Product image of Memelin (Exemestane) supplied by GNH India

Memelin

Active Ingredient:
Exemestane
Origin:
EU

Memelin (Exemestane)

Exemestane, the active ingredient in Memelin, is an aromatase inhibitor presented as an oral formulation for oral use. It treats postmenopausal breast cancer by reducing estrogen production.

GNH India supplies Memelin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Stada Hemofarm S.R.L.

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Indications & Clinical Uses

Exemestane is an aromatase inhibitor used in hormonal therapy for breast cancer.

  • Postmenopausal breast cancer: Used as adjuvant therapy to lower recurrence after surgery.
  • Hormone‑receptor positive metastatic breast cancer: Provides disease control after prior endocrine therapy failure.
  • Estrogen‑dependent tumor prevention: Inhibits estrogen synthesis to limit tumor proliferation.

How It Works

  • Exemestane irreversibly binds to the aromatase enzyme, blocking the conversion of androgens to estrogen. This leads to a marked reduction in circulating estrogen levels, decreasing estrogen‑driven stimulation of hormone‑receptor positive breast cancer cells and slowing tumor growth.

Side Effects

Exemestane may cause a range of adverse reactions.

Common Side Effects

  • Hot flashes: Sudden feeling of warmth and sweating.
  • Joint pain: Musculoskeletal discomfort, especially in knees and hips.
  • Fatigue: Persistent tiredness not relieved by rest.
  • Nausea: Mild to moderate upset stomach.

Serious or Rare Side Effects

  • Severe liver injury: Elevated liver enzymes or hepatitis requiring medical attention.
  • Thromboembolic events: Deep vein thrombosis or pulmonary embolism that may be life‑threatening.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess liver function: Obtain baseline hepatic enzymes and monitor periodically.
  • Monitor bone health: Evaluate risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Evaluate cardiovascular risk: Watch for signs of thrombosis, especially in high‑risk patients.
  • Avoid use in pregnancy: Contraindicated in women of childbearing potential; ensure effective contraception.
  • Store at ambient temperature: Keep below 25°C in the original pack, protect from moisture.

Avoid Interactions

Exemestane can interact with several drug classes.

Major Interactions (Avoid)

  • Estrogen‑containing hormone therapy: Negates the aromatase‑inhibiting effect.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): Decrease plasma concentrations of exemestane.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin): May increase bleeding tendency; monitor INR.
  • Selective serotonin reuptake inhibitors: Can exacerbate hot flashes.
  • Tamoxifen: Potential antagonistic effect; clinical efficacy should be monitored.

Frequently Asked Questions

Memelin contains the active ingredient exemestane, an aromatase inhibitor indicated for the treatment of hormone‑receptor positive breast cancer in postmenopausal women, both as adjuvant therapy after surgery and for disease control in metastatic settings.

Exemestane irreversibly binds to the aromatase enzyme, preventing the conversion of androgens into estrogen. This reduces circulating estrogen levels, limiting the growth stimulus for estrogen‑dependent breast cancer cells.

The prescribed dose of Memelin is determined by the treating physician based on the patient’s clinical condition, treatment history, and regulatory guidelines. Patients should follow the exact dosing instructions provided by their healthcare professional.

Exemestane is contraindicated in pregnancy and is not recommended for breastfeeding women because it can affect fetal development and pass into breast milk. Effective contraception should be used during treatment and for a period after discontinuation.

To order Memelin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Memelin (exemestane) is a steroidal, irreversible aromatase inhibitor, whereas agents like letrozole and anastrozole are non‑steroidal and reversible. Clinical choice depends on patient tolerance, prior therapy, and specific safety profiles, with exemestane often used after tamoxifen failure.

Memelin should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability.

Memelin is taken orally, usually with water. The tablet should be swallowed whole and not crushed or chewed, unless otherwise directed by a healthcare professional.

The most serious risks include severe liver injury and thromboembolic events such as deep‑vein thrombosis or pulmonary embolism. Patients should be monitored for signs of hepatic dysfunction or unusual swelling, pain, or shortness of breath.

Memelin should not be used by women who are pregnant, may become pregnant, or are breastfeeding. It is also contraindicated in patients with known hypersensitivity to exemestane or any of the tablet’s excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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