Product image of Memantin Tad (Memantine Hydrochloride) supplied by GNH India

Memantin Tad

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantin Tad (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantin Tad, is a NMDA receptor antagonist presented as an oral tablet for oral use. It is indicated for the treatment of moderate to severe Alzheimer's disease in adult patients.
GNH India supplies Memantin Tad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tad Pharma Gmbh

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Indications & Clinical Uses

Memantin Tad belongs to the NMDA receptor antagonist class and is used in the management of Alzheimer's disease.

  • Moderate Alzheimer's disease: helps maintain cognitive function and daily activities.
  • Severe Alzheimer's disease: supports functional abilities and may slow decline.
  • Alzheimer's disease with behavioral symptoms: may reduce agitation and improve overall patient behavior.

How It Works

  • Memantine Hydrochloride acts as a non‑competitive antagonist at the NMDA (N‑methyl‑D‑aspartate) receptor. By binding to the receptor-associated ion channel, it reduces excessive calcium influx caused by glutamate over‑activation, thereby limiting excitotoxic neuronal injury and supporting neuronal survival in the brain.

Side Effects

Memantin Tad may cause a range of adverse reactions, most of which are mild to moderate in severity.

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Confusion
  • Fatigue
  • Hypertension

Serious or Rare Side Effects

  • Seizures
  • Severe allergic reactions (rash, swelling, anaphylaxis)
  • Hallucinations or psychosis
  • Cardiac arrhythmias

Precautions & Warnings

When prescribing Memantin Tad, clinicians should consider several safety aspects.

  • Renal impairment: dose adjustment may be required.
  • History of seizures: monitor for increased seizure activity.
  • Cardiovascular disease: observe blood pressure and heart rate.
  • Concomitant NMDA antagonists: avoid combined use to reduce toxicity risk.
  • Pregnancy and lactation: use only if clearly needed, as safety data are limited.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Memantin Tad can interact with other medicines, necessitating careful review of a patient’s medication list.

Major Interactions (Avoid)

  • Amantadine: additive NMDA antagonism may increase neurotoxicity.
  • Ketamine: combined NMDA blockade can lead to severe CNS effects.
  • High‑dose NSAIDs: may exacerbate renal impairment.

Moderate Interactions (Monitor Closely)

  • Diuretics: potential for increased hypotension.
  • Antihypertensives: additive blood‑pressure lowering effect.
  • Anticholinergic agents: may diminish cognitive benefits of memantine.
  • CYP450 inhibitors: could alter memantine plasma concentrations.

Frequently Asked Questions

Memantin Tad contains memantine hydrochloride and is prescribed for the treatment of moderate to severe Alzheimer's disease. It helps improve cognition, functional abilities, and may reduce behavioral disturbances in adult patients with this neurodegenerative condition.

Memantine acts as a non‑competitive antagonist at NMDA receptors, blocking excessive calcium entry caused by glutamate over‑activation. This reduces excitotoxic neuronal damage, helping to preserve neuronal function and slow the progression of cognitive decline associated with Alzheimer’s disease.

The appropriate dose of Memantin Tad is determined by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made individually, and patients should follow the prescriber’s instructions exactly.

Safety data for memantine during pregnancy and lactation are limited, and the pregnancy category is listed as unknown. The drug should only be used when the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request Memantin Tad, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantin Tad belongs to the NMDA receptor antagonist class, differing from acetylcholinesterase inhibitors such as donepezil. While acetylcholinesterase inhibitors enhance cholinergic transmission, memantine reduces excitotoxic glutamate activity. Both classes may be used together in some treatment regimens to target different disease pathways.

Memantin Tad should be stored at ambient temperature below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Memantin Tad is taken orally, usually as a tablet swallowed with water. The exact timing and frequency are set by the prescriber, who may start with a low dose and gradually increase it to the target maintenance dose based on tolerability.

Serious risks include seizures, severe allergic reactions such as anaphylaxis, hallucinations or psychosis, and cardiac arrhythmias. Patients should be monitored for these events, and any sudden or severe symptoms should prompt immediate medical attention.

Memantin Tad is contraindicated in patients with known hypersensitivity to memantine or any excipients in the formulation. Caution is advised for individuals with severe renal impairment, uncontrolled seizures, or those taking other NMDA antagonists, as these conditions increase the risk of adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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