Product image of Memantine Accord (Memantine Hydrochloride) supplied by GNH India

Memantine Accord

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantine Accord (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantine Accord, is a NMDA receptor antagonist presented as a tablet for oral use. It is indicated for the treatment of moderate to severe Alzheimer’s disease in adult patients.

GNH India supplies Memantine Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Memantine Accord is an NMDA receptor antagonist used in the management of dementia, particularly Alzheimer’s disease.

  • Alzheimer’s disease (moderate to severe): helps maintain cognitive function and daily living activities.
  • Alzheimer’s disease (behavioral symptoms): may reduce agitation and aggression.
  • Alzheimer’s disease (functional decline): may slow the progression of functional loss.

How It Works

  • Memantine Hydrochloride acts as a non‑competitive antagonist at the NMDA (N‑methyl‑D‑aspartate) receptor. By binding to the receptor-associated ion channel, it blocks excessive calcium influx caused by prolonged glutamate activation, thereby reducing excitotoxic neuronal injury that contributes to cognitive decline in Alzheimer’s disease.

Side Effects

Adverse reactions to Memantine Accord can vary in frequency and severity.

Common Side Effects

  • Dizziness: mild to moderate sensation of light‑headedness.
  • Headache: transient cranial discomfort.
  • Constipation: reduced bowel movements.
  • Fatigue: feeling of tiredness.
  • Nausea: mild gastrointestinal upset.
  • Cough: non‑productive throat irritation.

Serious or Rare Side Effects

  • Seizures: rare occurrence of convulsive episodes.
  • Hyponatremia: low blood sodium levels.
  • Allergic reaction: rash, itching, or swelling.
  • Hallucinations: visual or auditory disturbances.
  • Severe dizziness: risk of falls.
  • Cardiac arrhythmia: irregular heart rhythm.

Precautions & Warnings

Before prescribing Memantine Accord, clinicians should consider several safety aspects.

  • Renal impairment: adjust dose or monitor renal function.
  • Hepatic disease: use with caution in liver dysfunction.
  • Concomitant CNS depressants: monitor for additive sedation.
  • History of seizures: assess risk before initiation.
  • Pregnancy and breastfeeding: avoid unless benefit outweighs risk.
  • Store at room temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Memantine Accord may interact with other medicines, requiring attention to the interaction level.

Major Interactions (Avoid)

  • Amantadine: combined NMDA antagonism may increase neurotoxicity.
  • High‑dose anticholinergics: may worsen cognitive impairment.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may reduce absorption, monitor efficacy.
  • Diuretics: potential for electrolyte imbalance, especially hyponatremia.
  • Other NMDA antagonists: additive effects on CNS, watch for dizziness.
  • Anticonvulsants: may alter seizure threshold.
  • CNS depressants: increased sedation risk.

Frequently Asked Questions

Memantine Accord contains memantine hydrochloride, an NMDA receptor antagonist prescribed to treat moderate to severe Alzheimer’s disease. It helps improve cognition, daily functioning, and may reduce behavioral symptoms in adult patients.

Memantine blocks the NMDA‑type glutamate receptors in a non‑competitive manner, preventing excessive calcium entry into neurons. This reduces glutamate‑induced excitotoxicity, which is thought to contribute to neuronal loss and cognitive decline in Alzheimer’s disease.

The dosage of Memantine Accord is individualized by the prescribing clinician based on the patient’s condition, renal function, and tolerability. The prescriber determines the appropriate strength, titration schedule, and maintenance dose.

Safety data for memantine in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Memantine Accord, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantine belongs to the NMDA receptor antagonist class, whereas other approved agents such as donepezil, rivastigmine and galantamine are acetylcholinesterase inhibitors. Memantine is typically used in moderate to severe stages, often in combination with an acetylcholinesterase inhibitor for complementary mechanisms.

Memantine Accord should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, direct sunlight, and keep them out of reach of children.

Memantine Accord is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with water and not crushed or chewed unless otherwise instructed.

Serious adverse events, though uncommon, include seizures, hyponatremia, severe dizziness leading to falls, and rare allergic reactions such as rash or swelling. Patients should be monitored for these signs, especially during dose adjustments.

Memantine Accord is contraindicated in patients with known hypersensitivity to memantine or any excipients in the tablet. Caution is advised for individuals with severe renal impairment, uncontrolled epilepsy, or those taking interacting NMDA antagonists without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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