Product image of Memantin Stada (Memantine Hydrochloride) supplied by GNH India

Memantin Stada

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantin Stada (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantin Stada, is a NMDA receptor antagonist presented as a tablet for oral use. It treats moderate to severe Alzheimer’s disease in adult patients who have been diagnosed with progressive cognitive decline.

GNH India supplies Memantin Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

  • Memantin Stada is an NMDA‑receptor antagonist indicated for conditions within the Alzheimer’s disease spectrum.
  • Alzheimer’s disease (moderate to severe): Improves cognition and daily functioning in patients with diagnosed moderate to severe disease.
  • Alzheimer’s disease (mild to moderate): May be added to existing therapy to support symptom control.
  • Behavioral disturbances in Alzheimer’s disease: Can help reduce agitation and aggression associated with the condition.

How It Works

  • Memantine Hydrochloride acts as a non‑competitive antagonist at the N‑methyl‑D‑aspartate (NMDA) receptor. By binding to the receptor-associated ion channel, it reduces excessive calcium influx that occurs during pathological glutamate activation, thereby limiting excitotoxic neuronal injury and supporting neuronal survival in Alzheimer’s disease.

Side Effects

Memantin Stada may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Fatigue
  • Confusion
  • Hypertension

Serious or Rare Side Effects

  • Seizures
  • Severe allergic reactions (e.g., rash, angioedema)
  • Stevens‑Johnson syndrome
  • Hepatic injury
  • Cardiac arrhythmias
  • Psychotic episodes

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety aspects.
  • Renal impairment: Adjust dose or monitor renal function closely.
  • History of seizures: Observe for increased seizure activity.
  • Cardiovascular disease: Monitor blood pressure and heart rate.
  • Concurrent NMDA antagonists: Avoid combined use to prevent additive neurotoxicity.
  • Pregnancy and lactation: Safety not established; weigh benefits against potential risks.
  • Store at room temperature: Keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Memantin Stada can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Amantadine: Additive NMDA antagonism may increase neurotoxicity.
  • Ketamine: Combined use can exacerbate neuropsychiatric effects.
  • Strong anticholinergic agents: May diminish therapeutic benefit.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: Potential for enhanced hypotensive effect.
  • Diuretics: Monitor electrolyte balance.
  • Other CNS depressants: May increase sedation or dizziness.

Frequently Asked Questions

Memantin Stada contains memantine hydrochloride, an NMDA receptor antagonist prescribed primarily for the treatment of moderate to severe Alzheimer’s disease. It helps improve cognition, functional abilities, and may reduce behavioral symptoms in patients with diagnosed disease.

Memantine hydrochloride blocks the NMDA‑type glutamate receptor in a non‑competitive manner, limiting excessive calcium entry into neurons. This reduces excitotoxic damage that contributes to neurodegeneration, thereby supporting neuronal function in Alzheimer’s disease.

The specific dose of Memantin Stada is determined by the prescribing clinician based on the patient’s condition, renal function, and response to therapy. Dosage adjustments are made according to individual therapeutic needs and safety considerations.

Safety data for memantine hydrochloride in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantin Stada belongs to the NMDA receptor antagonist class, differing from acetylcholinesterase inhibitors such as donepezil. While acetylcholinesterase inhibitors enhance cholinergic transmission, memantine reduces glutamate‑mediated excitotoxicity, offering an alternative mechanism that can be used alone or in combination with other agents.

Memantin Stada should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Memantin Stada is taken orally, usually as a tablet. The tablet should be swallowed whole with water and can be taken with or without food, following the dosing schedule prescribed by the treating physician.

Serious risks, though uncommon, include seizures, severe allergic reactions such as rash or angioedema, Stevens‑Johnson syndrome, hepatic injury, cardiac arrhythmias, and psychotic episodes. Patients should be monitored for any of these events and seek immediate medical attention if they occur.

Memantin Stada is contraindicated in patients with known hypersensitivity to memantine hydrochloride or any excipients in the formulation. Caution is advised for individuals with severe renal impairment, uncontrolled seizures, or those taking other NMDA antagonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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