Product image of Memantinhydrochlorid Neuraxpharm (Memantine Hydrochloride) supplied by GNH India

Memantinhydrochlorid Neuraxpharm

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memantinhydrochlorid Neuraxpharm (Memantine Hydrochloride)

Memantine Hydrochloride, the active ingredient in Memantinhydrochlorid Neuraxpharm, is a NMDA receptor antagonist presented as an oral formulation for oral use. It is indicated for the treatment of moderate to severe Alzheimer’s disease in adults.
GNH India supplies Memantinhydrochlorid Neuraxpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neuraxpharm Arzneimittel Gmbh

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Indications & Clinical Uses

Memantinhydrochlorid acts on the glutamatergic pathway and is used in Alzheimer’s disease management.

  • Moderate to severe Alzheimer’s disease: improves cognition and daily functioning.
  • Mild to moderate Alzheimer’s disease (as adjunct to cholinesterase inhibitors): may provide additional benefit.
  • Dementia associated with Alzheimer’s disease: helps maintain functional abilities.

How It Works

  • Memantine Hydrochloride binds to the NMDA receptor channel at a site distinct from the glutamate binding site, acting as a non‑competitive antagonist. By reducing excessive calcium influx, it limits excitotoxic neuronal injury and helps preserve synaptic function, which may translate into clinical benefits in Alzheimer’s disease.

Side Effects

Common Side Effects

  • Dizziness: transient light‑headedness, especially at treatment initiation.
  • Headache: mild to moderate intensity, often resolves with continued therapy.
  • Constipation: reduced bowel movements, manageable with diet.
  • Confusion: occasional disorientation, typically improves over time.
  • Somnolence: mild sleepiness, may lessen with dose adjustment.
  • Hypertension: modest increase in blood pressure in some patients.

Serious or Rare Side Effects

  • Seizures: rare occurrence, requires immediate medical attention.
  • Hallucinations: visual or auditory disturbances, may need discontinuation.
  • Severe allergic reactions: rash, angioedema, or anaphylaxis.
  • Cardiac arrhythmias: irregular heart rhythms, monitor in at‑risk individuals.

Precautions & Warnings

Precautions should be observed when prescribing Memantinhydrochlorid.

  • Renal impairment: dose adjustment may be required.
  • Hepatic impairment: monitor liver function tests.
  • History of seizures: use with caution and monitor closely.
  • Concurrent use with other NMDA antagonists: increased risk of CNS effects.
  • Pregnancy and lactation: safety not established; weigh benefits against risks.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Memantinhydrochlorid may interact with several medications.

Major Interactions (Avoid)

  • Amantadine: additive NMDA antagonism may increase adverse CNS effects.
  • Ketamine: combined use can potentiate neuropsychiatric reactions.
  • Other NMDA antagonists: heightened risk of dizziness and confusion.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may worsen cognitive impairment.
  • Central nervous system depressants: increased sedation and drowsiness.
  • Diuretics: may alter plasma concentrations of memantine.

Frequently Asked Questions

Memantinhydrochlorid Neuraxpharm contains memantine hydrochloride, which is prescribed for the treatment of moderate to severe Alzheimer’s disease. It works by modulating glutamate activity in the brain, helping to improve cognition and daily functioning in affected patients.

Memantine hydrochloride acts as a non‑competitive antagonist at the NMDA receptor, blocking excessive calcium influx caused by overstimulation of glutamate. This reduces excitotoxic neuronal damage, supporting synaptic function and potentially slowing cognitive decline in Alzheimer’s disease.

The dosage of Memantinhydrochlorid Neuraxpharm is determined by the prescribing physician based on the patient’s clinical condition, renal function, and response to therapy. The prescriber will set the appropriate dose and titration schedule.

Safety of memantine hydrochloride in pregnancy and lactation has not been established. Healthcare providers should consider the potential benefits versus risks before prescribing to pregnant or nursing women, and discuss alternative options when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memantinhydrochlorid belongs to the NMDA receptor antagonist class, differing from cholinesterase inhibitors such as donepezil. While cholinesterase inhibitors increase acetylcholine levels, memantine reduces glutamate‑mediated excitotoxicity. Both classes may be used together for complementary effects in moderate to severe disease.

Store Memantinhydrochlorid Neuraxpharm at room temperature, below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Memantinhydrochlorid is administered orally, typically as a tablet taken with or without food. The exact dosing schedule and whether the tablet is taken once or twice daily are determined by the prescribing clinician.

Serious risks include the potential for seizures, severe allergic reactions such as anaphylaxis, and rare cardiac arrhythmias. Patients should be monitored for these events, and any sudden neurological or cardiovascular symptoms should prompt immediate medical evaluation.

Memantinhydrochlorid is contraindicated in patients with known hypersensitivity to memantine or any component of the formulation. Caution is advised for individuals with severe renal impairment, uncontrolled seizures, or those taking other NMDA antagonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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