Product image of Memantina Tad (Memantine Hydrochloride) supplied by GNH India

Memantina Tad

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantina Tad (Memantine Hydrochloride)

Memantine, the active ingredient in Memantina Tad, is a NMDA receptor antagonist presented as an oral tablet for oral use. It works by reducing excitotoxic neuronal damage and is indicated for the management of moderate to severe Alzheimer’s disease in adult patients, aiming to preserve cognition and functional abilities.

GNH India supplies Memantina Tad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for regulated markets. The company adheres to stringent quality standards and regulatory requirements.

Manufacturer / TM Owner

Tad Pharma Gmbh

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Indications & Clinical Uses

  • Memantina Tad (memantine) acts on the glutamatergic pathway and is employed in the treatment of Alzheimer’s disease.
  • Alzheimer's disease (mild to moderate): improves cognition and daily functioning in patients.
  • Alzheimer's disease (moderate to severe): helps preserve functional abilities as disease progresses.
  • Alzheimer's disease (behavioral symptoms): may reduce agitation and aggression associated with the condition.

How It Works

  • Memantine is a non‑competitive antagonist of the NMDA (N‑methyl‑D‑aspartate) receptor. By binding to the receptor-associated ion channel at a site distinct from the glutamate binding site, it blocks excessive calcium influx that occurs during pathological glutamate stimulation, thereby reducing excitotoxic neuronal injury while preserving normal synaptic transmission.

Side Effects

Memantina Tad may be associated with a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Headache: mild to moderate intensity.
  • Constipation: reduced bowel movements.
  • Confusion: occasional disorientation.
  • Hypertension: elevated blood pressure readings.
  • Fatigue: feeling of tiredness.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Seizures: convulsive episodes, especially in predisposed individuals.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Psychosis: emergence of hallucinations or delusional thoughts.

Precautions & Warnings

  • When prescribing Memantina Tad, clinicians should consider the following precautions.
  • Renal impairment: assess kidney function and adjust dose if necessary.
  • History of seizures: monitor closely for neurologic events.
  • Cardiovascular disease: evaluate blood pressure and cardiac status.
  • Concomitant NMDA antagonists: avoid combined use to prevent additive neurotoxicity.
  • Pregnancy: safety unknown; avoid unless benefits outweigh risks.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Memantina Tad can interact with other medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Amantadine: additive NMDA antagonism may increase neurotoxicity.
  • Ketamine: combined NMDA blockade can cause severe CNS depression.
  • Other NMDA antagonists: concurrent use should be avoided.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypotensive effects.
  • Antihypertensives: additive blood‑pressure lowering.
  • Anticholinergics: may worsen cognitive side effects.
  • CYP450 inhibitors: possible increase in memantine plasma levels.
  • CNS depressants: monitor for enhanced sedation.

Frequently Asked Questions

Memantina Tad contains memantine, which is prescribed for the management of moderate to severe Alzheimer’s disease. It helps to maintain cognitive function and daily living abilities by reducing excitotoxic neuronal damage associated with the disease.

Memantine acts as a non‑competitive antagonist at the NMDA receptor. By blocking excessive calcium influx during pathological glutamate activation, it limits neuronal injury while allowing normal synaptic transmission, thereby supporting brain function in Alzheimer’s patients.

The dosage of Memantina Tad is individualized. A qualified prescriber determines the starting dose and any titration schedule based on the patient’s clinical condition, renal function, and response to therapy.

Safety data for memantine in pregnancy and lactation are limited. It is classified as having an unknown pregnancy category, so it should be avoided unless the potential benefit justifies the potential risk to the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Memantine belongs to the NMDA‑receptor antagonist class, whereas cholinesterase inhibitors (e.g., donepezil, rivastigmine) increase acetylcholine levels. Memantine is typically used in moderate to severe stages, often in combination with a cholinesterase inhibitor, offering a complementary mechanism of action.

Store Memantina Tad at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Memantina Tad is taken orally as a tablet. Patients should swallow the tablet whole with a glass of water, with or without food, following the dosing schedule prescribed by their healthcare professional.

Serious adverse events, although rare, include Stevens‑Johnson syndrome, seizures, significant hepatic dysfunction, cardiac arrhythmias, and psychotic reactions. Any of these symptoms require immediate medical evaluation and possible discontinuation of therapy.

Memantina Tad is contraindicated in patients with known hypersensitivity to memantine or any tablet excipients. Caution is advised for individuals with severe renal impairment, uncontrolled hypertension, or a history of seizures, and it should be avoided in pregnancy unless absolutely necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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