Product image of Melleva (Ethinylestradiol, Levonorgestrel) supplied by GNH India

Melleva

Active Ingredient:
Ethinylestradiol, Levonorgestrel
Origin:
EU

Melleva (Ethinylestradiol, Levonorgestrel)

Ethinylestradiol and Levonorgestrel, the active ingredients in Melleva, are a combined oral contraceptive presented as an oral tablet for oral use. They work to prevent pregnancy in women of reproductive age by inhibiting ovulation, altering cervical mucus, and inducing endometrial changes.

GNH India supplies Melleva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global logistics for regulated medicines, ensuring timely delivery and compliance with local regulatory requirements.

Manufacturer / TM Owner

Exeltis Healthcare S.L

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Indications & Clinical Uses

Melleva, a combined oral contraceptive, is indicated for hormonal contraception to prevent pregnancy and related menstrual conditions.

  • Contraception: prevents pregnancy in women of reproductive age.
  • Menstrual cycle regulation: helps establish regular menstrual cycles and reduces heavy bleeding.
  • Acne treatment: decreases acne lesions by reducing androgenic activity in the skin.

How It Works

  • Ethinylestradiol acts as a synthetic estrogen, binding to estrogen receptors and providing negative feedback to the hypothalamic‑pituitary axis, while levonorgestrel is a synthetic progestogen that binds progesterone receptors, suppressing luteinizing hormone surge and preventing ovulation. The progestin also thickens cervical mucus and induces endometrial changes that are unfavorable for implantation. Together, these actions maintain a hormonal environment that blocks the sequence required for fertilization and implantation.

Side Effects

Melleva may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: swelling or discomfort in the breasts.
  • Spotting between periods: light vaginal bleeding.

Serious or Rare Side Effects

  • Deep vein thrombosis: blood clot formation in deep veins.
  • Pulmonary embolism: clot traveling to lungs, potentially life‑threatening.
  • Hepatic adenoma: benign liver tumor.

Precautions & Warnings

Before prescribing Melleva, clinicians should consider several safety measures.

  • Assess thromboembolic risk: evaluate personal and family history of clotting disorders.
  • Screen for hypertension: measure blood pressure before initiating therapy.
  • Advise smoking cessation: avoid use in women over 35 who smoke.
  • Monitor liver function: use with caution in hepatic impairment.
  • Review concomitant medications: check for drugs that may reduce effectiveness.
  • Store at ambient temperature: keep tablets in original packaging, protect from moisture and light.

Avoid Interactions

Melleva can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): may markedly reduce contraceptive efficacy.
  • Antiretroviral protease inhibitors (e.g., ritonavir): can increase hormone levels and risk of side effects.
  • St. John’s wort: herbal inducer that may decrease plasma concentrations of the hormones.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline, metronidazole): may slightly lower effectiveness.
  • Antifungal agents (e.g., fluconazole): can increase hormone exposure.
  • Diuretics (e.g., spironolactone): may exacerbate fluid retention and blood pressure changes.

Frequently Asked Questions

Melleva is a prescription combined oral contraceptive containing ethinylestradiol and levonorgestrel. It is primarily used to prevent pregnancy in women of reproductive age and may also be prescribed to help regulate menstrual cycles or treat acne associated with hormonal imbalance.

Ethinylestradiol provides estrogenic activity that suppresses the release of follicle‑stimulating hormone, while levonorgestrel supplies progestogenic activity that blocks the luteinizing hormone surge, preventing ovulation. The progestin also thickens cervical mucus and alters the endometrium, creating conditions unfavorable for fertilisation and implantation.

The dosing regimen for Melleva is determined by a qualified prescriber. Typically, the medication is taken as one tablet daily at the same time each day, but the exact schedule and duration should follow the healthcare professional’s instructions.

Melleva is intended for use only when pregnancy is not desired; it is not a treatment for an existing pregnancy. Women who become pregnant should discontinue the product and consult their physician. Breastfeeding mothers should discuss potential risks and benefits with a healthcare provider before using the medication.

To order Melleva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details and assists with any necessary import documentation.

Melleva contains the standard dose combination of ethinylestradiol and levonorgestrel, which is comparable to many other combined oral contraceptives on the market. Its efficacy, safety profile and side‑effect spectrum are similar to other EE/LNG products, with differences mainly in tablet formulation, packaging and regulatory approvals.

Melleva tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect the product from moisture, direct sunlight and excessive heat to maintain potency throughout its shelf life.

Melleva is taken orally, usually once daily, at the same time each day. The tablet is swallowed whole with water and can be taken with or without food. Consistent daily intake is important to maintain contraceptive effectiveness.

Serious but rare risks include venous thromboembolism, pulmonary embolism, stroke, hepatic adenoma and severe allergic reactions such as anaphylaxis. Women with a history of clotting disorders, smoking over age 35, uncontrolled hypertension or certain liver conditions should discuss these risks with their healthcare provider.

Melleva is contraindicated in women who are pregnant, have known or suspected breast cancer, have a history of thromboembolic disease, uncontrolled hypertension, severe liver disease, or are smokers over 35 years of age. It should also be avoided in individuals with known hypersensitivity to any component of the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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