Product image of Memantina Aurobindo (Memantine Hydrochloride) supplied by GNH India

Memantina Aurobindo

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantina Aurobindo (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantina Aurobindo, is a NMDA receptor antagonist presented as an oral tablet for oral use. It is used to treat moderate to severe Alzheimer’s disease in adult patients.
GNH India supplies Memantina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Generis Farmacêutica, S.A.

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Indications & Clinical Uses

Memantina Aurobindo is an NMDA‑receptor antagonist indicated for neurodegenerative conditions affecting cognition.

  • Alzheimer’s disease (moderate to severe): helps maintain cognitive function and daily living abilities.
  • Alzheimer’s disease (moderate to severe): may slow the rate of functional decline.
  • Alzheimer’s disease (moderate to severe): can improve behavioral symptoms such as agitation.

How It Works

  • Memantine Hydrochloride acts as a non‑competitive antagonist at the NMDA (N‑methyl‑D‑aspartate) receptor. By binding to the receptor’s ion channel with moderate affinity, it reduces excessive calcium influx that occurs during pathological glutamate activation, thereby limiting excitotoxic neuronal injury while preserving normal synaptic transmission.

Side Effects

Memantina Aurobindo may cause a range of adverse reactions.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Headache: mild to moderate intensity.
  • Constipation: reduced bowel movements.
  • Fatigue: feeling unusually tired.

Serious or Rare Side Effects

  • Seizures: new‑onset convulsive episodes.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety factors.

  • Renal impairment: adjust dose or monitor renal function.
  • Hepatic impairment: use with caution in patients with liver disease.
  • History of seizures: assess risk of seizure exacerbation.
  • Concomitant NMDA antagonists: avoid additive neurotoxicity.
  • Blood pressure monitoring: watch for hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Memantina Aurobindo can interact with other medicines that affect the central nervous system or NMDA pathways.

Major Interactions (Avoid)

  • Amantadine: increased risk of neurotoxic effects.
  • Ketamine: additive NMDA antagonism may cause profound CNS depression.
  • Other NMDA antagonists: heightened risk of confusion and sedation.

Moderate Interactions (Monitor Closely)

  • Anticholinergics: may diminish cognitive benefit.
  • Diuretics: can raise plasma memantine concentrations.
  • CNS depressants (e.g., benzodiazepines): may enhance sedation.

Frequently Asked Questions

Memantina Aurobindo contains memantine hydrochloride, which is prescribed for the treatment of moderate to severe Alzheimer’s disease. It helps improve cognition, daily functioning, and may reduce behavioral symptoms in adults diagnosed with this form of dementia.

Memantine acts as a non‑competitive antagonist at NMDA receptors. By blocking excessive glutamate‑mediated calcium influx, it reduces excitotoxic neuronal damage while allowing normal synaptic activity, thereby supporting cognitive function in Alzheimer’s disease.

The dosage of Memantina Aurobindo is determined by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. Physicians set the appropriate dose and titration schedule for each individual.

Safety data for memantine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Memantine belongs to the NMDA‑receptor antagonist class, differing from acetylcholinesterase inhibitors such as donepezil. While both classes aim to improve cognition, memantine targets excitotoxic pathways, and it is typically used in moderate to severe disease, often in combination with an acetylcholinesterase inhibitor for added benefit.

Memantina Aurobindo should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme temperatures to maintain its stability and potency.

The medication is taken orally, usually as a tablet, with or without food. Patients should follow the prescribing physician’s instructions regarding timing and any dose adjustments.

Serious adverse events, although rare, include seizures, severe skin reactions such as Stevens‑Johnson syndrome, and hepatic dysfunction. Patients should be monitored for these signs and seek immediate medical attention if they occur.

Memantina Aurobindo is contraindicated in patients with known hypersensitivity to memantine or any of its excipients. Caution is also advised for individuals with uncontrolled severe renal or hepatic impairment, and those taking other NMDA antagonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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