Product image of Memantina Zidrium Teva (Memantine Hydrochloride) supplied by GNH India

Memantina Zidrium Teva

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantina Zidrium Teva (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantina Zidrium Teva, is a NMDA receptor antagonist presented as a tablet for oral use. It is used to treat cognitive symptoms of Alzheimer’s disease in adult patients.
GNH India supplies Memantina Zidrium Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Memantine Hydrochloride acts on the glutamatergic pathway and is indicated for Alzheimer’s disease.

  • Alzheimer’s disease (mild to moderate): may improve memory, thinking and daily functioning.
  • Alzheimer’s disease (severe): may help maintain functional abilities and slow decline.

How It Works

  • Memantine Hydrochloride binds to the NMDA receptor at a site distinct from the glutamate binding site, acting as a non‑competitive antagonist. By reducing excessive calcium influx, it limits excitotoxic neuronal damage and helps preserve synaptic function, which can mitigate cognitive decline in Alzheimer’s disease.

Side Effects

Memantina Zidrium Teva may cause a range of adverse reactions.

Common Side Effects

  • Dizziness: mild to moderate sensation of light‑headedness.
  • Headache: transient cranial pain.
  • Constipation: reduced bowel movements.
  • Fatigue: feeling unusually tired.
  • Nausea: mild stomach upset.
  • Cough: non‑productive throat irritation.

Serious or Rare Side Effects

  • Seizures: convulsive episodes requiring immediate medical attention.
  • Hallucinations: visual or auditory disturbances.
  • Severe rash or skin reactions: including Stevens‑Johnson syndrome.
  • Hyponatremia: low blood sodium levels.
  • Liver enzyme elevation: abnormal liver function tests.
  • Mood changes: depression or suicidal thoughts.

Precautions & Warnings

Before prescribing Memantina Zidrium Teva, clinicians should consider several safety aspects.

  • Renal impairment: adjust dose in moderate to severe kidney disease.
  • History of seizures: monitor closely for increased seizure risk.
  • Cardiovascular disease: use cautiously in patients with unstable conditions.
  • Concomitant CNS depressants: may enhance dizziness or sedation.
  • Pregnancy and breastfeeding: only if potential benefit outweighs risk.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Avoid Interactions

Memantina Zidrium Teva can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Amantadine: combined NMDA antagonism may increase neurotoxicity.
  • Ketamine: additive CNS effects and risk of severe dizziness.

Moderate Interactions (Monitor Closely)

  • Anticholinesterase inhibitors (e.g., donepezil): may affect overall cognitive response.
  • Diuretics: potential for electrolyte imbalance, especially hyponatremia.
  • CNS depressants (e.g., benzodiazepines): may enhance sedation and dizziness.

Frequently Asked Questions

Memantina Zidrium Teva contains memantine hydrochloride and is prescribed to treat the cognitive symptoms of Alzheimer’s disease, helping to improve memory, thinking and daily functioning in adult patients.

Memantine hydrochloride acts as a non‑competitive antagonist at the NMDA receptor, reducing excessive calcium influx and limiting excitotoxic neuronal damage, which can slow the progression of cognitive decline in Alzheimer’s disease.

The dose is individualized by the prescribing clinician. Typically, treatment begins with a low dose that is gradually increased, but the exact regimen depends on the patient’s condition, renal function and tolerability.

Safety data are limited. The product should only be used during pregnancy or lactation if the potential benefit justifies the possible risk to the fetus or infant, and it should be decided by a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative for Alzheimer’s disease is the acetylcholinesterase inhibitor class (e.g., donepezil). While both aim to improve cognition, memantine targets glutamatergic excitotoxicity, whereas acetylcholinesterase inhibitors enhance cholinergic transmission. Choice depends on disease stage, patient tolerance and clinician judgment.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure the packaging remains sealed until use.

The medication is taken orally, with or without food, as directed by the prescriber. Tablets should be swallowed whole with water and not crushed or chewed unless specifically advised.

Serious adverse reactions include seizures, hallucinations, severe skin reactions such as Stevens‑Johnson syndrome, hyponatremia, and significant liver enzyme elevations. Patients should seek immediate medical attention if any of these occur.

Patients with known hypersensitivity to memantine or any tablet components, those with severe renal impairment without dose adjustment, and individuals with uncontrolled epilepsy should avoid using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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