Product image of Mellozzan (Melatonin) supplied by GNH India

Mellozzan

Active Ingredient:
Melatonin
Origin:
EU

Mellozzan (Melatonin)

Melatonin, the active ingredient in Mellozzan, is a melatonin receptor agonist presented as an oral tablet for oral use. It helps regulate the sleep‑wake cycle and is used to promote sleep onset in adults with sleep disturbances, and is commonly employed in the management of transient insomnia, jet lag, and shift‑work related sleep disruption.

GNH India supplies Mellozzan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide across multiple regulatory jurisdictions and health‑care institutions, ensuring consistent quality.

Manufacturer / TM Owner

Eql Pharma Ab

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Indications & Clinical Uses

  • Mellozzan (melatonin) acts on the melatonin receptor pathway to support normal sleep regulation.
  • Insomnia: reduces sleep onset latency and improves total sleep time in adults with transient insomnia.
  • Jet lag: facilitates adjustment of the circadian rhythm after rapid time‑zone travel.
  • Shift work disorder: helps align sleep patterns for individuals working non‑standard hours.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus of the hypothalamus, mimicking the endogenous hormone released during darkness. Activation of these G‑protein‑coupled receptors modulates intracellular cyclic AMP levels, leading to phase‑shifting of the circadian clock and promotion of sleep initiation. By restoring the normal melatonin signal, the drug helps synchronize the body’s internal rhythm with the external light‑dark cycle.

Side Effects

Mellozzan may be associated with several adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate headache reported.
  • Dizziness: occasional sensation of light‑headedness.
  • Daytime sleepiness: residual drowsiness after dosing.
  • Nausea: mild gastrointestinal upset.
  • Irritability: transient mood changes.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Severe depression: worsening mood or depressive symptoms.
  • Seizures: rare occurrence of convulsive episodes.

Precautions & Warnings

Before using Mellozzan, consider the following precautions to ensure safe and effective use.

  • Assess indication: confirm that the sleep disturbance is appropriate for melatonin therapy.
  • Review medications: evaluate potential interactions with anticoagulants, CNS depressants, or immunosuppressants.
  • Monitor drowsiness: advise patients to avoid operating machinery or driving if residual sleepiness occurs.
  • Use in special populations: exercise caution in children, elderly, and pregnant or breastfeeding individuals.
  • Discontinue if allergic: stop the product immediately if signs of hypersensitivity develop.
  • Store at ambient temperature: keep below 25 °C in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Melatonin can interact with other medicines; the following interactions are recognized.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): melatonin may increase bleeding risk; concurrent use should be avoided.
  • Central nervous system depressants (e.g., benzodiazepines, barbiturates): combined use can enhance sedation and impair psychomotor performance.

Moderate Interactions (Monitor Closely)

  • Immunosuppressants (e.g., cyclosporine): melatonin may alter immune response; monitor therapeutic levels.
  • Antidiabetic agents: melatonin can affect glucose metabolism; check blood sugar regularly.
  • Oral contraceptives: melatonin may increase plasma concentrations; observe for hormonal side effects.

Frequently Asked Questions

Mellozzan contains melatonin, a hormone that helps regulate the sleep‑wake cycle. It is used to support the onset of sleep in adults experiencing transient insomnia, to alleviate symptoms of jet lag after rapid travel across time zones, and to improve sleep quality for people who work irregular or night shifts.

Melatonin acts as an agonist at the MT1 and MT2 receptors located in the suprachiasmatic nucleus of the hypothalamus. By binding these receptors, it mimics the natural nighttime rise in melatonin, signaling the body that it is time to sleep and thereby helping to synchronize the internal circadian rhythm with external light‑dark cues.

The appropriate dose of Mellozzan is determined by a qualified healthcare professional based on the individual’s age, the specific sleep condition being treated, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for melatonin use in pregnancy and lactation are limited. Healthcare providers generally recommend caution and may advise against routine use unless the potential benefit outweighs any possible risk. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their physician.

To request Mellozzan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any required temperature control) and assistance with import documentation.

Unlike benzodiazepines or antihistamine sleep aids, melatonin works by restoring the body’s natural hormonal signal rather than depressing central nervous system activity. This generally results in fewer next‑day residual effects and a lower risk of dependence, although individual response can vary and some patients may still experience mild drowsiness.

Mellozzan should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, heat and direct sunlight, and keep out of reach of children. No refrigeration is required for this oral formulation.

Mellozzan is taken orally, usually with a glass of water. For best effect, it is commonly recommended to take the tablet 30‑60 minutes before the desired bedtime, following the dosing schedule prescribed by the treating clinician.

Although rare, serious adverse reactions can include severe allergic responses such as rash, swelling, or anaphylaxis, as well as worsening depression or rare seizure activity. Patients should seek immediate medical attention if they experience any signs of a severe reaction.

Mellozzan should be avoided by individuals with known hypersensitivity to melatonin or any excipients in the tablet. Caution is also advised for patients with uncontrolled epilepsy, severe depression, or those taking medications that may interact significantly, such as anticoagulants or potent CNS depressants. A healthcare professional should evaluate suitability before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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