Product image of Memantina Tecnigen (Memantine Hydrochloride) supplied by GNH India

Memantina Tecnigen

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantina Tecnigen (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantina Tecnigen, is a NMDA receptor antagonist presented as an oral tablet for oral use. It is used to treat Alzheimer’s disease in adult patients, helping to preserve cognition and functional abilities.

GNH India supplies Memantina Tecnigen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pentafarma - Sociedade Tecnico-Medicinal S.A.

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Indications & Clinical Uses

Memantina Tecnigen is an NMDA receptor antagonist indicated for Alzheimer’s disease and related cognitive disorders.

  • Alzheimer’s disease (moderate to severe): improves cognition and daily functioning.
  • Alzheimer’s disease (mild to moderate) as adjunct therapy: may support cognitive performance when combined with cholinesterase inhibitors.
  • Behavioral disturbances in Alzheimer’s disease: may reduce agitation and aggression.

How It Works

  • Memantine Hydrochloride acts as a non‑competitive antagonist at the NMDA‑type glutamate receptor. By binding to the receptor-associated ion channel, it blocks excessive calcium influx caused by prolonged glutamate activation, thereby reducing excitotoxic neuronal injury and helping to preserve synaptic function in the brain.

Side Effects

Common Side Effects

  • Dizziness: mild to moderate vertigo.
  • Headache: transient cranial pain.
  • Constipation: reduced bowel movements.
  • Confusion: occasional disorientation.
  • Fatigue: feeling of tiredness.
  • Hypertension: mild increase in blood pressure.

Serious or Rare Side Effects

  • Seizures: rare convulsive episodes.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Hepatic dysfunction: elevated liver enzymes.
  • Suicidal thoughts: emergence of depressive ideation.
  • Psychosis: hallucinations or delusional thinking.

Precautions & Warnings

Memantina Tecnigen should be used with caution in specific clinical situations.

  • Renal impairment: assess kidney function and consider dose adjustment.
  • Hepatic impairment: monitor liver enzymes regularly.
  • Cardiovascular disease: observe blood pressure and heart rhythm.
  • Concomitant NMDA agonists: avoid combined use due to antagonistic effects.
  • Pregnancy: risk unknown; use only if potential benefit justifies the risk.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Memantina Tecnigen may interact with other medicines; monitoring is advised.

Major Interactions (Avoid)

  • Amantadine: concurrent NMDA agonist may reduce efficacy.
  • Ketamine: additive NMDA antagonism may increase neurotoxicity risk.
  • Strong CYP450 inhibitors (e.g., quinidine): may raise memantine plasma levels.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may exacerbate cognitive side effects.
  • Diuretics: monitor electrolyte balance and renal function.
  • CNS depressants (e.g., benzodiazepines): may increase sedation.
  • Antihypertensives: watch for additive blood pressure effects.

Frequently Asked Questions

Memantina Tecnogen contains memantine hydrochloride and is prescribed for the treatment of Alzheimer’s disease. It helps to maintain cognitive function and daily activities in patients with moderate to severe disease.

Memantine hydrochloride blocks the NMDA‑type glutamate receptor in a non‑competitive manner, preventing excessive calcium influx that can cause neuronal damage. This action reduces excitotoxicity and supports neuronal health.

The specific dose and titration schedule are determined by the prescribing clinician based on the patient’s condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions.

The safety of memantine hydrochloride in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies any possible risk to the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Memantine is an NMDA receptor antagonist, whereas cholinesterase inhibitors such as donepezil act by increasing acetylcholine levels. Memantine is typically used in moderate to severe disease and can be combined with cholinesterase inhibitors for additive benefit.

Store the tablets at ambient temperature, below 25 °C, in the original packaging. Keep them away from moisture, heat and direct sunlight to maintain product stability.

Memantina Tecnogen is taken orally, usually with or without food, as directed by the prescriber. Swallow the tablet whole with water; do not crush or chew unless instructed otherwise.

Serious adverse events can include seizures, cardiac arrhythmias, severe allergic reactions, hepatic dysfunction, and emergence of suicidal thoughts. Patients should seek immediate medical attention if any of these occur.

Patients with known hypersensitivity to memantine or any excipients, those with severe renal impairment without dose adjustment, and individuals taking other NMDA agonists should avoid using Memantina Tecnogen unless medically justified.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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