Product image of Memolan (Memantine Hydrochloride) supplied by GNH India

Memolan

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Memolan (Memantine Hydrochloride)

Memantine hydrochloride, the active ingredient in Memolan, is a NMDA receptor antagonist presented as an oral formulation for systemic use. It is indicated for the treatment of Alzheimer’s disease, particularly in patients with moderate to severe cognitive impairment.
GNH India supplies Memolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Memolan is an NMDA receptor antagonist used in the management of neurodegenerative conditions affecting cognition and behavior.

  • Alzheimer’s disease (moderate to severe): improves cognition, global functioning and daily activities.
  • Behavioral symptoms in Alzheimer’s disease: reduces agitation, aggression and psychotic features.
  • Dementia associated with Parkinson’s disease: may provide modest improvement in cognitive function.

How It Works

  • Memantine hydrochloride acts as a non‑competitive antagonist at the N‑methyl‑D‑aspartate (NMDA) receptor. By binding to the receptor‑associated ion channel with moderate affinity, it blocks excessive calcium influx caused by prolonged glutamate activation, thereby reducing excitotoxic neuronal injury while preserving normal synaptic transmission.

Side Effects

Memolan may be associated with a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Confusion
  • Fatigue
  • Hypertension

Serious or Rare Side Effects

  • Seizures
  • Cardiac arrhythmias
  • Severe hepatic injury
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Suicidal ideation or behavior
  • Psychosis or severe agitation

Precautions & Warnings

Prior to initiating Memolan, clinicians should evaluate patient‑specific factors that may influence safety and efficacy.

  • Renal impairment: adjust dose or monitor plasma levels.
  • Hepatic dysfunction: use with caution and monitor liver enzymes.
  • History of seizures: assess risk and consider alternative therapy.
  • Cardiovascular disease: monitor blood pressure and heart rhythm.
  • Pregnancy and lactation: safety not established; weigh potential benefits against risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Memolan can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Amantadine: additive CNS depression and increased dizziness.
  • Other NMDA antagonists: risk of excessive neuro‑inhibition.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may diminish cognitive benefit.
  • Cimetidine or other renal excretion inhibitors: can raise memantine plasma concentrations.
  • Diuretics: may affect electrolyte balance and blood pressure.

Frequently Asked Questions

Memolan contains memantine hydrochloride and is prescribed for the management of Alzheimer’s disease, especially in patients with moderate to severe cognitive decline. It helps improve memory, reasoning and daily functioning by protecting neurons from excitotoxic damage.

Memantine acts as a non‑competitive antagonist at NMDA receptors. By blocking excessive calcium entry caused by prolonged glutamate stimulation, it reduces neuronal excitotoxicity while allowing normal synaptic activity, which supports cognitive function in Alzheimer’s disease.

The dosage of Memolan is determined by the prescribing clinician based on the patient’s clinical condition, renal function and tolerability. The prescriber will set the appropriate strength and dosing schedule according to current medical guidelines.

Safety data for memantine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Memolan, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Memolan (memantine) belongs to the NMDA receptor antagonist class, differing from acetylcholinesterase inhibitors such as donepezil. While both improve cognition, memantine is typically used in moderate to severe stages and may have a lower incidence of gastrointestinal side effects compared with some cholinesterase inhibitors.

Memolan should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Memolan is taken orally, usually as a tablet, with or without food. The exact administration schedule is set by the prescriber, who may start with a low dose and titrate upward based on tolerability and therapeutic response.

Serious risks include seizures, severe cardiac arrhythmias, hepatic injury, and rare skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored for any new or worsening neurological or dermatological symptoms and seek immediate medical attention if they occur.

Memolan is contraindicated in patients with known hypersensitivity to memantine or any component of the formulation. Caution is advised for individuals with severe renal impairment, uncontrolled epilepsy, or significant cardiac disease, and it should be avoided in those where the risk outweighs potential benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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