Product image of Memantina Zidrium Teva (Memantine) supplied by GNH India

Memantina Zidrium Teva

Active Ingredient:
Memantine
Origin:
EU

Memantina Zidrium Teva (Memantine)

Memantine, the active ingredient in Memantina Zidrium, is an NMDA receptor antagonist presented as an oral dosage form for oral use. It is indicated for the treatment of mild to moderate Alzheimer’s disease in adult patients.

GNH India supplies Memantina Zidrium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Its global distribution network ensures timely delivery and compliance with local regulatory requirements.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Memantine is used in the management of Alzheimer’s disease, targeting glutamatergic neurotransmission.

  • Mild to moderate Alzheimer’s disease: improves cognitive function and daily living activities.
  • Moderate to severe Alzheimer’s disease: helps maintain functional abilities and may slow disease progression.
  • Behavioral symptoms of Alzheimer’s disease: may reduce agitation and aggression.

How It Works

  • Memantine acts as a non‑competitive antagonist at the N‑methyl‑D‑aspartate (NMDA) receptor. By binding to the receptor-associated ion channel with moderate affinity, it reduces excessive calcium influx caused by prolonged glutamate activation. This modulation limits excitotoxic neuronal injury while preserving normal synaptic transmission, thereby helping to protect neurons in Alzheimer’s disease. The drug’s voltage‑dependent blocking properties allow it to preferentially inhibit pathological over‑activation without disrupting physiological signaling.

Side Effects

Memantine may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Confusion
  • Hypertension

Serious or Rare Side Effects

  • Seizures
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Hepatic dysfunction
  • Suicidal thoughts or behavior

Precautions & Warnings

When prescribing memantine, clinicians should consider several safety factors.

  • Renal impairment: dose adjustment may be required and renal function should be monitored.
  • Hepatic impairment: use with caution and monitor liver enzymes.
  • History of seizures: evaluate risk and monitor for seizure activity.
  • Elderly patients: observe for increased confusion, dizziness, or falls.
  • Concomitant NMDA antagonists: avoid combined use to prevent additive neurotoxicity.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Memantine can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Amantadine: additive NMDA antagonism may increase neurotoxicity.
  • Ketamine: combined CNS depression and enhanced psychotomimetic effects.
  • Other NMDA receptor antagonists: risk of excessive inhibition of glutamatergic signaling.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: memantine may potentiate blood pressure lowering.
  • Central nervous system depressants (e.g., benzodiazepines): may increase dizziness and sedation.
  • Diuretics: may alter serum electrolytes affecting memantine’s renal clearance.

Frequently Asked Questions

Memantina Zidrium contains memantine, which is prescribed to treat mild to moderate Alzheimer’s disease. It works by modulating glutamate activity in the brain, helping to improve cognition and daily functioning in affected adults.

Memantine is a non‑competitive antagonist of the NMDA receptor. By blocking excessive calcium influx caused by over‑activation of glutamate pathways, it reduces neuronal excitotoxicity while preserving normal synaptic signaling, thereby offering neuroprotective benefits in Alzheimer’s disease.

The dosage of Memantina Zidrium is determined by the prescribing clinician based on the patient’s condition, renal function, and tolerability. Healthcare professionals follow approved labeling and clinical guidelines to establish the appropriate regimen.

The safety of memantine in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To request Memantina Zidrium, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantine belongs to the NMDA receptor antagonist class, whereas other approved agents such as cholinesterase inhibitors (e.g., donepezil) target acetylcholine metabolism. Memantine is often used alone or in combination with a cholinesterase inhibitor to address different aspects of disease pathology.

Memantina Zidrium should be stored at ambient temperature, below 25 °C. Keep the tablets in the original container, protect them from moisture and direct light, and ensure they are out of reach of children.

The product is taken orally, usually with or without food, as directed by the prescribing physician. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious adverse events, though rare, can include seizures, severe skin reactions such as Stevens‑Johnson syndrome, hepatic dysfunction, and emergence of suicidal thoughts or behavior. Patients should be monitored closely for any of these signs and seek immediate medical attention if they occur.

Memantina Zidrium is contraindicated in patients with known hypersensitivity to memantine or any of the tablet’s excipients. Caution is advised for individuals with severe renal or hepatic impairment, a history of seizures, or those taking other NMDA antagonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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