Product image of Memantine Mylan (Memantine Hydrochloride) supplied by GNH India

Memantine Mylan

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantine Mylan (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantine Mylan, is an NMDA receptor antagonist presented as an oral tablet for oral use. It is indicated for the treatment of moderate to severe Alzheimer’s disease in adults, helping to preserve cognitive function and daily living activities.

GNH India supplies Memantine Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on reliable quality, regulatory compliance, and timely delivery across Europe, Asia, Africa and the Americas.

Manufacturer / TM Owner

Mylan Pharmaceuticals Limited

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Indications & Clinical Uses

Memantine Mylan, a non‑competitive NMDA receptor antagonist, modulates glutamate‑mediated excitotoxicity and is employed in the therapeutic management of Alzheimer’s disease.

  • Moderate to severe Alzheimer’s disease: improves cognition and functional abilities in patients.
  • Behavioral symptoms of Alzheimer’s disease: may reduce agitation and aggression.
  • Functional decline in Alzheimer’s disease: helps maintain activities of daily living.

How It Works

  • Memantine Hydrochloride binds to the NMDA (N‑methyl‑D‑aspartate) receptor at a site distinct from the glutamate binding site, acting as a non‑competitive antagonist. By reducing excessive calcium influx through the receptor channel, it diminishes excitotoxic neuronal injury that contributes to cognitive decline in Alzheimer’s disease. This modulation of glutamatergic transmission helps preserve neuronal function without completely blocking normal synaptic activity.

Side Effects

Memantine Mylan may be associated with several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Headache: mild to moderate pain in the head.
  • Constipation: reduced bowel movements or hard stools.
  • Fatigue: feeling unusually tired or weak.

Serious or Rare Side Effects

  • Seizures: rare occurrence of convulsive episodes.
  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Hallucinations or psychosis: rare neuropsychiatric events.

Precautions & Warnings

When prescribing Memantine Mylan, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: adjust dose or monitor renal function in patients with reduced kidney function.
  • History of seizures: use with caution as the drug may lower seizure threshold.
  • Cardiovascular disease: monitor blood pressure and heart rate in patients with existing cardiac conditions.
  • Concomitant use with other NMDA antagonists: avoid additive neuro‑psychiatric effects.
  • Pregnancy and lactation: risk unknown; use only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Memantine Mylan can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Amantadine: combined use may increase risk of neuropsychiatric side effects.
  • Ketamine: additive NMDA antagonism can lead to excessive CNS depression.
  • High‑dose zinc supplements: may reduce memantine absorption.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may blunt cognitive benefits of memantine.
  • CNS depressants (e.g., benzodiazepines): monitor for enhanced sedation.
  • Proton pump inhibitors: may slightly increase memantine plasma levels.

Frequently Asked Questions

Memantine Mylan is prescribed for the treatment of moderate to severe Alzheimer’s disease. It helps improve cognitive function and daily living activities by reducing excitotoxic neuronal damage associated with the disease.

Memantine Hydrochloride acts as a non‑competitive antagonist at the NMDA receptor. By blocking excessive calcium influx through the receptor channel, it limits glutamate‑induced excitotoxicity, which contributes to neuronal loss in Alzheimer’s disease.

The dose of Memantine Mylan is individualized by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. No fixed regimen is provided here; the prescriber sets the appropriate dosage.

Safety data for Memantine Mylan in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To order Memantine Mylan, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantine Mylan belongs to the NMDA receptor antagonist class, whereas many other Alzheimer’s drugs are acetylcholinesterase inhibitors. Memantine targets glutamatergic excitotoxicity, offering a complementary mechanism that may be used alone or in combination with cholinergic agents for broader symptom control.

Memantine Mylan tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and keep out of reach of children.

Memantine Mylan is taken orally, usually with or without food, as directed by the prescriber. The tablets are swallowed whole with a glass of water; they should not be crushed, chewed, or dissolved unless specifically instructed.

Serious risks include the potential for seizures, severe allergic reactions such as rash or breathing difficulty, and rare neuropsychiatric events like hallucinations or psychosis. Patients should seek immediate medical attention if any of these symptoms occur.

Memantine Mylan is contraindicated in patients with known hypersensitivity to memantine or any of its excipients. Caution is advised for individuals with severe renal impairment, uncontrolled seizures, or those taking other NMDA antagonists, as the risk of adverse effects may be higher.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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