packaging. Keep the bottle tightly closed, protect it from direct sunlight and moisture to maintain product stability.

Melet is applied topically as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place the prescribed number of drops into the conjunctival sac. Close the eye gently and avoid blinking excessively.

Serious risks include severe allergic reactions (anaphylaxis), significant rise in intra‑ocular pressure, prolonged vasoconstriction leading to ocular ischemia, and corneal ulceration. Any sudden vision changes or intense eye pain should prompt immediate medical attention.

Melet should not be used by individuals with known hypersensitivity to pheniramine, tetryzoline, or any formulation excipients, and it is contraindicated in patients with narrow‑angle glaucoma or recent ocular surgery unless directed by an eye specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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