Product image of Melkart Duo (Metformin Hydrochloride, Vildagliptin) supplied by GNH India

Melkart Duo

Active Ingredient:
Metformin Hydrochloride, Vildagliptin
Origin:
EU

Melkart Duo (Metformin Hydrochloride, Vildagliptin)

Metformin Hydrochloride and Vildagliptin, the active ingredients in Melkart Duo, are a Biguanide and DPP‑4 inhibitor presented as an oral tablet for oral use. They are indicated for the management of type 2 diabetes mellitus in adult patients, helping to control blood glucose levels.

GNH India supplies Melkart Duo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Melkart Duo combines metformin and vildagliptin to target hyperglycaemia in type 2 diabetes mellitus.

  • Type 2 diabetes mellitus: improves glycaemic control when used with diet and exercise.
  • Inadequate control on metformin alone: provides additional DPP‑4 inhibition to achieve target glucose levels.
  • Adjunct therapy: can be added to other antidiabetic agents as part of a comprehensive treatment regimen.

How It Works

  • Metformin reduces hepatic glucose production and enhances peripheral insulin sensitivity, while vildagliptin inhibits the enzyme dipeptidyl peptidase‑4 (DPP‑4), leading to increased levels of endogenous incretins (GLP‑1 and GIP). The elevated incretins promote glucose‑dependent insulin secretion and suppress glucagon release, together producing improved glycaemic control.

Side Effects

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or diarrhoea.
  • Headache: mild to moderate intensity.
  • Upper respiratory tract infection symptoms.
  • Dizziness or light‑headedness.
  • Mild hypoglycaemia when combined with other glucose‑lowering agents.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening metabolic complication.
  • Pancreatitis: severe abdominal pain with elevated enzymes.
  • Severe allergic reactions: rash, angio‑edema, or anaphylaxis.
  • Hepatic dysfunction: jaundice or abnormal liver tests.
  • Persistent vomiting leading to dehydration.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Renal function: assess eGFR; avoid in severe renal impairment.
  • Hepatic disease: monitor liver enzymes and avoid in severe hepatic dysfunction.
  • Lactic acidosis risk: discontinue if patient experiences unexplained acidosis symptoms.
  • Vitamin B12 monitoring: long‑term metformin use may reduce B12 levels.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and keep in original packaging.

Avoid Interactions

Metformin and vildagliptin may interact with several medicines.

Major Interactions (Avoid)

  • Iodinated contrast media: can precipitate acute renal failure and increase metformin accumulation.
  • Cimetidine: may raise metformin plasma concentrations, increasing risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal clearance of metformin.
  • ACE inhibitors or ARBs: monitor renal function and potassium levels.
  • Alcohol: potentiates risk of lactic acidosis.
  • Sulfonylureas or insulin: increased risk of hypoglycaemia.
  • Strong CYP3A4 inhibitors: may elevate vildagliptin levels.

Frequently Asked Questions

Melkart Duo is a fixed‑dose oral tablet that combines metformin hydrochloride and vildagliptin. It is prescribed to improve blood‑glucose control in adult patients with type 2 diabetes mellitus, typically as part of a broader regimen that includes diet, exercise and possibly other antidiabetic agents.

Metformin hydrochloride belongs to the biguanide class. It lowers blood glucose primarily by decreasing hepatic gluconeogenesis, reducing intestinal glucose absorption, and enhancing peripheral insulin sensitivity, which together help lower fasting and post‑prandial glucose levels.

The specific dose of Melkart Duo is determined by the prescribing healthcare professional based on the individual’s clinical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of Melkart Duo in pregnancy and lactation has not been established. Healthcare providers must weigh the potential benefits against possible risks and consider alternative treatments when treating pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Melkart Duo offers a dual mechanism—biguanide action of metformin plus DPP‑4 inhibition by vildagliptin—providing complementary glucose‑lowering effects. Compared with metformin alone, the combination can achieve better glycaemic control, while differing from sulfonylureas by having a lower intrinsic risk of hypoglycaemia.

Melkart Duo tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original blister pack, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Melkart Duo is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless otherwise directed by a healthcare professional.

The most serious risks include lactic acidosis, which is rare but potentially fatal, and pancreatitis. Patients should seek immediate medical attention if they experience severe abdominal pain, unexplained muscle weakness, rapid breathing, or signs of an allergic reaction.

Melkart Duo is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), known hypersensitivity to metformin, vildagliptin or any excipients, and in those with a history of lactic acidosis. Caution is also advised for individuals with significant hepatic disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Metformin Hydrochloride, Vildagliptin

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT