Product image of Memo (Galantamine Hydrobromide) supplied by GNH India

Memo

Active Ingredient:
Galantamine Hydrobromide
Origin:
EU

Memo (Galantamine Hydrobromide)

Galantamine, the active ingredient in Memo, is an acetylcholinesterase inhibitor presented as an oral tablet for systemic use. It is indicated for the symptomatic treatment of mild to moderate Alzheimer’s disease in adult patients, helping to improve cognition and daily functioning.

GNH India supplies Memo as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide under strict quality‑assurance standards and regulatory oversight. The company ensures traceability, proper packaging, and compliance with EU and global pharmacopeial specifications for each shipment.

Manufacturer / TM Owner

Farmellas Enterprises Ltd

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Indications & Clinical Uses

  • Galantamine is used in the management of Alzheimer’s disease, a neurodegenerative disorder affecting memory and cognition.
  • Alzheimer’s disease (mild to moderate): improves cognitive function and slows decline in daily activities.
  • Memory loss in Alzheimer’s disease: helps preserve short‑term memory capabilities.
  • Activities of daily living in Alzheimer’s disease: supports functional performance and independence.

How It Works

  • Galantamine reversibly inhibits acetylcholinesterase, the enzyme that breaks down acetylcholine in the synaptic cleft, thereby increasing synaptic acetylcholine concentrations. It also allosterically modulates nicotinic acetylcholine receptors, enhancing cholinergic neurotransmission in brain regions involved in learning and memory, which contributes to its therapeutic effect in Alzheimer’s disease.

Side Effects

Galantamine may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools occurring after dosing.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Severe bradycardia: markedly slow heart rate requiring medical attention.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Seizures: rare occurrence of convulsive episodes.

Precautions & Warnings

  • When prescribing galantamine, clinicians should consider several safety measures to minimize risk.
  • Dose titration: start with a low dose and increase gradually as tolerated.
  • Renal impairment: adjust dose in patients with reduced kidney function.
  • Hepatic impairment: monitor liver function and consider dose reduction.
  • Cardiac conduction disorders: use with caution in patients with bradyarrhythmias.
  • Concomitant anticholinergic drugs: avoid or monitor for reduced efficacy.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Galantamine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Concurrent use with other acetylcholinesterase inhibitors: risk of cholinergic excess.
  • Potent anticholinergic agents: may diminish therapeutic effect.
  • Drugs that prolong the QT interval: increased risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may raise galantamine plasma levels.
  • CYP3A4 inducers (e.g., carbamazepine, phenytoin): may lower galantamine exposure.
  • Beta‑blockers: may enhance bradycardic effects of galantamine.

Frequently Asked Questions

Memo contains galantamine, which is prescribed for the symptomatic treatment of mild to moderate Alzheimer’s disease in adults. It helps improve cognitive function, memory, and the ability to perform daily activities by enhancing cholinergic neurotransmission in the brain.

Galantamine works by reversibly inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine. This inhibition raises acetylcholine levels in synapses, supporting neuronal communication. Additionally, galantamine modulates nicotinic acetylcholine receptors, further enhancing cholinergic signaling important for learning and memory.

The dosage of Memo is individualized by the prescribing clinician. Treatment typically begins with a low dose that is gradually increased based on tolerability and clinical response. The prescriber determines the final regimen according to the patient’s condition and renal or hepatic function.

The safety of galantamine in pregnancy and lactation has not been established. It is classified as a pregnancy category with unknown risk, and use is generally avoided unless the potential benefit to the mother outweighs any possible risk to the fetus or infant.

To order Memo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Memo (galantamine) belongs to the acetylcholinesterase inhibitor class, similar to donepezil and rivastigmine. Compared with donepezil, galantamine also modulates nicotinic receptors, which may offer additional cognitive benefits for some patients. Rivastigmine is available as a transdermal patch, while galantamine is administered orally, providing a different dosing flexibility.

Memo should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the tablet container tightly closed and out of reach of children. Do not store in a refrigerator or freezer.

Memo is taken orally as a tablet. The tablet should be swallowed whole with a full glass of water, preferably with meals to reduce gastrointestinal discomfort. The exact timing and frequency are determined by the prescribing clinician based on the individual treatment plan.

Serious risks include severe bradycardia, which can cause fainting or require medical intervention, hepatotoxicity indicated by elevated liver enzymes, and rare seizures. Patients should promptly report symptoms such as unusually slow heart rate, yellowing of the skin or eyes, or convulsive episodes to their healthcare provider.

Memo is contraindicated in patients with known hypersensitivity to galantamine or any excipients, those with severe hepatic impairment, and individuals with significant cardiac conduction disorders such as sick‑sinus syndrome or advanced atrioventricular block unless a pacemaker is in place.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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