Product image of Memantina Jaba (Memantine Hydrochloride) supplied by GNH India

Memantina Jaba

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantina Jaba (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantina Jaba, is an NMDA receptor antagonist presented as an oral tablet for oral use. It is indicated for the treatment of moderate to severe Alzheimer’s disease in adults, helping to reduce excitotoxic neuronal damage by non‑competitive antagonism of NMDA receptors, thereby decreasing calcium influx and neuronal injury associated with Alzheimer’s pathology.

GNH India supplies Memantina Jaba as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to European Union quality standards and provides batch‑tested product for global distribution.

Manufacturer / TM Owner

Jaba Recordati, S.A.

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Indications & Clinical Uses

  • Memantina Jaba, an NMDA receptor antagonist, is used in the management of Alzheimer’s disease.
  • Alzheimer’s disease (moderate to severe): improves cognition and functional abilities by reducing excitotoxic neuronal damage.

How It Works

  • Memantine hydrochloride binds to the phencyclidine site of the N‑methyl‑D‑aspartate (NMDA) receptor as a non‑competitive antagonist. By blocking excessive calcium influx through the receptor channel, it mitigates glutamate‑induced excitotoxicity that contributes to neuronal loss in Alzheimer’s disease, while preserving normal synaptic transmission. The drug’s moderate affinity and rapid off‑rate allow physiological activation of NMDA receptors to continue, reducing the risk of widespread inhibition.

Side Effects

Memantina Jaba may be associated with several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Confusion

Serious or Rare Side Effects

  • Hallucinations or psychosis
  • Severe hypertension
  • Allergic reactions such as skin rash or Stevens‑Johnson syndrome

Precautions & Warnings

  • Before initiating Memantina Jaba, clinicians should consider several precautionary measures to ensure safe use.
  • Renal impairment: adjust dose or monitor closely in patients with reduced kidney function.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Seizure history: monitor for increased seizure frequency.
  • Concomitant NMDA antagonists: avoid combined use due to additive effects.
  • Pregnancy and lactation: safety not established; weigh potential benefits against risks.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Memantina Jaba can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Amantadine: combined NMDA antagonism may increase neuropsychiatric adverse effects.
  • Dextromethorphan: additive NMDA blockade can lead to confusion and dizziness.

Moderate Interactions (Monitor Closely)

  • Acetylcholinesterase inhibitors (e.g., donepezil, rivastigmine): may blunt cognitive benefits; monitor response.
  • Antihypertensive agents: memantine may potentiate blood pressure lowering; observe blood pressure.
  • Diuretics: monitor electrolytes and renal function.

Frequently Asked Questions

Memantina Jaba contains memantine hydrochloride, an NMDA receptor antagonist indicated for the symptomatic treatment of moderate to severe Alzheimer’s disease in adult patients. It helps improve cognition and daily functioning by reducing excitotoxic neuronal damage.

Memantine blocks the phencyclidine site of NMDA receptors in a non‑competitive manner, limiting excessive calcium entry caused by glutamate over‑activation. This reduces excitotoxic injury to neurons while allowing normal synaptic activity, which underlies its benefit in Alzheimer’s disease.

The dosage of Memantina Jaba is individualized by the prescribing clinician based on the patient’s clinical condition, renal function, and tolerability. The prescriber determines the appropriate starting dose and titration schedule according to approved guidelines.

Safety data for memantine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Use is only considered when the potential benefit justifies the potential risk to the fetus or infant, and should be discussed with a healthcare professional.

To request Memantina Jaba, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantine belongs to the NMDA receptor antagonist class, differing from acetylcholinesterase inhibitors such as donepezil, rivastigmine, or galantamine. While cholinesterase inhibitors enhance cholinergic transmission, memantine reduces glutamate‑mediated excitotoxicity; both classes may be used together for complementary effects in moderate to severe disease.

Memantina Jaba should be stored at ambient temperature below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Memantina Jaba is taken orally, usually as a tablet, with or without food. The exact dosing schedule, including the number of tablets per day and any titration steps, is determined by the prescribing physician based on individual patient needs.

Serious adverse reactions, although uncommon, can include hallucinations, severe hypertension, and hypersensitivity reactions such as skin rash or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience these symptoms.

Memantina Jaba is contraindicated in patients with known hypersensitivity to memantine hydrochloride or any excipients in the formulation. Caution is also advised for individuals with severe renal impairment, uncontrolled seizures, or those taking other NMDA antagonists, as these conditions may increase the risk of adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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