Product image of Melus (Meloxicam) supplied by GNH India

Melus

Active Ingredient:
Meloxicam
Origin:
EU

Melus (Meloxicam)

Meloxicam, the active ingredient in Melus, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other musculoskeletal disorders.

GNH India supplies Melus as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medichrom A.E.

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Indications & Clinical Uses

Meloxicam is an NSAID used to manage inflammatory joint diseases and related pain.

  • Osteoarthritis: reduces joint pain and improves mobility.
  • Rheumatoid arthritis: alleviates inflammation and slows disease progression.
  • Ankylosing spondylitis: diminishes spinal stiffness and discomfort.
  • Acute pain: provides short‑term relief of moderate to severe pain.

How It Works

  • Meloxicam selectively inhibits cyclooxygenase‑2 (COX‑2) enzymes, with lesser effect on COX‑1, leading to decreased synthesis of prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels at sites of inflammation, it attenuates the inflammatory response while preserving gastric mucosal protection relative to non‑selective NSAIDs.

Side Effects

Adverse reactions may range from mild to serious and should be monitored during therapy.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Peripheral edema.
  • Skin rash or pruritus.
  • Elevated blood pressure.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Hepatic injury with elevated transaminases.
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome).
  • Renal impairment or failure.
  • Anaphylactic or severe hypersensitivity reactions.

Precautions & Warnings

Before initiating meloxicam, clinicians should consider patient‑specific risk factors and monitor therapy appropriately.

  • Gastrointestinal risk assessment: evaluate history of ulcer disease or bleeding.
  • Cardiovascular monitoring: watch for hypertension or thrombotic events.
  • Renal and hepatic function: check baseline labs and adjust if impairment exists.
  • Concomitant medications: avoid unnecessary NSAID combinations.
  • Hypersensitivity: discontinue if signs of severe allergy appear.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Meloxicam can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • ACE inhibitors or ARBs: may reduce renal perfusion.
  • Lithium: elevated serum lithium levels.
  • High‑dose aspirin: potentiates antiplatelet effect.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in antihypertensive efficacy.
  • Methotrexate: decreased clearance leading to toxicity.
  • Corticosteroids: heightened risk of gastrointestinal ulceration.
  • SSRIs: modest increase in bleeding tendency.
  • Antihypertensives: may blunt blood pressure control.

Frequently Asked Questions

Melus contains meloxicam, an NSAID indicated for the symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and for short‑term relief of moderate to severe pain associated with these musculoskeletal disorders.

Meloxicam selectively blocks the cyclooxygenase‑2 (COX‑2) enzyme, reducing the production of prostaglandins that drive inflammation, pain, and fever. By lowering prostaglandin levels at inflamed sites, it diminishes the inflammatory response while sparing COX‑1 activity that protects the stomach lining.

The appropriate dose of Melus is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Meloxicam is generally not recommended during pregnancy, especially in the third trimester, because of potential risks to the fetus. Limited data are available for breastfeeding, and the drug may pass into breast milk. Women who are pregnant, planning pregnancy, or nursing should discuss alternatives with their clinician.

To request Melus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Meloxicam offers a relatively higher selectivity for COX‑2 compared with non‑selective NSAIDs such as ibuprofen, potentially providing similar analgesic efficacy with a lower incidence of gastrointestinal irritation. However, it still carries cardiovascular and renal risks similar to other NSAIDs, so individual patient risk profiles guide the choice of therapy.

Melus should be stored at temperatures below 25 °C in its original packaging. Protect the product from moisture, heat, and direct sunlight to maintain stability and potency throughout its shelf life.

Melus is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can help reduce mild gastrointestinal discomfort that some patients experience.

Serious risks include gastrointestinal ulceration or bleeding, cardiovascular events such as heart attack or stroke, severe skin reactions (e.g., Stevens‑Johnson syndrome), hepatic injury, and renal impairment. Patients should be monitored for signs of these conditions and seek immediate medical attention if they occur.

Meloxicam is contraindicated in individuals with known hypersensitivity to meloxicam or other NSAIDs, those with active gastrointestinal ulceration or bleeding, severe heart failure, and patients who have had a recent coronary artery bypass graft. It should also be used with caution in patients with impaired renal or hepatic function.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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