Product image of Melnite (Melatonin) supplied by GNH India

Melnite

Active Ingredient:
Melatonin
Origin:
EU

Melnite (Melatonin)

Melatonin, the active ingredient in Melnite, is a melatonin receptor agonist presented as an oral formulation for oral use. It mimics the endogenous hormone that signals darkness to the brain, thereby helping to synchronize circadian rhythms and improve sleep onset, duration, and quality in adults experiencing insomnia or jet‑lag related disturbances.

GNH India supplies Melnite as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to Good Distribution Practice and provides regulatory‑compliant shipments to a global network of healthcare providers.

Manufacturer / TM Owner

Pinewood Laboratories Limited

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Indications & Clinical Uses

  • Melnite (melatonin) acts on the melatonin receptor pathway to address disorders of the sleep‑wake cycle.
  • Insomnia: reduces sleep onset latency and improves total sleep time in adults.
  • Delayed sleep phase disorder: advances circadian timing to promote earlier sleep onset.
  • Jet lag: alleviates sleep disruption and daytime fatigue after rapid time‑zone travel.

How It Works

  • Melatonin exerts its effect by binding to MT1 and MT2 receptors located in the suprachiasmatic nucleus of the hypothalamus. Activation of these G‑protein‑coupled receptors modulates intracellular cyclic AMP levels, leading to phase‑shifting of the circadian clock and promotion of sleepiness during the biological night. The resulting synchronization of endogenous rhythms supports normal sleep architecture.

Side Effects

Oral melatonin may be associated with a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Drowsiness: feeling unusually sleepy during the day.
  • Headache: mild to moderate pain in the head.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: feeling of stomach upset.

Serious or Rare Side Effects

  • Allergic reaction: rash, swelling, or hives requiring medical attention.
  • Mood changes: depression, irritability, or anxiety that are severe.
  • Severe hypotension: marked drop in blood pressure leading to faintness.

Precautions & Warnings

  • When considering melatonin therapy, several safety considerations should be reviewed.
  • Pregnancy: safety has not been established; use only if potential benefit justifies the risk.
  • Breastfeeding: unknown effects on infant; discuss with healthcare professional.
  • Concomitant CNS depressants: may enhance sedative effects, requiring monitoring.
  • Autoimmune disorders: melatonin can modulate immune function; observe for disease activity changes.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Melatonin can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): may reduce melatonin clearance.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): additive sedation.
  • Antidepressants (e.g., SSRIs): possible serotonin syndrome.
  • Oral contraceptives: may increase melatonin plasma levels.

Frequently Asked Questions

Melnite contains melatonin, a hormone that regulates the sleep‑wake cycle. It is used to help adults who have difficulty falling asleep, experience delayed sleep phase disorder, or suffer from jet lag after rapid travel across time zones.

Melatonin works by binding to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. This interaction signals darkness, helping to shift and synchronize the body’s internal clock, which promotes the onset of sleep and improves overall sleep quality.

The appropriate dose of melatonin is individualized by a healthcare professional based on the patient’s age, condition, and response. Prescribers typically start with a low dose and adjust as needed, following clinical guidelines.

Safety data for melatonin in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk, and this decision must be made in consultation with a qualified healthcare provider.

To order Melnite, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Melatonin differs from traditional hypnotics such as benzodiazepines or Z‑drugs because it acts on the body’s natural circadian system rather than directly depressing the central nervous system. This generally results in fewer next‑day sedation effects, but its efficacy is most pronounced for circadian‑related sleep disturbances.

Melnite should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Melnite is taken orally, usually with a glass of water. It is commonly taken 30‑60 minutes before the desired bedtime, but the exact timing and administration instructions should follow the prescribing clinician’s guidance.

Serious risks, though rare, include severe allergic reactions such as rash, swelling, or hives, and significant mood changes like depression or irritability. In rare cases, melatonin can cause marked drops in blood pressure, leading to faintness or dizziness.

Melatonin should be avoided by individuals with known hypersensitivity to melatonin or any excipients in the product. It is also contraindicated in patients taking certain anticoagulants or immunosuppressants without medical supervision, and caution is advised for those with uncontrolled autoimmune disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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