Melferut (Etofenamate)

• Melferut, an NSAID applied to the skin, targets inflammatory pathways in musculoskeletal conditions.
• Musculoskeletal injuries: reduces pain and swelling in bruises, contusions and minor trauma.
• Sprains and strains: alleviates discomfort and promotes faster functional recovery.
• Localized skin inflammation: diminishes redness, heat and tenderness of superficial inflammatory lesions.

• Etofenamate inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes in peripheral tissues, leading to decreased synthesis of prostaglandins that mediate inflammation, pain and fever. By limiting prostaglandin production at the site of application, the drug provides localized anti‑inflammatory and analgesic effects without significant systemic exposure.

Topical etofenamate is generally well tolerated, but local and systemic reactions can occur.

Common Side Effects

• Skin irritation: mild redness or itching at the application site.
• Burning sensation: transient warmth or tingling after application.
• Dryness: localized dryness of the treated skin.
• Pruritus: occasional itching.
• Erythema: mild reddening of the skin.
• Contact dermatitis: allergic skin reaction in sensitive individuals.

Serious or Rare Side Effects

• Severe allergic reaction: swelling, hives or difficulty breathing.
• Systemic NSAID effects: gastrointestinal upset or ulceration if absorbed in large amounts.
• Renal impairment: reduced kidney function in susceptible patients.
• Hepatotoxicity: liver enzyme elevation in rare cases.
• Photosensitivity: heightened skin reaction to sunlight.
• Stevens‑Johnson syndrome: rare severe skin disorder.

• When using Melferut, consider the following safety measures.
• Avoid use on broken or infected skin: may increase systemic absorption.
• Limit application area: do not exceed the recommended surface area.
• Do not combine with other topical NSAIDs: risk of additive irritation.
• Monitor for signs of allergic reaction: discontinue if severe rash develops.
• Pregnancy and lactation: consult a healthcare professional before use.
• Store below 25°C: keep in the original container, protect from moisture and heat.

Topical etofenamate can interact with systemic and topical agents.

Major Interactions (Avoid)

• Oral anticoagulants (e.g., warfarin): increased bleeding risk.
• Systemic NSAIDs: additive gastrointestinal and renal effects.
• Corticosteroids: heightened risk of skin thinning.

Moderate Interactions (Monitor Closely)

• Alcohol: may exacerbate gastrointestinal irritation.
• Other topical medications: potential for reduced efficacy or irritation.
• Diuretics: monitor renal function if systemic absorption is significant.