Product image of Memantine Teva Sante (Memantine Hydrochloride) supplied by GNH India

Memantine Teva Sante

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantine Teva Sante (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantine Teva Sante, is a NMDA receptor antagonist presented as an oral tablet for oral use. It is indicated for the treatment of Alzheimer’s disease in adult patients.

GNH India supplies Memantine Teva Sante as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Santé

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Indications & Clinical Uses

Memantine Teva Sante is an NMDA‑receptor antagonist used in the management of Alzheimer’s disease.

  • Mild to moderate Alzheimer’s disease: improves cognition, memory and daily functional abilities.
  • Moderate to severe Alzheimer’s disease: provides modest cognitive benefit, often used in combination with cholinesterase inhibitors.
  • Adjunct therapy in Alzheimer’s disease: may enhance overall treatment response when added to standard care.

How It Works

  • Memantine Hydrochloride acts as a non‑competitive antagonist at the NMDA (N‑methyl‑D‑aspartate) receptor. By binding to the receptor-associated ion channel, it blocks excessive calcium influx caused by prolonged glutamate activation, thereby reducing excitotoxic neuronal injury and supporting neuronal survival in the brain.

Side Effects

Memantine Teva Sante may cause a range of adverse reactions.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Headache: mild to moderate intensity.
  • Constipation: reduced bowel movements.
  • Confusion: temporary mental clouding.
  • Fatigue: feeling unusually tired.
  • Hypertension: elevated blood pressure readings.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): swelling, difficulty breathing, rash.
  • Stevens‑Johnson syndrome: painful skin blistering and detachment.
  • Seizures: rare occurrence of convulsive episodes.
  • Hallucinations or psychosis: visual or auditory disturbances.
  • Significant liver enzyme elevation: abnormal liver function tests.
  • Persistent vomiting: ongoing nausea and emesis.

Precautions & Warnings

When prescribing Memantine Teva Sante, clinicians should consider several safety aspects.

  • Renal impairment: adjust dose or monitor renal function closely.
  • Hepatic impairment: use with caution and monitor liver enzymes.
  • History of seizures: observe for increased seizure activity.
  • Concomitant NMDA antagonists: avoid additive neuro‑psychiatric effects.
  • Pregnancy and breastfeeding: limited data, use only if benefit outweighs risk.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Memantine may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Amantadine: combined NMDA antagonism can increase CNS side effects.
  • Other NMDA antagonists (e.g., ketamine): risk of excessive receptor blockade.
  • Strong CYP450 inhibitors (e.g., quinidine): may raise memantine plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Anticholinesterase inhibitors (donepezil, rivastigmine): monitor for additive cognitive effects.
  • Diuretics (furosemide): may affect renal clearance of memantine.
  • Antihypertensive agents: potential enhancement of blood‑pressure‑lowering effects.
  • Antipsychotics: watch for increased confusion or sedation.
  • Anticonvulsants: possible alteration of seizure threshold.

Frequently Asked Questions

Memantine Teva Sante contains memantine hydrochloride and is prescribed to treat cognitive decline associated with Alzheimer’s disease. It helps improve memory, thinking, and the ability to perform daily activities in patients with mild to moderate disease, and may provide modest benefit in more advanced stages when used with other therapies.

Memantine works by blocking the NMDA‑type glutamate receptor in a non‑competitive manner. This reduces excessive calcium entry into neurons that occurs during prolonged glutamate stimulation, thereby limiting excitotoxic damage and supporting neuronal health, which can translate into better cognitive function in Alzheimer’s patients.

The specific dose of Memantine Teva Sante is determined by the prescribing clinician based on the patient’s condition, renal function, and response to therapy. Dosage adjustments are made individually, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety data for memantine in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss risks with their healthcare provider.

To request Memantine Teva Sante, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any special handling), and necessary import documentation.

Memantine belongs to the NMDA‑receptor antagonist class, whereas drugs such as donepezil, rivastigmine, and galantamine are cholinesterase inhibitors. Memantine targets excitotoxic pathways, while cholinesterase inhibitors enhance acetylcholine signaling. Both classes may be used together for complementary effects, but they have distinct mechanisms and side‑effect profiles.

Memantine Teva Sante tablets should be stored at temperatures below 25 °C, in their original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Memantine Teva Sante is taken orally, usually with or without food, as directed by a healthcare professional. The tablets are swallowed whole with a glass of water. Patients should not crush, chew, or split the tablets unless specifically instructed by their prescriber.

Serious risks, though uncommon, include severe allergic reactions such as anaphylaxis, skin conditions like Stevens‑Johnson syndrome, seizures, and significant elevations in liver enzymes. Patients should seek immediate medical attention if they experience rash, difficulty breathing, persistent vomiting, or new neurological symptoms.

Memantine is contraindicated in patients with known hypersensitivity to memantine hydrochloride or any of the tablet’s excipients. Caution is advised for individuals with severe renal impairment, uncontrolled hypertension, or a history of seizures, and it should be avoided in pregnant or breastfeeding women unless clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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