Product image of Melhoral (Acetylsalicylic Acid, Caffeine) supplied by GNH India

Melhoral

Active Ingredient:
Acetylsalicylic Acid, Caffeine
Origin:
EU

Melhoral (Acetylsalicylic Acid, Caffeine)

Acetylsalicylic acid, the active ingredient in Melhoral, is an analgesic (NSAID) combination presented as an oral tablet for oral use in the European market. It relieves mild to moderate pain, reduces fever, and is commonly used for headache relief in adults.

GNH India supplies Melhoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable global distribution for healthcare providers. The company offers both bulk and unit‑dose packaging options to meet diverse procurement needs.

Manufacturer / TM Owner

Uriach Lusa S.A.

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Indications & Clinical Uses

Melhoral, a combination analgesic containing acetylsalicylic acid and caffeine, is used to manage pain and fever through inhibition of prostaglandin synthesis and central nervous system stimulation.

  • Headache: provides rapid relief by reducing inflammation and enhancing analgesic effect, useful for tension‑type and occasional migraine attacks.
  • Fever: lowers elevated body temperature by blocking prostaglandin‑mediated thermoregulation in the hypothalamus.
  • Mild to moderate pain: alleviates discomfort from dental, musculoskeletal or postoperative sources through combined anti‑inflammatory and stimulant actions.

How It Works

  • Acetylsalicylic acid irreversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation, pain and fever. Caffeine acts as a non‑selective adenosine receptor antagonist, increasing central nervous system activity and enhancing the analgesic effect of aspirin by promoting absorption and counteracting drowsiness. The combined action results in synergistic relief of pain and pyrexia.

Side Effects

Adverse reactions to Melhoral may vary in frequency and severity.

Common Side Effects

  • Nausea: mild stomach upset.
  • Gastric discomfort: irritation of the stomach lining.
  • Headache: paradoxical headache in some users.
  • Insomnia: difficulty sleeping due to caffeine.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: serious bleeding or ulceration.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Renal impairment: reduced kidney function with prolonged use.

Precautions & Warnings

Before using Melhoral, consider the following precautions to minimize risks.

  • Contraindication: avoid in individuals with known hypersensitivity to aspirin or caffeine.
  • Bleeding risk: use with caution in patients with peptic ulcer disease or anticoagulant therapy.
  • Asthma: may exacerbate aspirin‑induced asthma; monitor respiratory symptoms.
  • Pregnancy: safety not established; consult healthcare professional before use during pregnancy.
  • Children: not recommended for children under 12 years due to risk of Reye’s syndrome.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Melhoral can interact with several medicines; awareness of these interactions helps ensure safe use.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs (e.g., ibuprofen): additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding potential.
  • Corticosteroids: enhanced risk of gastric ulceration.

Moderate Interactions (Monitor Closely)

  • Diuretics: may reduce diuretic efficacy.
  • Antihypertensives: caffeine can diminish blood pressure‑lowering effect.
  • Lithium: caffeine may increase lithium serum levels.
  • Methotrexate: aspirin can reduce renal clearance, raising toxicity.

Frequently Asked Questions

Melhoral is an over‑the‑counter combination of acetylsalicylic acid and caffeine that is used to relieve mild to moderate pain, reduce fever, and treat common headaches in adults. It provides a rapid analgesic effect by targeting inflammation and stimulating the central nervous system.

Acetylsalicylic acid irreversibly blocks cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which stops the formation of prostaglandins that mediate pain, inflammation, and fever. By lowering prostaglandin levels, it reduces the body’s inflammatory response and helps lower elevated temperature.

The appropriate dose of Melhoral is determined by a qualified healthcare professional based on the individual’s condition, age, and medical history. Patients should follow the prescriber’s instructions and the product label, and should not exceed the recommended amount without medical advice.

Safety of Melhoral in pregnancy and lactation has not been established. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their physician before using the product, as alternative therapies may be preferred.

To order Melhoral, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with plain aspirin, Melhoral adds caffeine, which can enhance pain relief and reduce drowsiness. Unlike paracetamol, it has anti‑inflammatory activity through cyclooxygenase inhibition. The caffeine component may increase the risk of insomnia or gastrointestinal irritation, so patient tolerance and comorbidities should guide selection.

Melhoral tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure the packaging remains tightly closed to maintain product stability throughout its shelf life.

Melhoral is taken orally. The tablet should be swallowed whole with a full glass of water, preferably after a meal to lessen stomach irritation. Patients should not crush or chew the tablet unless directed by a healthcare professional.

The most serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, and potential renal impairment with prolonged use. Patients experiencing unusual bruising, black stools, rash, swelling, or sudden loss of kidney function should seek immediate medical attention.

Individuals with a known allergy to aspirin, other NSAIDs, or caffeine should avoid Melhoral. It is also contraindicated in patients with active peptic ulcer disease, severe liver or kidney disease, uncontrolled asthma triggered by aspirin, and children under 12 years of age due to the risk of Reye’s syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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