Product image of Melorem (Meloxicam) supplied by GNH India

Melorem

Active Ingredient:
Meloxicam
Origin:
EU

Melorem (Meloxicam)

Meloxicam, the active ingredient in Melorem, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for systemic use. It is indicated for the management of inflammatory joint conditions and acute pain in adult patients.
GNH India supplies Melorem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Remedica Ltd

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Indications & Clinical Uses

Meloxicam is employed to control inflammation and pain in several musculoskeletal disorders.

  • Rheumatoid arthritis: reduces joint swelling, pain and stiffness, helping maintain functional ability.
  • Osteoarthritis: alleviates chronic joint discomfort and improves mobility.
  • Ankylosing spondylitis: diminishes spinal inflammation and associated pain.
  • Acute pain: provides rapid relief of short‑term moderate pain from injury or surgery.

How It Works

  • Meloxicam selectively inhibits the cyclooxygenase‑2 (COX‑2) enzyme, which is responsible for converting arachidonic acid into prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin synthesis at sites of inflammation, the drug decreases vascular permeability, leukocyte infiltration, and nociceptor sensitisation, resulting in anti‑inflammatory and analgesic effects.

Side Effects

Meloxicam may cause a range of adverse reactions, most of which are dose‑related and reversible upon discontinuation.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Peripheral oedema: mild swelling of the lower limbs.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Renal impairment: reduced kidney function or acute renal failure.
  • Cardiovascular events: increased risk of myocardial infarction or stroke, especially with long‑term use.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal function: assess baseline kidney function and monitor periodically.
  • Hepatic health: evaluate liver enzymes prior to treatment and during prolonged use.
  • Cardiovascular risk: avoid in patients with established coronary artery disease unless benefits outweigh risks.
  • Concomitant NSAIDs or anticoagulants: use with caution to minimise bleeding risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Meloxicam can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • Lithium: elevated lithium serum concentrations.
  • Methotrexate: potential for enhanced toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: may exacerbate fluid retention and renal effects.
  • Selective serotonin reuptake inhibitors (SSRIs): increased risk of gastrointestinal bleeding.

Frequently Asked Questions

Melorem, containing meloxicam, is prescribed for inflammatory joint diseases such as rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, as well as for short‑term relief of moderate acute pain. It works by reducing inflammation and pain in the affected tissues.

Meloxicam selectively blocks the cyclooxygenase‑2 (COX‑2) enzyme, which is essential for the production of prostaglandins that cause inflammation, pain, and fever. By lowering prostaglandin levels at sites of inflammation, the drug provides anti‑inflammatory and analgesic effects while sparing COX‑1 activity that protects the stomach lining.

The appropriate dose of Melorem is determined by the prescribing healthcare professional based on the patient’s condition, severity, and individual response. Dosage adjustments may be required for renal or hepatic impairment, and the prescriber will provide specific instructions.

Safety of meloxicam in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Meloxicam offers a relatively selective COX‑2 inhibition, which may result in a lower incidence of gastrointestinal irritation compared with non‑selective NSAIDs such as ibuprofen or naproxen. However, cardiovascular and renal safety considerations remain similar across the class, and choice of therapy should be individualized.

Melorem should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure it is out of reach of children.

Melorem is taken orally, usually with a full glass of water. It may be taken with or without food, but if gastrointestinal upset occurs, taking it with meals can help minimise discomfort.

Serious risks include gastrointestinal ulceration or bleeding, severe liver injury, acute kidney failure, and an increased chance of cardiovascular events such as heart attack or stroke, especially with long‑term use or in patients with existing cardiovascular disease.

Melorem is contraindicated in patients with known hypersensitivity to meloxicam or other NSAIDs, those with active gastrointestinal bleeding or ulceration, and individuals with severe heart failure or uncontrolled hypertension. Patients with significant renal or hepatic impairment should also avoid use unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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