Product image of Memantine Teva (Memantine) supplied by GNH India

Memantine Teva

Active Ingredient:
Memantine
Origin:
EU

Memantine Teva (Memantine)

Memantine, the active ingredient in Memantine Teva, is a NMDA receptor antagonist presented as an oral tablet for oral use. It is indicated for the treatment of moderate to severe Alzheimer's disease in adults.

GNH India supplies Memantine Teva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Memantine acts on the glutamatergic system and is used in the management of Alzheimer's disease.
  • Alzheimer's disease (moderate to severe): helps maintain cognition and daily functional abilities.
  • Alzheimer's disease (as part of combination therapy with cholinesterase inhibitors): may provide additional symptomatic benefit when used together with standard treatments.

How It Works

  • Memantine is a non‑competitive antagonist of the N‑methyl‑D‑aspartate (NMDA) receptor. By binding to the receptor-associated ion channel at a site distinct from the glutamate binding site, it reduces excessive calcium influx caused by overstimulation, thereby limiting excitotoxic neuronal injury that contributes to cognitive decline in Alzheimer's disease.

Side Effects

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Somnolence
  • Confusion
  • Fatigue

Serious or Rare Side Effects

  • Seizures
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Cardiac arrhythmias
  • Hepatic dysfunction
  • Suicidal thoughts or behavior

Precautions & Warnings

Memantine should be used with caution in specific clinical situations.

  • Renal impairment: dose adjustment may be required and renal function should be monitored.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • History of seizures: observe for increased seizure frequency.
  • Concomitant use with other NMDA antagonists: avoid due to additive neuro‑protective effects.
  • Elderly patients: higher risk of confusion and falls; start at low dose.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Memantine may interact with several medicines that affect its excretion or central nervous system activity.

Major Interactions (Avoid)

  • Other NMDA antagonists (e.g., amantadine, dextromethorphan): may increase neuro‑toxic risk.
  • Strong renal tubular secretion inhibitors (e.g., cimetidine, trimethoprim): can raise memantine plasma levels.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may blunt cognitive benefits.
  • CNS depressants (e.g., benzodiazepines, opioids): may enhance sedation.
  • Diuretics: monitor electrolytes and renal function.
  • High‑dose vitamin D supplements: may affect calcium homeostasis.

Frequently Asked Questions

Memantine Teva contains the active ingredient memantine, which is prescribed for the treatment of moderate to severe Alzheimer's disease. It helps to improve cognition and daily functioning by reducing excitotoxic neuronal damage associated with the disease.

Memantine works as a non‑competitive antagonist of NMDA receptors. By blocking excessive calcium entry through these receptors, it limits glutamate‑induced excitotoxicity, helping to protect neurons and slow the progression of cognitive decline in Alzheimer's disease.

The appropriate dose of Memantine Teva is determined by the prescribing clinician based on the patient’s condition, renal function, and response to therapy. Dosage adjustments are made individually and should follow the prescriber’s instructions.

The safety of memantine in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantine belongs to the NMDA receptor antagonist class, whereas many other Alzheimer's drugs are acetylcholinesterase inhibitors. Memantine is typically used in moderate to severe stages and can be combined with an inhibitor for added benefit, offering a different mechanism of neuroprotection.

Memantine Teva should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat and direct sunlight to maintain product stability.

Memantine Teva is taken orally, usually once daily after a meal to improve tolerability. The tablet should be swallowed whole with water and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include the potential for seizures, severe skin reactions such as Stevens‑Johnson syndrome, cardiac arrhythmias, hepatic dysfunction, and emergence of suicidal thoughts. Patients should be monitored closely for any of these events.

Memantine is contraindicated in patients with known hypersensitivity to memantine or any of the tablet’s excipients. Caution is advised in individuals with severe renal impairment, uncontrolled epilepsy, or those taking other NMDA antagonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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