Product image of Memantina Flas Stadafarma (Memantine) supplied by GNH India

Memantina Flas Stadafarma

Active Ingredient:
Memantine
Origin:
EU

Memantina Flas Stadafarma (Memantine)

Memantine, the active ingredient in Memantina Flas Stadafarma, is a NMDA receptor antagonist presented as an oral formulation for oral use. It is used to treat moderate to severe Alzheimer’s disease in adults, helping to improve cognition and daily functioning.

GNH India supplies Memantina Flas Stadafarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution. Customers benefit from consistent product availability and comprehensive regulatory support.

Manufacturer / TM Owner

Laboratorio Stada, S.L.

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Indications & Clinical Uses

Memantine is an NMDA receptor antagonist indicated for the treatment of Alzheimer’s disease and related cognitive disorders.

  • Moderate to severe Alzheimer’s disease: improves cognition, memory, and daily functional abilities.
  • Mild to moderate Alzheimer’s disease (off‑label use): may provide modest cognitive support when combined with other therapies.
  • Behavioral symptoms of Alzheimer’s disease: can help reduce agitation and improve overall patient cooperation.

How It Works

  • Memantine acts as a non‑competitive antagonist at the N‑methyl‑D‑aspartate (NMDA) receptor ion channel. By binding within the channel at a site distinct from the glutamate binding site, it reduces excessive calcium influx caused by prolonged glutamate activation. This modulation lessens excitotoxic neuronal damage while preserving normal synaptic transmission, thereby supporting neuronal survival and function in the brain through selective inhibition of pathological signaling.

Side Effects

Memantine may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Fatigue

Serious or Rare Side Effects

  • Seizures
  • Severe allergic reactions (rash, angioedema)
  • Hepatic dysfunction

Precautions & Warnings

When prescribing memantine, clinicians should consider several safety precautions to minimize risk.

  • Renal impairment: assess kidney function and adjust dose if necessary.
  • History of seizures: monitor closely for increased seizure activity.
  • Cardiovascular disease: use with caution in patients with uncontrolled hypertension.
  • Psychiatric disorders: observe for worsening confusion or hallucinations.
  • Concomitant NMDA antagonists: avoid combined use to prevent additive neurotoxicity.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Memantine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Amantadine: additive NMDA antagonism may increase neurotoxicity.
  • Ketamine: combined NMDA blockade can lead to excessive CNS depression.
  • High‑dose NMDA agonists: may counteract therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may reduce cognitive benefit of memantine.
  • CNS depressants (e.g., benzodiazepines): can enhance sedation.
  • Diuretics (e.g., furosemide): may raise plasma memantine levels.

Frequently Asked Questions

Memantina Flas Stadafarma contains memantine, which is prescribed for the management of moderate to severe Alzheimer’s disease. It helps improve cognitive function, memory, and the ability to perform daily activities in patients with this form of dementia.

Memantine works by blocking the NMDA‑type glutamate receptors in the brain. This non‑competitive antagonism reduces excessive calcium influx that can cause neuronal injury, thereby limiting excitotoxic damage while preserving normal neurotransmission.

The specific dose of memantine is determined by the prescribing clinician based on the patient’s condition, age, renal function and other individual factors. Healthcare professionals adjust the regimen to achieve the desired therapeutic effect while monitoring safety.

Safety data for memantine in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative class for Alzheimer’s disease is acetylcholinesterase inhibitors such as donepezil. While those agents increase acetylcholine levels, memantine reduces glutamate‑mediated excitotoxicity. Both classes may be used together for complementary effects, but their mechanisms and side‑effect profiles differ.

Memantina Flas Stadafarma should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures to maintain its stability and potency.

The medication is taken orally, usually as a tablet or oral solution, as directed by the prescribing physician. It is typically swallowed with water and may be taken with or without food, depending on the clinician’s recommendation.

Serious adverse events include seizures, severe allergic reactions such as rash or angioedema, and hepatic dysfunction. Patients should be monitored for these signs, and treatment should be discontinued if any serious reaction occurs.

Memantine is contraindicated in individuals with known hypersensitivity to the drug. Caution is advised for patients with severe renal impairment, uncontrolled hypertension, or a history of seizures, as these conditions may increase the risk of adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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