Product image of Meliane (Ethinylestradiol, Gestodene) supplied by GNH India

Meliane

Active Ingredient:
Ethinylestradiol, Gestodene
Origin:
EU

Meliane (Ethinylestradiol, Gestodene)

Ethinylestradiol, the active ingredient in Meliane, is a combined oral contraceptive presented as a tablet for oral use. It is used to prevent pregnancy in women of reproductive age by regulating hormonal cycles.
GNH India supplies Meliane as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Sa Nv

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Indications & Clinical Uses

  • Meliane, a combined oral contraceptive, is used to prevent pregnancy by modulating the hormonal axis.
  • Contraception: prevents ovulation and pregnancy when taken as prescribed.
  • Acne treatment: reduces androgen‑driven skin lesions in women.
  • Dysmenorrhea management: alleviates painful menstrual cramps and regulates bleeding patterns.

How It Works

  • Ethinylestradiol and gestodene act on the hypothalamic‑pituitary‑ovarian axis. Ethinylestradiol provides estrogenic activity while gestodene supplies progestogenic activity, together suppressing the release of luteinising hormone (LH) and follicle‑stimulating hormone (FSH). This inhibition prevents follicular development and ovulation, while also thickening cervical mucus and altering the endometrial lining to reduce the likelihood of implantation.

Side Effects

Common Side Effects

  • Nausea or upset stomach
  • Breast tenderness or enlargement
  • Headache or migraine
  • Weight gain or fluid retention
  • Mood changes or irritability
  • Breakthrough or spotting bleeding

Serious or Rare Side Effects

  • Venous thromboembolism (deep‑vein thrombosis, pulmonary embolism)
  • Arterial thrombosis (stroke, myocardial infarction)
  • Severe hypertension or hypertensive crisis
  • Liver adenoma or benign hepatic tumor
  • Gallbladder disease (cholestasis, gallstones)
  • Anaphylaxis or severe allergic reaction

Precautions & Warnings

Before initiating therapy, consider individual risk factors and contraindications.

  • Thrombotic risk assessment: evaluate personal or family history of clotting disorders.
  • Smoking restriction: avoid use in women who smoke more than 15 cigarettes per day.
  • Liver disease review: contraindicated in active or severe hepatic impairment.
  • Blood pressure monitoring: check for hypertension before and during treatment.
  • Missed pill guidance: provide clear instructions on how to manage missed doses.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Major Interactions (Avoid)

  • Enzyme inducers (e.g., rifampin, carbamazepine): reduce contraceptive effectiveness.
  • Antiretroviral efavirenz: may lower hormone levels and increase pregnancy risk.
  • St. John’s wort: accelerates metabolism of estrogen and progestin components.
  • Certain antifungals (e.g., griseofulvin): decrease plasma concentrations of active ingredients.
  • Anticonvulsants (e.g., phenobarbital): may compromise contraceptive reliability.

Moderate Interactions (Monitor Closely)

  • SSRIs (e.g., fluoxetine): may increase risk of bleeding or affect hormone levels.
  • Antihypertensives (e.g., ACE inhibitors): monitor blood pressure for additive effects.
  • Diuretics: may alter electrolyte balance when combined with hormonal therapy.
  • Herbal supplements (e.g., ginkgo biloba): potential for increased bleeding risk.
  • Antibiotics (e.g., tetracycline): generally minimal effect but advise vigilance.

Frequently Asked Questions

Meliane is a combined oral contraceptive containing ethinylestradiol and gestodene. It is prescribed primarily to prevent pregnancy by inhibiting ovulation, and it can also be used to manage acne and dysmenorrhea in women who require hormonal regulation.

Ethinylestradiol provides estrogenic activity that, together with gestodene’s progestogenic effect, suppresses the hypothalamic‑pituitary release of luteinising hormone and follicle‑stimulating hormone. This suppression blocks follicular development, prevents ovulation, and creates cervical mucus and endometrial changes that reduce the chance of fertilisation and implantation.

The dosing regimen for Meliane is determined by the prescribing healthcare professional. Typically, it is taken as a daily tablet according to a fixed schedule, but the exact number of tablets and cycle length should follow the prescriber’s instructions and the product’s labeling.

Meliane is classified as pregnancy category X, meaning it must not be used during pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as hormonal components may pass into breast milk and affect the infant. Women should discontinue use if they become pregnant.

To request Meliane, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Meliane contains ethinylestradiol and gestodene, a low‑dose progestin that offers a favorable bleeding profile and lower androgenic activity compared with some older formulations. Compared with alternatives that use higher‑dose estrogen or different progestins, Meliane may provide similar contraceptive efficacy with potentially fewer estrogen‑related side effects.

Meliane tablets should be stored at ambient temperature, below 25 °C (77 °F). Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Meliane is taken orally, usually once daily at the same time each day. The tablets are swallowed with water and should be started according to the prescriber’s schedule, often on the first day of the menstrual period or as directed in the prescribing information.

The most serious risks include venous and arterial thromboembolic events such as deep‑vein thrombosis, pulmonary embolism, stroke, and myocardial infarction. Additional severe concerns are hypertension, liver tumors, gallbladder disease, and rare allergic reactions. Patients should be educated on warning signs and seek immediate medical attention if they occur.

Meliane is contraindicated in women with a history of thromboembolic disorders, uncontrolled hypertension, active or severe liver disease, known or suspected breast cancer, and in smokers over 15 cigarettes per day. It should also be avoided during pregnancy and in individuals with known hypersensitivity to any component of the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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