Product image of Memantine Aurobindo (Memantine Hydrochloride) supplied by GNH India

Memantine Aurobindo

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantine Aurobindo (Memantine Hydrochloride)

Memantine hydrochloride, the active ingredient in Memantine Aurobindo, is an NMDA receptor antagonist presented as an oral tablet for oral use. It is indicated for the symptomatic treatment of moderate to severe Alzheimer’s disease in adults. The medication works by modulating glutamatergic activity in the brain and is typically administered once daily as part of standard therapeutic regimens for cognitive decline associated with Alzheimer’s disease.\n\nGNH India supplies Memantine Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

  • Memantine, an NMDA receptor antagonist, is used in the management of Alzheimer’s disease, the most common cause of dementia.\nAlzheimer’s disease (moderate to severe): provides symptomatic improvement in cognition, memory, language, and the ability to perform daily activities, helping to maintain functional independence and may delay progression of functional decline for as long as possible.\nAlzheimer’s disease with behavioral disturbances: may reduce agitation, aggression, and psychotic symptoms, and may improve sleep quality, contributing to overall patient and caregiver management.

How It Works

  • Memantine hydrochloride acts as a non‑competitive antagonist at the NMDA‑type glutamate receptor. By binding to the receptor-associated ion channel with moderate affinity, it reduces excessive calcium influx that occurs during pathological glutamate stimulation, thereby decreasing excitotoxic neuronal injury while preserving normal synaptic transmission. This modulation helps to stabilize neuronal activity in brain regions involved in learning and memory, such as the hippocampus and cortex, without causing complete blockade of physiological glutamate signaling.

Side Effects

  • Memantine may be associated with several adverse reactions, most of which are mild, reversible, and dose‑dependent in many patients.\n\nCommon Side Effects:\n- Dizziness: a transient sensation of light‑headedness that usually resolves without intervention.\n- Headache: mild to moderate pain often alleviated by simple analgesics.\n- Constipation: reduced bowel movements that can be managed with dietary fiber or laxatives.\n\nSerious or Rare Side Effects:\n- Severe skin reactions (e.g., Stevens‑Johnson syndrome or toxic epidermal necrolysis): require immediate medical attention and discontinuation of therapy.\n- Seizures: new‑onset convulsions that may necessitate neurologic evaluation and possible cessation of the drug.\n- Hepatic dysfunction: elevated liver enzymes or hepatitis, monitored through laboratory testing and may need drug withdrawal.

Precautions & Warnings

  • When prescribing Memantine, clinicians should consider several precautionary measures to ensure patient safety.\nRenal impairment: adjust dose or monitor renal function in patients with reduced clearance.\nConcomitant CNS disorders: use caution in patients with a history of seizures or psychosis.\nCardiovascular disease: monitor blood pressure and heart rate as dizziness may affect hemodynamics.\nPregnancy and lactation: safety has not been established; avoid use unless potential benefit justifies potential risk.\nStore at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

  • Memantine can interact with other medicines, altering its efficacy or safety profile.\n\nMajor Interactions (Avoid):\n- Amantadine: concurrent use may lead to additive NMDA antagonism and increase risk of dizziness, confusion, or other CNS adverse effects.\n- Ketamine: combined NMDA blockade can result in severe neuropsychiatric reactions and should be avoided.\n\nModerate Interactions (Monitor Closely):\n- Anticholinesterase inhibitors (e.g., donepezil, rivastigmine): may require dose adjustment as combined therapy can affect cognitive outcomes.\n- Loop diuretics (e.g., furosemide): reduced renal clearance may raise memantine plasma levels, necessitating monitoring.\n- Central nervous system depressants (e.g., benzodiazepines): may enhance sedation and dizziness, warranting careful observation.

Frequently Asked Questions

Memantine Aurobindo contains memantine hydrochloride, which is prescribed to treat the cognitive symptoms of moderate to severe Alzheimer’s disease. It helps improve memory, thinking, and the ability to perform daily activities in patients with this form of dementia.

Memantine works by acting as a non‑competitive antagonist at NMDA‑type glutamate receptors. By limiting excessive calcium entry during abnormal glutamate activity, it reduces neuronal excitotoxicity while preserving normal synaptic signaling, which can help protect brain cells involved in learning and memory.

The specific dose of Memantine Aurobindo is determined by the prescribing healthcare professional based on the patient’s condition, age, renal function, and other clinical factors. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety data for memantine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide,

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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