Product image of Memantine Vipharm (Memantine Hydrochloride) supplied by GNH India

Memantine Vipharm

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantine Vipharm (Memantine Hydrochloride)

Memantine, the active ingredient in Memantine Vipharm, is a NMDA receptor antagonist presented as an oral tablet for systemic use. It is indicated for the symptomatic treatment of moderate to severe Alzheimer’s disease in adult patients, helping to improve cognition, function and behavior.

GNH India supplies Memantine Vipharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Products are manufactured under EU GMP guidelines and undergo rigorous batch testing.

Manufacturer / TM Owner

Vipharm S.A.

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Indications & Clinical Uses

  • Memantine is indicated for the treatment of Alzheimer’s disease, a neurodegenerative disorder affecting cognition and function.
  • Alzheimer’s disease (cognitive symptoms): May help maintain or modestly improve memory and thinking abilities.
  • Alzheimer’s disease (functional abilities): May support daily living activities and overall functional performance.
  • Alzheimer’s disease (behavioral symptoms): May reduce agitation, aggression and other neuropsychiatric manifestations.

How It Works

  • Memantine acts as a non‑competitive antagonist at the N‑methyl‑D‑aspartate (NMDA) receptor ion channel. By blocking excessive calcium influx caused by prolonged glutamate activation, it reduces excitotoxic neuronal injury while preserving normal synaptic transmission, thereby helping to stabilize neuronal function in Alzheimer’s disease.

Side Effects

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Confusion
  • Somnolence
  • Hypertension

Serious or Rare Side Effects

  • Seizures
  • Cardiac arrhythmia
  • Severe allergic reactions (e.g., anaphylaxis, Stevens‑Johnson syndrome)
  • Hepatic dysfunction

Precautions & Warnings

Memantine should be used with caution in patients with the following considerations:

  • Renal impairment: assess renal function and adjust dose if necessary.
  • History of seizures: monitor closely for increased seizure activity.
  • Cardiovascular disease: observe blood pressure and heart rhythm.
  • Concomitant use of other NMDA antagonists: avoid additive neurotoxicity.
  • Psychiatric disorders: watch for worsening confusion or hallucinations.

Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Memantine may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Amantadine: increased risk of neurotoxicity and seizures.
  • Ketamine: additive NMDA antagonism may exacerbate CNS effects.
  • Strong CYP3A4 inhibitors: may raise memantine plasma levels.

Moderate Interactions (Monitor Closely)

  • Anticholinesterase inhibitors (e.g., donepezil): may increase gastrointestinal side effects.
  • CNS depressants (e.g., benzodiazepines): may enhance sedation.
  • Antihypertensive agents: possible additive blood pressure lowering.

Frequently Asked Questions

Memantine Vipharm is prescribed for the symptomatic treatment of moderate to severe Alzheimer’s disease in adults. It helps to improve cognitive function, daily living activities, and may reduce behavioral disturbances associated with the disease.

Memantine blocks the NMDA‑type glutamate receptors in a non‑competitive manner, preventing excessive calcium entry that can cause neuronal damage. This modulation reduces excitotoxicity while allowing normal synaptic activity, supporting neuronal health in Alzheimer’s disease.

The dosage of Memantine Vipharm is determined by the prescribing clinician based on the patient’s condition, renal function, and treatment response. The prescriber will set the appropriate dose and titration schedule.

Safety of memantine in pregnancy or while breastfeeding has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Memantine Vipharm, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantine belongs to the NMDA‑receptor antagonist class, whereas other approved agents such as donepezil, rivastigmine and galantamine are acetylcholinesterase inhibitors. Memantine targets excitotoxic pathways, offering a different mechanism that can be used alone or in combination with cholinesterase inhibitors for broader symptom control.

Memantine Vipharm should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct light to maintain stability throughout its shelf life.

Memantine Vipharm is taken orally, usually as a tablet swallowed with water. The exact administration schedule, including any dose titration, is determined by the prescribing physician.

Serious risks include the potential for seizures, cardiac arrhythmias, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, and hepatic dysfunction. Patients should be monitored for these events, especially if they have pre‑existing risk factors.

Memantine Vipharm is contraindicated in patients with known hypersensitivity to memantine or any of its excipients. Caution is also advised for individuals with severe renal impairment, uncontrolled epilepsy, or those taking other NMDA antagonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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