Product image of Melneurin (Melperone Hydrochloride) supplied by GNH India

Melneurin

Active Ingredient:
Melperone Hydrochloride
Origin:
EU

Melneurin (Melperone Hydrochloride)

Melperone Hydrochloride, the active ingredient in Melneurin, is a typical antipsychotic presented as an oral tablet for oral use. It is employed in the management of schizophrenia and acute psychotic episodes in adult patients and is prescribed by qualified healthcare professionals under medical supervision.

GNH India supplies Melneurin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support import and distribution across multiple regions.

Manufacturer / TM Owner

Hexal Ag

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Indications & Clinical Uses

Melneurin (melperone hydrochloride) is used in the treatment of psychotic disorders that involve dopaminergic dysregulation.

  • Schizophrenia: alleviates positive and negative symptoms, improving overall functioning.
  • Acute psychotic episodes: reduces agitation and hallucinations, facilitating stabilization.
  • Psychotic symptoms associated with severe mental illness: helps control persistent delusions and thought disorder when other agents are unsuitable.

How It Works

  • Melperone hydrochloride acts primarily as a dopamine D2 receptor antagonist. By blocking D2 receptors in the mesolimbic pathway, it reduces dopaminergic neurotransmission that underlies psychotic manifestations. The drug also exhibits moderate antagonism at serotonin 5‑HT2 receptors, contributing to its overall antipsychotic profile.

Side Effects

Melneurin may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Sedation or drowsiness
  • Dry mouth
  • Constipation
  • Orthostatic hypotension
  • Dizziness
  • Weight gain

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome
  • Tardive dyskinesia
  • Seizures
  • Agranulocytosis
  • Severe hypotension
  • Myocarditis

Precautions & Warnings

When prescribing Melneurin, clinicians should observe several safety measures.

  • Monitor blood pressure: watch for orthostatic hypotension especially during initiation.
  • Assess for extrapyramidal symptoms: observe for tremor, rigidity, or akathisia.
  • Evaluate metabolic parameters: check weight, glucose, and lipid profile periodically.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Avoid abrupt discontinuation: taper under medical supervision to reduce withdrawal risk.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Melneurin can interact with other medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase melperone plasma levels.
  • Other dopamine antagonists (e.g., haloperidol): additive risk of extrapyramidal effects.
  • QT‑prolonging agents (e.g., quinidine, sotalol): heightened risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Anticholinergic drugs (e.g., benztropine): may mask extrapyramidal symptoms.
  • Central nervous system depressants (e.g., benzodiazepines, alcohol): enhanced sedation.
  • Antihypertensive agents: possible additive hypotensive effect.

Frequently Asked Questions

Melneurin contains melperone hydrochloride and is indicated for the treatment of schizophrenia and acute psychotic episodes. It helps reduce hallucinations, delusions, and agitation associated with these conditions, supporting stabilization of mental status in adult patients.

Melperone hydrochloride works by blocking dopamine D2 receptors in the brain, which diminishes excessive dopaminergic activity that contributes to psychotic symptoms. It also moderately antagonises serotonin 5‑HT2 receptors, adding to its antipsychotic effect.

The exact dose of Melneurin is determined by the prescribing clinician based on the patient’s clinical condition, response, and tolerability. Physicians typically start with a low dose and adjust gradually, following local prescribing guidelines.

Safety data for melperone hydrochloride in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Melneurin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Melneurin (melperone) belongs to the butyrophenone class, similar to haloperidol, but generally shows a lower incidence of extrapyramidal side effects. Its sedative profile may be more pronounced, and it offers an alternative when patients experience intolerance to other typical agents.

Melneurin should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain stability and potency.

Melneurin is administered orally. The tablet should be swallowed whole with a glass of water, preferably with or without food as directed by the prescriber. Do not crush or chew the tablet unless specifically instructed.

Serious risks include neuroleptic malignant syndrome, tardive dyskinesia, severe hypotension, seizures, agranulocytosis, and myocarditis. Patients should be monitored closely for signs such as high fever, muscle rigidity, sudden drop in blood pressure, or abnormal movements, and seek immediate medical attention if they occur.

Melneurin is contraindicated in individuals with known hypersensitivity to melperone or any excipients, those with severe central nervous system depression, and patients with a history of malignant hyperthermia. Caution is also advised for patients with significant cardiac, hepatic, or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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