Product image of Melfalan Teva (Melphalan) supplied by GNH India

Melfalan Teva

Active Ingredient:
Melphalan
Origin:
EU

Melfalan Teva (Melphalan)

Melphalan, the active ingredient in Melfalan Teva, is a Alkylating agent presented as a unknown/unknown for Intravenous use. It is used to treat certain cancers such as multiple myeloma, ovarian cancer, malignant melanoma and neuroblastoma.
GNH India supplies Melfalan Teva as a licensed, GDP-compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Melfalan Teva (melphalan) is an alkylating antineoplastic agent used in the treatment of several solid tumours and hematologic malignancies.

  • Multiple myeloma: improves disease control and prolongs survival.
  • Ovarian cancer: incorporated into combination chemotherapy to reduce tumour burden.
  • Malignant melanoma: employed in high‑dose regimens for advanced disease.
  • Neuroblastoma: used in intensive protocols for high‑risk pediatric cases.

How It Works

  • Melphalan exerts its antineoplastic activity by forming covalent cross‑links between DNA strands. These cross‑links prevent DNA replication and transcription, leading to cell cycle arrest and apoptosis of rapidly dividing cancer cells. The drug preferentially targets proliferating cells because of their limited capacity for DNA repair, resulting in selective tumour cytotoxicity.

Side Effects

Adverse reactions to melphalan are common and can affect multiple organ systems.

Common Side Effects

  • Nausea and vomiting.
  • Myelosuppression (decreased white blood cells, red blood cells, and platelets).
  • Alopecia (hair loss).
  • Fatigue.
  • Mucositis (inflammation of the mouth lining).
  • Diarrhoea.

Serious or Rare Side Effects

  • Severe neutropenia leading to infection.
  • Thrombocytopenia causing bleeding complications.
  • Pulmonary toxicity such as interstitial pneumonitis.
  • Secondary malignancies (e.g., therapy‑related leukaemia).
  • Renal impairment.
  • Cardiac arrhythmias.

Precautions & Warnings

When using melphalan, careful monitoring and patient education are essential to minimise risks.

  • Blood counts: monitor complete blood count regularly to detect myelosuppression.
  • Renal function: assess serum creatinine and adjust therapy if needed.
  • Pulmonary status: evaluate for signs of respiratory distress or pneumonitis.
  • Hypersensitivity: discontinue if an allergic reaction occurs.
  • Contraception: advise both male and female patients to use effective contraception during treatment and for a defined period after.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Melphalan may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Concurrent use with other alkylating agents (increased toxicity).
  • High‑dose radiation therapy (enhanced tissue damage).
  • Live vaccines (risk of infection due to immunosuppression).
  • Strong CYP450 inducers (may reduce plasma levels, though melphalan is not primarily metabolised by CYP enzymes).

Moderate Interactions (Monitor Closely)

  • Anticoagulants (enhanced bleeding risk).
  • Nephrotoxic drugs such as aminoglycosides (potential renal impairment).
  • Immunosuppressants (additive suppression of bone marrow).

Frequently Asked Questions

Melfalan Teva (melphalan) is indicated for the treatment of several cancers, including multiple myeloma, ovarian cancer, malignant melanoma and neuroblastoma. It is administered as part of chemotherapy regimens designed to control tumour growth and improve patient outcomes.

Melphalan belongs to the alkylating agent class. It creates covalent bonds between DNA strands, forming cross‑links that block DNA replication and transcription. This interference triggers cell cycle arrest and ultimately leads to apoptosis of rapidly dividing cancer cells.

The dosage of Melfalan Teva is individualized by the prescribing oncologist based on the specific cancer type, disease stage, patient weight, renal function and treatment protocol. Only a qualified healthcare professional can determine the appropriate dose and schedule.

Melphalan is classified as a potent cytotoxic agent and may cause fetal harm. It is generally contraindicated during pregnancy and should not be used by breastfeeding mothers because it can be excreted in milk. Patients should discuss family planning with their physician before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Melphalan is an alkylating agent, distinct from antimetabolites, taxanes or anthracyclines. Compared with other alkylators, it has a broad spectrum against both solid tumours and hematologic malignancies but shares similar toxicity profiles, such as myelosuppression. Choice of therapy depends on tumour type, prior treatment history and patient tolerance.

Melfalan Teva should be stored at ambient temperature, below 25 °C, in its original packaging. The container should be kept away from moisture, direct sunlight and extreme temperatures to maintain product stability until preparation for intravenous administration.

Melfalan Teva is supplied for intravenous infusion. The drug is reconstituted according to the manufacturer's instructions and administered by a qualified healthcare professional, typically over a set period of time as defined by the treatment protocol.

Serious risks include severe myelosuppression leading to infection or bleeding, pulmonary toxicity such as interstitial pneumonitis, secondary malignancies, renal impairment and cardiac arrhythmias. Patients should be closely monitored for these complications throughout treatment.

Melfalan Teva is contraindicated in patients with known hypersensitivity to melphalan or any component of the formulation, in those receiving live vaccines, and in pregnant or breastfeeding individuals. Caution is also advised for patients with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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