Product image of Meloxicam Ciclum (Meloxicam) supplied by GNH India

Meloxicam Ciclum

Active Ingredient:
Meloxicam
Origin:
EU

Meloxicam Ciclum (Meloxicam)

Meloxicam, the active ingredient in Meloxicam Ciclum, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It is indicated for the relief of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and other acute musculoskeletal conditions.

GNH India supplies Meloxicam Ciclum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Ciclum Farma Unipessoal Lda.

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Indications & Clinical Uses

Meloxicam acts on inflammatory pathways in musculoskeletal disorders, providing analgesic and anti‑inflammatory effects.

  • Osteoarthritis: reduces joint pain and swelling, improving mobility.
  • Rheumatoid arthritis: alleviates chronic inflammation and joint damage progression.
  • Ankylosing spondylitis: diminishes spinal pain and stiffness.
  • Acute pain: provides rapid relief of moderate to severe pain from injuries or postoperative states.

How It Works

  • Meloxicam selectively inhibits cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins that mediate inflammation, pain and fever. At higher doses, it also modestly inhibits COX‑1, contributing to its overall anti‑inflammatory profile. By reducing prostaglandin synthesis, meloxicam diminishes vascular permeability, leukocyte infiltration and nociceptor sensitization in affected tissues.

Side Effects

Meloxicam may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding
  • Cardiovascular thrombotic events (e.g., heart attack, stroke)
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Acute renal impairment or failure

Precautions & Warnings

Before initiating meloxicam therapy, consider the following precautions to minimize risk.

  • Cardiovascular risk assessment: evaluate history of heart disease or stroke before use.
  • Renal function monitoring: check kidney function periodically, especially in elderly patients.
  • Use lowest effective dose: prescribe the minimal dose needed for symptom control.
  • Pregnancy caution: avoid use in the third trimester and discuss risks with a healthcare provider.
  • Concomitant alcohol or NSAID use: limit to reduce gastrointestinal toxicity.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Meloxicam can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Warfarin: increased risk of bleeding.
  • Other NSAIDs (e.g., ibuprofen, diclofenac): heightened gastrointestinal toxicity.
  • High‑dose aspirin: additive antiplatelet effect raising bleeding risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors (e.g., lisinopril): may reduce antihypertensive effect and impair renal function.
  • Diuretics (e.g., furosemide): potential for decreased renal clearance.
  • Lithium: meloxicam may raise lithium serum concentrations, requiring monitoring.

Frequently Asked Questions

Meloxicam Ciclum is prescribed to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other acute musculoskeletal conditions. It belongs to the NSAID class and works by reducing inflammatory mediators in the body.

Meloxicam works by selectively inhibiting the cyclooxygenase‑2 (COX‑2) enzyme, which reduces the synthesis of prostaglandins—key compounds that cause inflammation, pain, and fever. At higher doses it may also affect COX‑1, contributing to its overall anti‑inflammatory effect.

The appropriate dose of meloxicam is determined by the prescribing healthcare professional based on the patient’s condition, severity of symptoms, age, renal function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Meloxicam is classified as Pregnancy Category C, meaning risk cannot be ruled out and it should be avoided, especially in the third trimester. Limited data are available for breastfeeding; therefore, use only if the potential benefit justifies the potential risk to the infant.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Meloxicam has a longer half‑life than ibuprofen, allowing once‑daily dosing for many patients. It is more selective for COX‑2 at standard doses, which may reduce gastrointestinal irritation compared with non‑selective NSAIDs, though the overall safety profile remains similar.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging to protect from moisture and light. Do not store in a refrigerator or freezer, and keep out of reach of children.

Meloxicam Ciclum is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can help reduce possible stomach upset. Follow the prescriber’s dosing schedule precisely.

Serious risks include gastrointestinal ulceration or bleeding, cardiovascular events such as heart attack or stroke, severe skin reactions like Stevens‑Johnson syndrome, and acute kidney injury. Patients should seek immediate medical attention if they notice signs such as black stools, chest pain, rash, or sudden swelling.

Meloxicam should be avoided by individuals with known hypersensitivity to meloxicam or other NSAIDs, those with active peptic ulcer disease, severe heart failure, uncontrolled hypertension, or significant renal impairment. It is also contraindicated in the third trimester of pregnancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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