Product image of Memantine Hydrochloride Crescent Pharma (Memantine Hydrochloride) supplied by GNH India

Memantine Hydrochloride Crescent Pharma

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantine Hydrochloride Crescent Pharma (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantine Hydrochloride Crescent Pharma, is an NMDA receptor antagonist presented as an oral tablet for oral use. It treats Alzheimer’s disease in adults by helping to preserve cognitive function and daily activities.

GNH India supplies Memantine Hydrochloride Crescent Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Crescent Pharma Limited

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Indications & Clinical Uses

  • Memantine Hydrochloride is a NMDA‑receptor antagonist used in the management of Alzheimer’s disease, a neurodegenerative disorder affecting memory and cognition.
  • Alzheimer's disease (moderate to severe): helps maintain cognitive function and daily living abilities.
  • Alzheimer's disease (mild to moderate): may support early symptom control and delay functional decline.

How It Works

  • Memantine Hydrochloride acts as a non‑competitive antagonist at the NMDA (N‑methyl‑D‑aspartate) receptor. By binding to the receptor-associated ion channel, it reduces excessive calcium influx caused by overstimulation, thereby limiting excitotoxic neuronal injury and supporting neuronal survival in the brain.

Side Effects

Memantine is generally well tolerated, but several adverse reactions have been reported.

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Confusion
  • Hypertension
  • Insomnia

Serious or Rare Side Effects

  • Seizures
  • Cardiac arrhythmia
  • Severe allergic reaction (rash, swelling, anaphylaxis)
  • Hallucinations or psychosis
  • Suicidal thoughts or behavior
  • Liver function abnormalities

Precautions & Warnings

When prescribing Memantine Hydrochloride, clinicians should consider several safety factors.

  • Renal impairment: adjust dose and monitor renal function.
  • Hepatic impairment: use with caution and monitor liver enzymes.
  • History of seizures: evaluate risk before initiating therapy.
  • Concurrent use with other NMDA antagonists: avoid additive neuro‑psychiatric effects.
  • Pregnancy: risk unknown; use only if clearly needed.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Memantine Hydrochloride may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Amantadine: additive NMDA antagonism may increase neuro‑psychiatric effects.
  • Ketamine: combined CNS depression and dissociation risk.
  • Moxifloxacin: heightened seizure potential.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible enhanced hypotensive effect.
  • Diuretics: may affect electrolyte balance and renal clearance.
  • Other CNS depressants (e.g., benzodiazepines): monitor for increased sedation.

Frequently Asked Questions

Memantine Hydrochloride Crescent Pharma is prescribed to treat Alzheimer’s disease. It works by modulating glutamate activity at NMDA receptors, which helps protect neurons from excitotoxic damage and may improve cognition and daily functioning in patients with mild to severe disease.

The drug acts as a non‑competitive antagonist of the NMDA receptor. By blocking the receptor’s ion channel, it reduces excessive calcium influx that can lead to neuronal injury, thereby limiting excitotoxicity and supporting neuronal health in the brain.

The dosage of Memantine Hydrochloride is individualized by the prescribing clinician based on the patient’s condition, renal function, and tolerability. The prescriber determines the appropriate starting dose and titration schedule.

Safety data for Memantine Hydrochloride in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, so it should only be used if the potential benefit justifies the potential risk to the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantine belongs to the NMDA‑receptor antagonist class, whereas many other Alzheimer’s agents are acetylcholinesterase inhibitors (e.g., donepezil). Memantine is typically used in moderate to severe stages and may be combined with an acetylcholinesterase inhibitor for additive benefit, while having a distinct side‑effect profile.

Store the tablets at temperatures below 25 °C in their original container, protected from moisture and direct sunlight. Do not expose the product to excessive heat or humidity, and keep it out of reach of children.

Memantine Hydrochloride is taken orally, usually as a tablet. The patient swallows the tablet whole with water, and dosing is typically once or twice daily as directed by the prescriber.

Serious risks include seizures, cardiac arrhythmias, severe allergic reactions, and neuro‑psychiatric events such as hallucinations or suicidal thoughts. Patients should be monitored closely for any new or worsening symptoms, especially during dose adjustments.

Memantine is contraindicated in patients with known hypersensitivity to the drug. Caution is advised for individuals with severe renal impairment, uncontrolled hypertension, or a history of seizures, and it should be avoided in combination with other NMDA antagonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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