Product image of Meliane (Ethinylestradiol, Gestodene) supplied by GNH India

Meliane

Active Ingredient:
Ethinylestradiol, Gestodene
Origin:
EU

Meliane (Ethinylestradiol, Gestodene)

Ethinylestradiol and Gestodene, the active ingredients in Meliane, are a combined oral contraceptive presented as an oral tablet for oral use. It prevents unintended pregnancy in women of reproductive age by inhibiting ovulation and altering cervical mucus and endometrial lining.

GNH India supplies Meliane as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Bayer Ag

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Indications & Clinical Uses

  • Meliane, a combined oral contraceptive, is used to prevent pregnancy and manage hormone‑related menstrual conditions.
  • Contraception: Prevents unintended pregnancy in women of childbearing potential when taken daily.
  • Menstrual cycle regulation: Helps achieve more regular and predictable menstrual bleeding patterns.
  • Acne management: Reduces androgen‑driven acne in some women as an additional benefit of hormonal regulation.

How It Works

  • Ethinylestradiol, a synthetic estrogen, and gestodene, a third‑generation progestogen, bind to estrogen and progesterone receptors, respectively, suppressing the hypothalamic‑pituitary‑ovarian axis. This reduces luteinizing hormone and follicle‑stimulating hormone secretion, preventing follicular development and ovulation. The progestogenic component also thickens cervical mucus and induces endometrial changes that are unfavorable for sperm penetration and implantation.

Side Effects

Meliane may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Irregular vaginal bleeding

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism
  • Hepatic adenoma or benign liver tumor
  • Severe allergic reaction (anaphylaxis)

Precautions & Warnings

Before prescribing Meliane, consider the following precautions.

  • Smoking: Women who smoke and are over 35 years should avoid use due to increased cardiovascular risk.
  • Cardiovascular disease: Do not use in patients with a history of myocardial infarction, stroke, or uncontrolled hypertension.
  • Liver disease: Use with caution in patients with active liver disease or hepatic impairment.
  • Pregnancy: Contraindicated in pregnancy; discontinue immediately if pregnancy occurs.
  • Store at ambient temperature: Keep below 25 °C, in the original packaging, protected from moisture and light.

Avoid Interactions

Meliane can interact with several medicines; review patient medication lists carefully.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): May reduce efficacy of the oral contraceptive, increasing risk of pregnancy.
  • Enzyme inducers (e.g., rifampicin, carbamazepine, phenytoin): Significantly lower plasma levels of ethinylestradiol and gestodene, compromising contraceptive effect.

Moderate Interactions (Monitor Closely)

  • Antiretrovirals (e.g., protease inhibitors): May increase hormone concentrations, requiring monitoring for side effects.
  • Antifungals (e.g., ketoconazole): Can raise estrogen levels, potentially enhancing adverse effects.
  • Herbal supplements (e.g., St. John’s Wort): May modestly decrease contraceptive efficacy; advise consistent use of backup methods.

Frequently Asked Questions

Meliane is a combined oral contraceptive containing ethinylestradiol and gestodene. It is prescribed to prevent unintended pregnancy in women of reproductive age and can also help regulate menstrual cycles and improve hormone‑related acne when used as directed by a healthcare professional.

Ethinylestradiol mimics natural estrogen, while gestodene acts as a progestogen. Together they suppress the hypothalamic‑pituitary‑ovarian axis, lowering luteinizing hormone and follicle‑stimulating hormone levels, which prevents ovulation. The progestogen also thickens cervical mucus and alters the endometrium, creating an environment that hinders fertilisation and implantation.

The specific dosing regimen for Meliane is determined by the prescribing clinician. Typically, the medication is taken as one oral tablet each day at the same time, but the exact schedule and any missed‑dose instructions should be confirmed with the prescriber.

Meliane is contraindicated in pregnancy (pregnancy category X) and must be stopped immediately if pregnancy is confirmed. It is generally not recommended during breastfeeding because hormonal contraceptives can affect milk production and infant exposure; alternative methods should be discussed with a healthcare provider.

To order Meliane, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Meliane contains a third‑generation progestogen (gestodene) combined with ethinylestradiol, offering a low‑dose hormonal profile that may reduce androgenic side effects such as acne. Compared with older formulations, it provides similar contraceptive efficacy while potentially improving cycle control, but individual response and risk profiles should be evaluated by a clinician.

Meliane tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct light, and ensure they are out of reach of children. Do not store in bathrooms or other humid environments.

Meliane is taken orally as a single tablet each day, preferably at the same time each day to maintain steady hormone levels. The tablet should be swallowed whole with water and not chewed or broken. Consistent daily intake is essential for optimal contraceptive effectiveness.

Serious risks include venous thromboembolism (deep‑vein thrombosis or pulmonary embolism), arterial events such as stroke or myocardial infarction, and rare hepatic tumors. Women should seek immediate medical attention if they experience unexplained leg pain, shortness of breath, severe headache, visual changes, or abdominal pain.

Meliane should not be used by women who are pregnant, have a known hypersensitivity to any component, have a history of thromboembolic disorders, uncontrolled hypertension, certain cardiovascular diseases, active liver disease, or who smoke heavily and are over 35 years of age. A thorough medical assessment is required before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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