Product image of Memantine Cristers (Memantine Hydrochloride) supplied by GNH India

Memantine Cristers

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantine Cristers (Memantine Hydrochloride)

Memantine, the active ingredient in Memantine Cristers, is a NMDA receptor antagonist presented as an oral tablet for oral use. It is indicated for the symptomatic treatment of moderate to severe Alzheimer’s disease in adults, helping to improve cognition and daily functioning.

GNH India supplies Memantine Cristers as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Cristers

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Memantine acts on the glutamatergic pathway and is used primarily in the management of Alzheimer’s disease, where excessive NMDA receptor activation contributes to neuronal injury.
  • Alzheimer’s disease: improves cognition, memory, and functional abilities in patients with moderate to severe disease.

How It Works

  • Memantine binds to the NMDA (N‑methyl‑D‑aspartate) receptor at a site distinct from the glutamate binding site, acting as a non‑competitive antagonist. By blocking prolonged calcium influx through the receptor channel, it reduces excitotoxic neuronal damage while preserving normal synaptic transmission, thereby supporting neuronal function in Alzheimer’s disease.

Side Effects

Memantine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Fatigue
  • Confusion
  • Hypertension

Serious or Rare Side Effects

  • Seizures
  • Cardiac arrhythmias
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Hepatic dysfunction
  • Suicidal thoughts or behavior
  • Severe rash or hypersensitivity reactions

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient-specific factors and monitor for potential complications.

  • Renal function: adjust dose in moderate to severe impairment.
  • History of seizures: monitor closely for increased seizure risk.
  • Cardiovascular disease: assess blood pressure and heart rhythm regularly.
  • Hepatic impairment: use with caution and monitor liver enzymes.
  • Concomitant NMDA antagonists: avoid combined use to prevent additive toxicity.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Memantine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Amantadine: combined NMDA antagonism may increase neurotoxicity.
  • Ketamine: additive CNS depression and cognitive impairment.
  • Dextromethorphan: heightened risk of dizziness and confusion.

Moderate Interactions (Monitor Closely)

  • Acetylcholinesterase inhibitors (e.g., donepezil): monitor for additive cognitive effects.
  • CNS depressants (e.g., benzodiazepines): observe for enhanced sedation.
  • Drugs affecting renal clearance (e.g., cimetidine, NSAIDs): adjust memantine dose if needed.

Frequently Asked Questions

Memantine Cristers contains memantine hydrochloride and is prescribed for the symptomatic treatment of moderate to severe Alzheimer’s disease. It helps improve cognitive function, memory, and daily living activities by reducing excitotoxic neuronal damage associated with the disease.

Memantine acts as a non‑competitive antagonist at the NMDA receptor, blocking excessive calcium influx that can lead to neuronal injury. By moderating this pathway, it helps protect brain cells while allowing normal neurotransmission, which can support cognition in Alzheimer’s patients.

The dosing regimen for Memantine Cristers is determined by the prescribing physician based on the patient’s clinical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for memantine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Memantine belongs to the NMDA receptor antagonist class, whereas other approved agents such as donepezil, rivastigmine, and galantamine are acetylcholinesterase inhibitors. Memantine is typically used in moderate to severe stages, often in combination with an acetylcholinesterase inhibitor for additive benefit.

Memantine Cristers should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, heat, and direct sunlight to maintain stability and potency throughout its shelf life.

Memantine Cristers is taken orally, usually once daily with or without food, as directed by the prescriber. The tablet should be swallowed whole with water and not crushed or chewed unless specifically instructed.

Serious adverse events, though rare, can include seizures, cardiac arrhythmias, severe skin reactions such as Stevens‑Johnson syndrome, hepatic dysfunction, and suicidal thoughts. Patients should be monitored closely for any of these symptoms and seek immediate medical attention if they occur.

Memantine Cristers is contraindicated in patients with known hypersensitivity to memantine or any of its excipients. Caution is advised for individuals with severe renal impairment, uncontrolled epilepsy, or those taking other NMDA antagonists, as these conditions increase the risk of adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.