Memantine Synthon (Memantine Hydrochloride)

Memantine works by blocking the NMDA receptor’s ion channel in a non‑competitive manner. This reduces excessive calcium entry caused by high glutamate levels, limiting neuronal excitotoxicity and helping preserve brain cell function.

The dosage of memantine is individualized by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. The prescriber determines the appropriate strength and titration schedule.

Safety of memantine in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantine belongs to the NMDA receptor antagonist class, whereas other approved agents such as donepezil, rivastigmine and galantamine are acetylcholinesterase inhibitors. Memantine is typically used for moderate to severe disease and may be combined with an acetylcholinesterase inhibitor for additive benefit.

Memantine Synthon should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight to maintain stability throughout its shelf life.

The medication is taken orally, usually as a tablet, with or without food. Patients should follow the prescriber’s instructions regarding timing and any dose adjustments.

Serious risks include seizures, severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, hepatic dysfunction, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience any of these symptoms.

Memantine is contraindicated in patients with known hypersensitivity to memantine or any component of the formulation. Caution is advised for individuals with severe renal impairment, uncontrolled epilepsy, or unstable cardiovascular conditions.