Product image of Melfen (Ibuprofen) supplied by GNH India

Melfen

Active Ingredient:
Ibuprofen
Origin:
EU

Melfen (Ibuprofen)

Ibuprofen, the active ingredient in Melfen, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral dosage form for systemic use. It reduces pain, fever and inflammation and is commonly used in adults and children for conditions such as headache, dental pain, musculoskeletal disorders and febrile illnesses. It is available over‑the‑counter in many markets.

GNH India supplies Melfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Pannonpharma Kft.

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Indications & Clinical Uses

Ibuprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Mild to moderate pain: provides analgesia by lowering prostaglandin‑mediated nociception.
  • Fever: reduces elevated body temperature through central inhibition of prostaglandin synthesis.
  • Inflammatory conditions (e.g., osteoarthritis, rheumatoid arthritis): decreases joint swelling and stiffness by limiting inflammatory prostaglandins.

How It Works

  • Ibuprofen reversibly inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes peripheral sensitization of nociceptors, lowers fever set‑point in the hypothalamus, and reduces inflammation in affected tissues.

Side Effects

Adverse reactions may range from mild gastrointestinal discomfort to serious systemic events.

Common Side Effects

  • Nausea: occasional upset stomach after oral intake.
  • Dyspepsia: indigestion or heartburn.
  • Headache: mild to moderate intensity.
  • Dizziness: transient light‑headedness.
  • Rash: mild skin irritation.
  • Elevated liver enzymes: transient laboratory finding.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Acute renal failure or worsening of chronic kidney disease.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome).
  • Anaphylaxis: rapid onset of allergic symptoms.
  • Hepatotoxicity: rare liver injury.

Precautions & Warnings

Patients should consider several safety measures before using ibuprofen.

  • Assess gastrointestinal risk: avoid in individuals with active ulcers or a history of GI bleeding.
  • Monitor renal function: use caution in patients with impaired kidney function or dehydration.
  • Avoid use in the third trimester of pregnancy: may affect fetal cardiovascular system.
  • Use the lowest effective dose for the shortest duration needed.
  • Caution with concomitant anticoagulants or antiplatelet agents: increased bleeding risk.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Lithium: ibuprofen may increase lithium serum concentrations.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.
  • Diuretics: may exacerbate renal impairment.
  • Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency.
  • Corticosteroids: enhanced risk of gastrointestinal ulceration.
  • Beta‑blockers: potential attenuation of blood pressure control.

Frequently Asked Questions

Melfen contains ibuprofen, an NSAID indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions such as osteoarthritis and rheumatoid arthritis. It is commonly employed for headaches, dental discomfort, musculoskeletal aches, and febrile illnesses in both adult and pediatric populations when appropriate.

Ibuprofen works by reversibly blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it reduces peripheral pain signaling, lowers the hypothalamic set‑point for temperature, and diminishes inflammation in affected tissues.

The dosage of Melfen is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. The prescriber will select the appropriate strength, frequency, and duration in accordance with current clinical guidelines and regulatory labeling.

Ibuprofen is generally avoided during the third trimester of pregnancy because it may affect fetal cardiovascular development. Use in earlier trimesters should be under medical supervision. While small amounts pass into breast milk, it is usually considered compatible with breastfeeding if the benefit outweighs potential risk; a healthcare provider should evaluate each case.

To order Melfen, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements if applicable), and assists with import documentation.

Melfen (ibuprofen) shares the core anti‑inflammatory and analgesic properties of the NSAID class but differs in potency, half‑life, and safety profile. Compared with aspirin, ibuprofen has a lower risk of gastric irritation at standard doses. Relative to naproxen, ibuprofen’s shorter half‑life may require more frequent dosing but offers quicker onset of pain relief. Choice of NSAID should consider individual patient risk factors and therapeutic goals.

Melfen should be stored at room temperature, preferably below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. Do not store in bathrooms or near heat sources, and discard any product that shows signs of degradation such as discoloration or unusual odor.

Melfen is taken orally with a full glass of water. It may be taken with or without food; however, taking it with meals can reduce the likelihood of gastrointestinal discomfort. Swallow tablets or capsules whole; do not crush or chew unless the formulation specifically allows it. Follow the prescriber’s instructions regarding timing and frequency.

The most serious risks include gastrointestinal bleeding or ulceration, acute kidney injury, and increased cardiovascular events such as heart attack or stroke, especially with high‑dose or prolonged use. Rare but severe reactions can involve severe skin disorders (e.g., Stevens‑Johnson syndrome) and anaphylaxis. Patients should seek immediate medical attention if they experience signs of serious bleeding, severe rash, or breathing difficulties.

Melfen should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulceration or bleeding, severe heart failure, or advanced renal impairment. It is also contraindicated in the third trimester of pregnancy. Patients on anticoagulant therapy, certain antihypertensives, or those with a history of cardiovascular disease should consult a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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